Design, synthesis and evaluation of a series of novel fumagillin analogues

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 5051-5058

  Fardis, Maria ^a   Pyun, Hyung Jung ^a   Tario, James ^a   Jin, Haolun ^a   Kim, Choung U ^a   Ruckman, Judy ^b   Lin, Yun ^c   Green, Louis ^c   Hicke, Brian ^d  

^a Gilead ^*  (United States)

^b CBR International Corporation   (United States)

^c Replidyne Inc   (United States)

^d SomaLogic Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2 DIMETHYLAMINOETHYL)CARBAMIC ACID 4 (1 BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 3 (1 BENZYLOXYIMINOETHYL) 4 CHLOROMETHYL 4 HYDROXY 2 METHOXYCYCLOHEXANONE; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID 3 (1 BENZYLOXYIMINOETHYL) 4 CHLOROMETHYL 4 HYDROXY 2 METHOXYCYCLOHEXYL ESTER; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID 4 (1 BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID 4 (1,5 DIMETHYLHEXA 1,4 DIENYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID 4 CHLOROMETHYL 3 (1,5 DIMETHYLHEXA 1,4 DIENYL) 4 HYDROXY 2 METHOXYCYCLOHEXYL ESTER; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID 4 CHLOROMETHYL 4 HYDROXY 2 METHOXY 3 [2 METHYL 3 (3 METHYLBUT 2 ENYL)OXIRANYL]CYCLOHEXYL ESTER; 3 (3,4,5 TRIMETHOXYPHENYL)ACRYLIC ACID 5 METHOXY 4 [2 METHYL 3 (3 METHYLBUT 2 ENYL)OXYRANYL] 1 OXASPIRO[2.5]OCT 6 YL ESTER; 4 (1 BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCTAN 6 ONE; 4 BENZYLPIPERAZINE 1 CARBOXYLIC ACID 4 (1 BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 4 CHLOROMETHYL 4 HYDROXY 2 METHOXY 3 [2 METHYL 3 (3 METHYLBUT 2 ENYL)OXIRANYL]CYCLOHEXANONE; 4 ETHYLPIPERAZINE 1 CARBOXYLIC ACID 4 (1 BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 4 METHYLPIPERADINE 1 CARBOXYLIC ACID 4 (BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 4 METHYLPIPERAZINE 1 CARBOXYLIC ACID 4 (1 BENZYLOXYIMINOETHYL) 5 METHOXY 1 OXASPIRO[2.5]OCT 6 YL ESTER; 5 METHOXY 4 [2 METHYL 3 (3 METHYLBUT 2 ENYL)OXIRANYL] 1 OXASPIRO[2.5]OCTAN 6 ONE; 5 METHOXY 4 [2 METHYL 3 (3 METHYLBUT 2 ENYL)OXIRANYL] 1 OXASPIRO[2.5]OCTAN 6 ONE OXIME; ANGIOGENESIS INHIBITOR; FUMAGILLIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; SUBSTITUTION REACTION; UMBILICAL VEIN;

EID: 0242266514     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.08.031     Document Type: Article

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