siRNA targeting the Leader sequence of SARS-CoV inhibits virus replication

Gene Therapy

Volumn 12, Issue 9, 2005, Pages 751-761

  Li, T ^a   Zhang, Y ^a   Fu, L ^b   Yu, C ^b   Li, X ^a   Li, Y ^a   Zhang, X ^a   Rong, Z ^a   Wang, Y ^a   Ning, H ^a   Liang, R ^c   Chen, W ^b   Babiuk, L A ^c   Chang, Z ^a  

^a TSINGHUA UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Coronavirus; Gene silence; Leader sequence; RNA interference; SARS; SARS CoV; siRNA

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; RED FLUORESCENT PROTEIN; SMALL INTERFERING RNA; VIRUS SPIKE PROTEIN;

5' UNTRANSLATED REGION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SPECIFICITY; DRUG TARGETING; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; VERO CELL; VIRUS INHIBITION; VIRUS REPLICATION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENES, REPORTER; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA, VIRAL; SARS VIRUS; TRANSFECTION; VERO CELLS; VIRUS REPLICATION;

CORONAVIRUS; SARS ASSOCIATED CORONAVIRUS; SARS COV;

EID: 20844458742     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302479     Document Type: Article

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