Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate treatment

Journal of Biological Chemistry

Volumn 280, Issue 24, 2005, Pages 22721-22731

  Skacel, Nancy ^a   Menon, Lata G ^b   Mishra, Prasunkumar J ^b   Peters, Rowayda ^b   Banerjee, Debabrata ^b   Bertino, Joseph R ^b,c   Abali, Emine Ercikan ^b,c  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; ENZYMES; MATHEMATICAL MODELS; MUTAGENESIS; RNA; SENSITIVITY ANALYSIS; TOXICITY;

DIHYDROFOLATE REDUCTASE (DHFR); METHOTREXATE; OVARY CELLS; TRANSLATION;

AMINO ACIDS;

AMINO ACID; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; GLUTAMIC ACID; LEUCINE; MESSENGER RNA; METHOTREXATE; PEMETREXED; RALTITREXED; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CATALYSIS; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; ENZYME CONFORMATION; ENZYME REGULATION; FEEDBACK SYSTEM; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA TRANSLATION;

AMINO ACIDS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; CELL SURVIVAL; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CYSTEINE; DNA PRIMERS; FOLIC ACID ANTAGONISTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMIC ACID; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LEUCINE; METHOTREXATE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADP; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; SPECTROPHOTOMETRY; TETRAHYDROFOLATE DEHYDROGENASE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

CRICETULUS GRISEUS;

EID: 20744445009     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500277200     Document Type: Article

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