Hemodynamics characteristics, myocardial kinetics and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection

Journal of the American College of Cardiology

Volumn 28, Issue 5, 1996, Pages 1292-1300

  Skyba, Danny M ^a   Camarano, Gustavo ^a   Goodman, Norman C ^a   Price, Richard J ^a   Skalak, Thomas C ^a   Kaul, Sanjiv ^a,b  

^a University of Virginia ^*  (United States)

^b UNIVERSITY OF VIRGINIA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUNEX; CONTRAST MEDIUM; FS 069; UNCLASSIFIED DRUG; ALBUMINOID; FLUOROCARBON;

ANIMAL EXPERIMENT; ARTICLE; BLOOD RHEOLOGY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; DRUG EFFECT; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE SIZE; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; LUNG GAS EXCHANGE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; HEART MUSCLE; HEART VENTRICLE; METABOLISM; MICROCIRCULATION; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT;

ALBUMINS; ANIMALS; CONTRAST MEDIA; CORONARY CIRCULATION; DOGS; ECHOCARDIOGRAPHY; FLUOROCARBONS; HEART VENTRICLES; HEMODYNAMIC PROCESSES; INJECTIONS, INTRAVENOUS; MICROCIRCULATION; MODELS, CARDIOVASCULAR; MYOCARDIUM; PULMONARY GAS EXCHANGE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030274319     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(96)00328-2     Document Type: Article

References (30)

1. 1. Kaul S, Glasheen W, Ruddy TD, Pandian NG, Weyman AE, Okada RD. The importance of defining left ventricular "area at risk" in-vivo during acute myocardial infarction: an experimental evaluation utilizing myocardial contrast 2D-echocardiography. Circulation 1987;75:1249-60.
2. 2. Villanueva FS, Glasheen WP, Sklenar J, Kaul S. Assessment of risk area during coronary occlusion and infarct size after reperfusion with myocardial contrast echocardiography using left and right atrial injections of contrast. Circulation 1993;88:596-604.
3. 3. Sabia PJ, Powers ER, Jayaweera AR, Ragosta M, Kaul S. Functional significance of collateral blood flow in patients with recent acute myocardial infarction. A study using myocardial contrast echocardiography. Circulation 1992;85:2080-9.
4. 4. Sabia PJ, Powers ER, Ragosta M, Sarembock IJ, Burwell LR, Kaul S. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med 1992;372:1825-31.
5. 5. Ragosta M, Camarano G, Kaul S, Powers E, Sarembock IJ, Gimple LW. Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction: new insights using myocardial contrast echocardiography. Circulation 1994;89:2562-9.
6. 6. Villanueva FS, Glasheen WP, Sklenar J, Kaul S. Characterization of spatial patterns of flow within the reperfused myocardium using myocardial contrast echocardiography: implications in determining the extent of myocardial salvage. Circulation 1993;88:2596-606.
7. 7. Ismail S, Jayaweera AR, Goodman NC, Camarano GP, Skyba DM, Kaul S. Detection of coronary artery stenoses and quantification of blood flow mismatch during coronary hyperemia with myocardial contrast echocardiography. Circulation 1995;91:821-30.
8. 8. Villanueva FS, Spotnitz WD, Jayaweera AR, Gimple LW, Dent J, Kaul S. On-line intraoperative quantitation of regional myocardial perfusion during coronary artery bypass graft operations with myocardial contrast two-dimensional echocardiography. J Thorac Cardiovasc Surg 1992;104:1524-31.
9. 9. Villanueva FS, Spotnitz WD, Glasheen WP, Kaul S. New insights into the physiology of retrograde cardioplegia delivery comparison with anterograde delivery. Am J Physiol 1995;268:H1555-66.
10. 10. Porter T, Xie F, Kilzer K. Intravenous perfluoropropane-exposed sonicated dextrose albumin produces myocardial contrast which correlates with coronary blood flow. J Am Soc Echocardiogr 1995;8:710-8.
11. 11. Albers VM. Underwater Acoustic Handbook. Hershey (PA): Pennsylvania State University Press, 1960.
12. 12. Firschke C, Lindner JR, Wei K, Goodman NC, Kaul S. Detection of coronary stenoses using venous injection of FS-069 with intermittent harmonic imaging [abstract]. J Am Soc Echocardiogr 1996;9:362.
13. 99mTc-sestamibi single photon emission computed tomography [abstract]. Circulation. In Press.
14. 14. Gray SD. Rat spinotrapezius muscle preparation for microscopic observation of the terminal vascular bed. Microvasc Res 1973;5:395-400.
15. 15. Jayaweera AR, Matthew TL, Sklenar J, Spotnitz WD, Watson DD, Kaul S. Method for the quantitation of myocardial perfusion during myocardial contrast two-dimensional echocardiography. J Am Soc Echocardiogr 1990: 3:91-8.
16. 16. Heyman MA, Payne BD, Hoffman JI, Rudolf AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 1977;20:52-79.
17. 17. Keller MW. Segal SS, Kaul S, Duling B. The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography. Circ Res 1989;65:458-67.
18. 18. Jayaweera AR, Edwards N, Glasheen WP, Villanueva FS, Abbott RD, Kaul S. In-vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: comparison with radiolabeled red blood cells. Circ Res 1994;74:1157-65.
19. 19. Skalak TC, Schmid-Schonbein GW. The microvasculature in skeletal muscle iv. A model of the capillary network. Microvasc Res 1986;32:333-47.
20. 20. Mazzoni MC, Skalak TC, Schmid-Schonbein GW. Effects of skeletal muscle fiber deformation on lymphatic volume. Am J Physiol 1990;259:H1860-8.
21. 21. Wibble JH, Wojdyla JK, Bales GL, McMullen WN, Geiser EA, Buss DD. Inhaled gases affect the ultrasound contrast produced by Albunex in anesthetized dogs. J Am Soc Echocardiogr 1996;9:442-51.
22. 22. Vuille C, Nidorf M, Morrissey RL, Newell JB, Weyman AE, Picard MH. Effect of static pressure on the disappearance rate of specific echocardiographic contrast agents. J Am Soc Echocardiogr 1994;7:347-54.
23. 23. Galanti G, Jayaweera AR, Villanueva FS, Glasheen WP, Ismail S, Kaul S. Transpulmonary transit of microbubbles during contrast echocardiography: implications for estimating cardiac output and pulmonary blood volume. J Am Soc Echocardiogr 1993;6272-8,
24. 24. Lindner JR, Kaul S. Insights into the assessment of myocardial perfusion offered by the different currently used cardiac imaging modalities. J Nucl Cardiol 1995;2:446-60.
25. 25. Porter TR, Xie F. Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles. Demonstration of potential mechanisms. Circulation 1995;92: 2391-5.
26. 26. Wei K, Skyba DM, Firschke C, Lindner JR, Jayaweera AR, Kaul S. Why are bubbles destroyed by ultrasound? [abstract] Circulation. In Press.
27. 27. Ismail S, Jayaweera AR, Camarano G, Gimple LW, Powers ER, Kaul S. Relation between Air-filled Albumin Microbubble and Red Blood Cell Rheology in the Human Myocardium: Influence of Echocardiographic Systems and Chest Wall Attenuation. Circulation 1996;94:445-51.
28. 28. Bach DS, Muller DWM, Cheirif J, Armstrong W. Regional heterogeneity on myocardial contrast echocardiography without severe obstructive coronary artery disease. Am J Cardiol 1995;75:982-6.
29. 29. Keller MW, Glasheen WP, Kaul S. Albunex: a safe and effective commercially produced agent for myocardial contrast echocardiography. J Am Soc Echocardiogr 1989;2:48-52.
30. 30. ten Gate FJ, Widimsky P, Cornel JH, Waldstein DJ, Serruys PW, Waaler A. Intracoronary Albunex. Its effect on left ventricular hemodynamics, function, and coronary sinus flow in humans. Circulation 1993;88:2123-7.