Sex differences in N-acetylaspartate correlates of general intelligence: An 1H-MRS study of normal human brain

NeuroImage

Volumn 26, Issue 3, 2005, Pages 965-972

  Jung, Rex E ^a,c   Haier, Richard J ^d   Yeo, Ronald A ^b   Rowland, Laura M ^e   Petropoulos, Helen ^f   Levine, Andrea S ^c   Sibbitt, Wilmer L ^a   Brooks, William M ^g  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c MIND RESEARCH NETWORK   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Cognitive; Intelligence; N acetylaspartate; Sex differences; Spectroscopy; White matter

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ARTICLE; ASSOCIATION CORTEX; BRAIN REGION; CHEMICAL ANALYSIS; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; INTELLIGENCE; INTELLIGENCE TEST; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERFORMANCE; PREDICTION; PRIORITY JOURNAL; SEX DIFFERENCE; WHITE MATTER;

ADOLESCENT; ADULT; ASPARTIC ACID; BRAIN CHEMISTRY; COGNITION; FEMALE; HUMANS; INTELLIGENCE; LINEAR MODELS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NERVE FIBERS; REFERENCE VALUES; SEX CHARACTERISTICS; WECHSLER SCALES;

EID: 20444483787     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2005.02.039     Document Type: Article

References (76)

1. B. Anderson Brain imaging and g The Scientific Study of General Intelligence 2003 Pergamon Oxford 29 39 H. Nyborg
2. N.C. Andreasen, M. Flaum, V. Swayze II, D.S. O'Leary, R. Alliger, G. Cohen, J. Ehrhardt, and W.T. Yuh Intelligence and brain structure in normal individuals Am. J. Psychiatry 150 1 1993 130 134
3. P.B. Barker N-acetyl aspartate-a neuronal marker? Ann. Neurol. 49 4 2001 423 424
4. P.B. Barker, K. Szopinski, and A. Horska Metabolic heterogeneity at the level of the anterior and posterior commissures Magn. Reson. Med. 43 3 2000 348 354
5. G. Bartzokis, J.L. Cummings, D. Sultzer, V.W. Henderson, K.H. Nuechterlein, and J. Mintz White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study Arch. Neurol. 60 3 2003 393 398
6. M.H. Baslow Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation J. Mol. Neurosci. 21 3 2003 185 190
7. M.H. Baslow N-acetylaspartate in the vertebrate brain: metabolism and function Neurochem. Res. 28 6 2003 941 953
8. G.D. Batty, and I.J. Deary Early life intelligence and adult health-associations, plausible mechanisms, and public health importance are emerging Br. Med. J. 329 7466 2004 585 586
9. K.K. Bhakoo, and D. Pearce In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo J. Neurochem. 74 1 2000 254 262
10. P. Broca Remarques sur le siege de la faculte du langage articule Bull. Soc. Anthrop. 1861 6
11. W.M. Brooks, S.D. Friedman, and C. Gasparovic Magnetic resonance spectroscopy in traumatic brain injury J. Head Trauma Rehabil. 16 2 2001 149 164
12. N. De Stefano, P.M. Matthews, and D.L. Arnold Reversible decreases in N-acetylaspartate after acute brain injury Magn. Reson. Med. 34 5 1995 721 727
13. D.K. Detterman General intelligence and the definition of phenotypes Novartis Found. Symp. 233 2000 136 144 (discussion 144-8)
14. J. Duncan, R.J. Seitz, J. Kolodny, D. Bor, H. Herzog, A. Ahmed, F.N. Newell, and H. Emslie A neural basis for general intelligence Science 289 5478 2000 457 460
15. V. Egan, A. Chiswick, C. Santosh, K. Naidu, J.E. Rimmington, and J.J.K. Best Size isnt everything-a study of brain volume, intelligence and auditory-evoked potentials Pers. Individ. Differ. 17 3 1994 357 367
16. T. Ernst, and L. Chang Elimination of artifacts in short echo time H MR spectroscopy of the frontal lobe Magn. Reson. Med. 36 3 1996 462 468
17. K.J. Ferguson, A.M. MacLullich, I. Marshall, I.J. Deary, J.M. Starr, J.R. Seckl, and J.M. Wardlaw Magnetic resonance spectroscopy and cognitive function in healthy elderly men Brain 125 Pt. 12 2002 2743 2749
18. P.A. Filipek, C. Richelme, D.N. Kennedy, and V.S. Caviness Jr. The young adult human brain: an MRI-based morphometric analysis Cereb. Cortex 4 4 1994 344 360
19. L.A. Flashman, N.C. Andreasen, M. Flaum, and V.W. Swayze Intelligence and regional brain volumes in normal controls Intelligence 25 3 1997 149 160
20. M.J.P. Flourens Recherches experimentales sur les proprietes et les fonctions du systeme nerveux dans les animaux vertibres 1824 Crevot Paris
21. D.G. Gadian, E.B. Isaacs, J.H. Cross, A. Connelly, G.D. Jackson, M.D. King, B.G. Neville, and F. Vargha-Khadem Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy Neurology 46 4 1996 974 977
22. F.J. Gall Sur les fonctions du cerveau et sur celles de chacune de ses parties 1825 Bailliere Paris
23. F. Galton Hereditary genius 1869 Macmillan London
24. G. Gignac, P.A. Vernon, and J.C. Wickett Factors influencing the relationship between brain size and intelligence. The scientific study of general intelligence H. Nyborg. Oxford 2003 93 106
25. J.M. Goldstein, L.J. Seidman, N.J. Horton, N. Makris, D.N. Kennedy, V.S. Caviness, S.V. Faraone, and M.T. Tsuang Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging Cereb. Cortex 11 6 2001 490 497
26. L.S. Gottfredson Why g matters: the complexity of everyday life Intelligence 24 1 1997 79 132
27. Grachev, I.D., Kumar, R., Ramachandran, T.S., Szeverenyi, N.M., 2001. Cognitive interference is associated with neuronal marker N-acetyl aspartate in the anterior cingulate cortex: an in vivo (1)H-MRS study of the Stroop Color-Word task. Mol. Psychiatry 6 (5): 496, 529-539.
28. J.R. Gray, C.F. Chabris, and T.S. Braver Neural mechanisms of general fluid intelligence Nat. Neurosci. 6 3 2003 316 322
29. R.C. Gur, B.I. Turetsky, M. Matsui, M. Yan, W. Bilker, P. Hughett, and R.E. Gur Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance J. Neurosci. 19 10 1999 4065 4072
30. R.J. Haier, B.V. Siegel, K.H. Nuechterlein, E. Hazlett, J.C. Wu, J. Paek, H.L. Browning, and M.S. Buchsbaum Cortical glucose metabolicrate correlates of abstract reasoning and attention studied with positron emission tomography Intelligence 12 2 1988 199 217
31. R.J. Haier, B.V. Siegel Jr., A. MacLachlan, E. Soderling, S. Lottenberg, and M.S. Buchsbaum Regional glucose metabolic changes after learning a complex visuospatial/motor task: a positron emission tomographic study Brain Res. 570 1-2 1992 134 143
32. R.J. Haier, D. Chueh, P. Touchette, I. Lott, M.S. Buchsbaum, D. Macmillan, C. Sandman, L. Lacasse, and E. Sosa Brain size and cerebral glucose metabolic-rate in nonspecific mental-retardation and down-syndrome Intelligence 20 2 1995 191 210
33. R.J. Haier, N.S. White, and M.T. Alkire Individual differences in general intelligence correlate with brain function during nonreasoning tasks Intelligence 31 1999 429 441
34. R. Haier, R.E. Jung, R. Yeo, K. Head, and M.T. Alkire Structural brain variation and general intelligence NeuroImage 23 1 2004 425 433
35. R.J. Haier, R.E. Jung, R.A Yeo, K. Head, and M.T. Alkire The neuroanatomy of general intelligence: sex matters NeuroImage 25 1 2005 320 327
36. I. Harvey, R. Persaud, M.A. Ron, G. Baker, and R.M. Murray Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls Psychol. Med. 24 1994 689 699
37. T. Hashimoto, M. Tayama, M. Miyazaki, Y. Yoneda, T. Yoshimoto, M. Harada, H. Miyoshi, M. Tanouchi, and Y. Kuroda Reduced N-acetylaspartate in the brain observed on in vivo proton magnetic resonance spectroscopy in patients with mental retardation Pediatr. Neurol. 13 3 1995 205 208
38. H.P. Hetherington, G.F. Mason, J.W. Pan, S.L. Ponder, J.T. Vaughan, D.B. Twieg, and G.M. Pohost Evaluation of cerebral gray and white matter metabolite differences by spectroscopic imaging at 4.1 T Magn. Reson. Med. 32 5 1994 565 571
39. J.H. Jackson Selected writings of John Hughlings Jackson 1932 Hodder and Stoughton London
40. R.E. Jung, W.M. Brooks, R.A. Yeo, S.J. Chiulli, D.C. Weers, and W.L. Sibbitt Jr. Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain Proc. R. Soc. Lond., B Biol. Sci. 266 1426 1999 1375 1379
41. R.E. Jung, R.A. Yeo, S.J. Chiulli, W.L. Sibbitt Jr., D.C. Weers, B.L. Hart, and W.M. Brooks Biochemical markers of cognition: a proton MR spectroscopy study of normal human brain NeuroReport 10 16 1999 3327 3331
42. R.E. Jung, R.A. Yeo, S.J. Chiulli, W.L. Sibbitt Jr., and W.M. Brooks Myths of neuropsychology: intelligence, neurometabolism, and cognitive ability Clin. Neuropsychol. 14 4 2000 535 545
43. K. Kleist Gehirnpathologie 1934 Leipzig Barth
44. K.S. Lashley Brain mechanisms and intelligence 1929 University of Chicago Press Chicago
45. E. Martin, A. Capone, J. Schneider, J. Hennig, and T. Thiel Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy? Ann. Neurol. 49 4 2001 518 521
46. A. Moreno, B.D. Ross, and S. Bluml Direct determination of the N-acetyl-l-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion J. Neurochem. 77 1 2001 347 350
47. S. Narayanan, N. De Stefano, G.S. Francis, R. Arnaoutelis, Z. Caramanos, D.L. Collins, D. Pelletier, B.G.W. Arnason, J.P. Antel, and D.L. Arnold Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b J. Neurol. 248 11 2001 979 986
48. U. Neisser, G. Boodoo, T.J. Bouchard, A.W. Boykin, N. Brody, S.J. Ceci, D.F. Halpern, J.C. Loehlin, R. Perloff, R.J. Sternberg, and S. Urbina Intelligence: knowns and unknowns Am. Psychol. 51 2 1996 77 101
49. A.C. Neubauer, A. Fink, and D.G. Schrausser Intelligence and neural efficiency: the influence of task content and sex on the brain-IQ relationship Intelligence 30 6 2002 515 536
50. S.M. Noworolski, S.J. Nelson, R.G. Henry, M.R. Day, L.L. Wald, J. Star-Lack, and D.B. Vigneron High spatial resolution 1H-MRSI and segmented MRI of cortical gray matter and subcortical white matter in three regions of the human brain Magn. Reson. Med. 41 1 1999 21 29
51. Pavlov, I.P.,1949. Complete collected works. Moscow, Izd. AU SSSR.
52. B.F. Pennington, P.A. Filipek, D. Lefly, N. Chhabildas, D.N. Kennedy, J.H. Simon, C.M. Filley, A. Galaburda, and J.C. DeFries A twin MRI study of size variations in human brain J. Cogn. Neurosci. 12 1 2000 223 232
53. H. Petropoulos, W.L.Jr. Sibbitt, and W.M. Brooks Automated T2 quantitation in neuropsychiatric lupus erythematosus: a marker of active disease J. Magn. Reson. Imaging 9 1 1999 39 43
54. B. Pfleiderer, P. Ohrmann, T. Suslow, M. Wolgast, A.L. Gerlach, W. Heindel, and N. Michael N-acetylaspartate levels of left frontal cortex are associated with verbal intelligence in women but not in men: a proton magnetic resonance spectroscopy study Neuroscience 123 4 2004 1053 1058
55. V. Prabhakaran Neural substrates of fluid reasoning: an fMRI study of neocortical activation during performance of the Raven's progressive matrices test Cogn. Psychol. 33 1 1997 43 63
56. S.W. Provencher Estimation of metabolite concentrations from localized in vivo proton NMR spectra Magn. Reson. Med. 30 6 1993 672 679
57. C. Rae, A. Karmiloff-Smith, M.A. Lee, R.M. Dixon, J. Grant, A.M. Blamire, C.H. Thompson, P. Styles, and G.K. Radda Brain biochemistry in Williams syndrome: evidence for a role of the cerebellum in cognition? Neurology 51 1 1998 33 40
58. L.T. Rael, G.W. Thomas, R. Bar-Or, M.L. Craun, and D. Bar-Or An anti-inflammatory role for N-acetyl aspartate in stimulated human astroglial cells Biochem. Biophys. Res. Commun. 319 2004 847 853
59. N. Raz, I.J. Torres, W.D. Spencer, D. Millman, J.C. Baertschi, and G. Sarpel Neuroanatomical correlates of age-sensitive and age-invariant cognitive-abilities-an in-vivo MRI investigation Intelligence 17 3 1993 407 422
60. A.L. Reiss, M.T. Abrams, H.S. Singer, J.L. Ross, and M.B. Denckla Brain development, gender and IQ in children-a volumetric imaging study Brain 119 1996 1763 1774
61. A.J. Ross, and P.S. Sachdev Magnetic resonance spectroscopy in cognitive research Brain Res. Brain Res. Rev. 44 2-3 2004 83 102
62. P.T. Schoenemann, T.F. Budinger, V.M. Sarich, and W.S.Y. Wang Brain size does not predict general cognitive ability within families Proc. Natl. Acad. Sci. U. S. A. 97 9 2000 4932 4937
63. B.J. Soher, R.E. Hurd, N. Sailasuta, and P.B. Barker Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference Magn. Reson. Med. 36 3 1996 335 339
64. C. Spearman General intelligence, objectively determined and measured Am. J. Psychol. 15 1904 201 293
65. The Psychological Corporation WAIS-III/WMS-III technical manual 1997 Author San Antonio, Texas
66. E.L. Thorndike Intelligence and its measurement: a symposium J. Educ. Psychol. 12 1921 124 127
67. M.J. Tramo, W.C. Loftus, T.A. Stukel, R.L. Green, J.B. Weaver, and M.S. Gazzaniga Brain size, head size, and intelligence quotient in monozygotic twins Neurology 50 5 1998 1246 1252
68. J. Urenjak, S.R. Williams, D.G. Gadian, and M. Noble Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types J. Neurosci. 13 3 1993 981 989
69. M.J. Valenzuela, P.S. Sachdev, W. Wen, R. Shnier, H. Brodaty, and D. Gillies Dual voxel proton magnetic resonance spectroscopy in the healthy elderly: subcortical-frontal axonal N-acetylaspartate levels are correlated with fluid cognitive abilities independent of structural brain changes NeuroImage 12 6 2000 747 756
70. L. Van Valen Brain size and intelligence in man Am. J. Phys. Anthropol. 40 1974 417 423
71. N.P. Walker, P.M. McConville, D. Hunter, I.J. Deary, and L.J. Whalley Childhood mental ability and lifetime psychiatric contact-a 66-year follow-up study of the 1932 Scottish mental ability survey Intelligence 30 3 2002 233 245
72. D. Wechsler Wechsler adult intelligence scale 3rd ed. 1997 The Psychological Corporation San Antonio, Texas
73. J.C. Wickett, P.A. Vernon, and D.H. Lee In-vivo brain size, head perimeter, and intelligence in a sample of healthy adult females Pers. Indiv. Differ. 16 6 1994 831 838
74. J.C. Wickett, P.A. Vernon, and D.H. Lee Relationships between factors of intelligence and brain volume Pers. Indiv. Differ. 29 6 2000 1095 1122
75. D. Wiedermann, N. Schuff, G.B. Matson, B.J. Soher, A.T. Du, A.A. Maudsley, and M.W. Weiner Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability Magn. Reson. Imaging 19 8 2001 1073 1080
76. L. Willerman, R. Schultz, J.N. Rutledge, and E.D. Bigler In vivo brain size and intelligence Intelligence 15 2 1991 223 228