Cardiovascular effects of trans-dehydrocrotonin, a diterpene from Croton cajucara in rats

Vascular Pharmacology

Volumn 43, Issue 1, 2005, Pages 11-18

  Silva, Regilane M ^a   Oliveira, Francisco A ^a   Cunha, Karina M A ^a   Maia, Juliana L ^a   Maciel, Maria Aparecida M ^b   Pinto, Angelo C ^c   Nascimento, Nilberto R F ^d   Santos, Flavia A ^a   Rao, Vietla S N ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d STATE UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Croton cajucara; Diterpene; Hypotensive action; Left atrial contractile force; Rat; Spontaneously beating right atria; t DCTN; Vasorelaxation

Indexed keywords

ATROPINE; BETA ADRENERGIC RECEPTOR; DEHYDROCROTONIN; DITERPENE; HEXAMETHONIUM; MUSCARINIC RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; PROPRANOLOL; UNCLASSIFIED DRUG; URETHAN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; CROTON; CROTON CAJUCARA; DOSE RESPONSE; DRUG STRUCTURE; ENDOTHELIUM; GANGLION BLOCK; HEART ATRIUM CONTRACTION; HEART BEAT; HEART HEMODYNAMICS; HEART LEFT ATRIUM; HEART MUSCLE CONTRACTILE FORCE; HEART RATE; INOTROPISM; ISOLATED ARTERY; MALE; MEAN ARTERIAL PRESSURE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; RAT; SINUS NODE; VASCULAR RING; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; ATROPINE; BLOOD PRESSURE; CROTON; DITERPENES, CLERODANE; ENZYME INHIBITORS; HEART ATRIA; HEART RATE; HEMODYNAMIC PROCESSES; HEXAMETHONIUM COMPOUNDS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHENYLEPHRINE; RATS; RATS, WISTAR; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 20444447573     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2005.02.015     Document Type: Article

References (27)

1. A.R. Âgner, M.A.M. Maciel, A.C. Pinto, G.R.S. Pamplona, and I.M.S. Cólus Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara Teratog. Carcinog. Mutagen. 19 1999 377 384
2. Berg, M.E.V., 1982. Plantas Medicinais na Amazônia: contribuição ao seu estudo sistemático, Belém, CNPq/PTU.
3. E.J.B. Bighetti, A.R.M. Souza-Brito, E.C. de Faria, and H.C.F. Oliveira Chronic treatment with bark infusion from Croton cajucara lowers plasma triglyceride levels in genetic hyperlipidemic mice Can. J. Physiol. Pharm. 82 2004 387 392
4. A.R. Brito, J.A. Rodríguez, C.A. Hiruma-Lima, M. Haun, and D.S. Nunes Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara Planta. Med. 64 1998 126 129
5. J.C. Carvalho, M.F. Silva, M.A. Maciel, A.C. Pinto, D.S. Nunes, R.M. Lima, J.K. Bastos, and S.J. Sarti Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1 Planta Med. 62 1996 402 404
6. P. Da Silva Melo, N. Duran, and M. Haun Cytotoxicity of derivatives from dehydrocrotonin on V79 cells and Escherichia coli Toxicology 159 2001 135 141
7. M. Di Napoli Benefits of statins in cerebrovascular disease Curr. Opin. Investig. Drugs 5 2004 295 305
8. L.C. Di Stasi, E.M.C. Santos, C. Moreira dos Santos, and C.A. Hiruma Plantas Medicinais da Amazônia, Editora UNESP, SP 1989 127 128
9. S.A. Doggrell The effects of bromoacetylalprenololmenthane (BAAM), an irreversible β-adrenoceptor antagonist, on the rat isolated left atria and portal vein J. Auton. Pharm. 10 1990 333 344
10. R.A.F. Farias, V.S.N. Rao, G.S.B. Viana, E.R. Silveira, M.A.M. Maciel, and A.C. Pinto Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara Planta Med. 66 1997 558 560
11. N.F. Grynberg, A. Echevarria, J.E. Lima, S.G.S.R. Pamplona, A.C. Pinto, and M.A.M. Maciel Anti-tumor activity of two 19-nor-clerodane diterpenes: trans-dehydrocrotonin and trans-crotonin from Croton cajucara Planta Med. 65 1999 687 689
12. M.F. Guerrero, P. Puebla, R. Carrón, M.L. Martín, and L. San Roman J. Ethnopharmacol. 94 2004 185 189
13. C.A. Hiruma-Lima, R.C. Spadari-Bratfisch, D.M. Grassi-Kassisse, and A.R. Brito Antiulcerogenic mechanisms of dehydrocrotonin, a diterpene lactone obtained from Croton cajucara Planta Med. 65 1999 325 330
14. Y. Ichihara, K. Takeya, Y. Hitotsuyanagi, H. Morita, S. Okuyama, M. Suganuma, H. Fujiki, M. Motidome, and H. Itokawa Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara Planta. Med. 58 1992 549 551
15. B.J. Janssen, P.J. Leenders, and J.F. Smits Short-term and long-term blood pressure and heart rate variability in the mouse Am. J. Physiol., Regul. Integr. Comp. Physiol. 278 2000 215 225
16. A.M. Luna Costa, J.C.R. Silva, A.R. Campos, V.S.N. Rao, M.A.M. Maciel, and A.C. Pinto Antioestrogenic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara Benth.in rats Phytother. Res. 13 1999 689 691
17. M.A.M. Maciel, A.C. Pinto, S.N. Brabo, and M.N. Silva Terpenoids from Croton cajucara Phytochemistry 49 1998 823 828
18. J.E.C. Martins Plantas Medicinais de Uso na Amazônia 1989 Centro de Estudos Jurídicos do Pará Belém, Brasil 92
19. G. Pogatsa What kind of cardiovascular alterations could be influenced positively by oral antidiabetic agents? Diabetes Res. Clin. Pract. 31 1996 S27 S31 (Suppl.)
20. J. Rodríguez, and M. Haun Cytotoxicity of trans-dehydrocrotonin from Croton cajucara on V79 cells and rat hepatocytes Planta Med. 65 1999 522 526
21. L.A. Salaco, V. Williams, and J.H. Witting Investigations to characterize a new antiarrhythmic drug, ORG 6001 including a simple test for calcium antagonism Br. J. Pharmacol. 57 1976 251 262
22. R.M. Silva, F.A. Santos, M.A.M. Maciel, A.C. Pinto, and V.S. Rao Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemis induced by Triton WR 1339 (tyloxapol) in mice Planta Med. 67 2001 763 765
23. R.M. Silva, F.A. Santos, V.S. Rao, M.A.M. Maciel, and A.C. Pinto The lipid-lowering effect of trans-dehydrocrotonin from Croton cajucara Benth in mice fed on high-fat diet J. Pharm. Pharmacol. 53 2001 535 539
24. R.M. Silva, F.A. Santos, V.S. Rao, M.A.M. Maciel, and A.C. Pinto Blood glucose and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from croton cajucara Benth in rats Diabetes Obes. Metab. 3 2001 452 456
25. C.R. Tirapelli, S.R. Ambrosio, F.B. da Costa, and A.M. de Oliveira Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on rat aorta Pharmacology 70 2004 31 38
26. C.R. Tirapelli, S.R. Ambrosio, F.B. da Costa, S.T. Coutinho, and A.M. de Oliveira Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta Eur. J. Pharmacol. 492 2004 233 241
27. A. Virdis, and E.L. Schiffrin Vascular inflammation: a role in vascular disease in hypertension? Curr. Opin. Nephrol. Hypertens. 12 2003 181 187