Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on rat aorta

Pharmacology

Volumn 70, Issue 1, 2004, Pages 31-38

  Tirapelli, Carlos R ^a   Ambrosio, Sergio R ^a   Da Costa, Fernando B ^b   De Oliveira, Ana M ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Faculdade Cie Farmaceuticas R   (Brazil)

Author keywords

Calcium influx; ent pimara 8(14),15 dien 19 oic acid; Relaxation, nifedipine induced; Relaxation, pimaradienoic acid induced; Thoracic aorta, rat

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ARACHIDONIC ACID; CAFFEINE; CALCIUM CHLORIDE; CALCIUM ION; DITERPENE; GUANYLATE CYCLASE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; PIMARADIENOIC ACID; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; ENZYME ACTIVATION; MALE; MEDICINAL PLANT; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VIGUIERA ARENARIA;

ANIMALS; AORTA, THORACIC; ASTERACEAE; BRAZIL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ETHANOL; INDOMETHACIN; MALE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NIFEDIPINE; OXADIAZOLES; PHENYLEPHRINE; PLANT EXTRACTS; PLANT ROOTS; QUINOXALINES; RATS; RATS, WISTAR; TETRAETHYLAMMONIUM; VASOCONSTRICTION; VASODILATION;

EID: 0345059936     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074240     Document Type: Article

References (19)

1. Cheung HT, Fu SL, Smal MA: Inhibition of platelet aggregation by diterpenes acids from Pinus massoniana resin. Arzneimittelforschung 1994;44:17-25.
2. Ulubelen A, Topcu G, Johansson CB: Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity. J Nat Prod 1997;60:1275-1280.
3. Suh YG, Kim YH, Park MH, Choi YH, Lee HK, Moon JY, Min KH, Shin DY, Jung JK, Park OH, Jeon RO, Park HS, Kang SA: Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship. Bioorg Med Chem Lett 2001;11:559-562.
4. Ohashi K, Bohgaki T, Matsubara T, Shibuya H: Indonesian medicinal plants. XXIII. Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae). Chem Pharm Bull 2000;48:433-435.
5. Ambrosio SR, Tirapelli CR, Bonaventura D, De Oliveira AM, Da Costa FB: Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction. Fitoterapia 2002; 73:484-489.
6. Shibata S, Mihashi S, Tanaka O: The occurrence of (-)-pimarane-type diterpene in Aralia cordata Thumb. Tetrahedron Lett 1967;51: 5241-5243.
7. Matsuo A, Uto S, Nakayama M, Hayashi S: (-)-Thermarol, a new ent-pimarane-class diterpene diol from Jungermania thermarum (liverwort). Tetrahedron Lett 1976;28:2451-2454.
8. Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-376.
9. David FL, Montezano ACI, Rebouças NA, Nigro D, Fortes ZB, Carvalho MHC, Tostes RCA: Gender differences in vascular expression of endothelin and ETA/ETB receptors, but not in calcium-handling mechanisms, in deoxycorticosterone acetate-salt hypertension. Braz J Med Biol Res 2002;35:1061-1068.
10. 1-adrenoceptors: Role of voltage-gated calcium channels and intracellular calcium stores. Urol Res 2000;28:122-127.
11. 2+ store in rabbit aorta. J Physiol 1984;357:327-339.
12. Hudgins A, Weiss G: Effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium. J Pharm Exp Ther 1968;159:91-97.
13. 2+ channels in rat aortic smooth muscle. Br J Anesth 1998;81:578-583.
14. Gibson A, Pollock D: The effects of drugs on the sensitivity of the rat anococcygeus muscle to agonists. Br J Pharmacol 1973;49:506-513.
15. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-142.
16. Robertson BE, Schubert R, Hescheler J, Nelson MT: cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol 1993;265: C299-C303.
17. Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B: Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 1995;48:184-188.
18. Hamilton TC, Weston AH: Cromakalim, nicorandil and pinacidil: Novel drugs which open potassium channels in smooth muscle. Gen Pharmacol 1989;20:1-9.
19. Nelson MT, Quayle JM: Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995;268: C799-C822.