Chronic treatment with bark infusion from Croton cajucara lowers plasma triglyceride levels in genetic hyperlipidemic mice

Canadian Journal of Physiology and Pharmacology

Volumn 82, Issue 6, 2004, Pages 387-392

  Bighetti, Eliete J B ^a   Souza Brito, Alba R M ^a   De Faria, Eliana C ^a   Oliveira, Helena C F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cholesterol; Croton cajucara; Dehydrocrotonin; Hyperlipidemia; Transgenic mice

Indexed keywords

ANTILIPEMIC AGENT; APOLIPOPROTEIN C3; CHOLESTEROL ESTER TRANSFER PROTEIN; CROTON EXTRACT; DEHYDROCROTONIN; ESSENTIAL OIL; PLACEBO; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BARK; CONTROLLED STUDY; CROTON; CROTON CAJUCARA; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; KIDNEY FUNCTION; KNOCKOUT MOUSE; LIVER FUNCTION; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY; TRANSGENIC MOUSE;

ANIMALS; CROTON; HYPERLIPIDEMIAS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PLANT BARK; PLANT EXTRACTS; RECEPTORS, LDL; TRIGLYCERIDES;

EID: 4544273401     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y04-040     Document Type: Article

References (33)

1. Aalto-Setala, K., Fisher, E.A., Chen, X., Chajek-Shaul, T., Hayek, T., Zechner, R., Walsh, A., Ramakrishnan, R., Ginsberg, H.N., and Breslow, J.L.1992. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apoE on the particles. J. Clin. Invest. 90: 1889-1900.
2. Aalto-Setala, K., Weintock, P.H., Bisgaier, C.L., Wu, L., Smith, J.D., and Breslow, J.L. 1996. Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice. J. Lipid Res. 37: 1802-1811.
3. Asset, G., Baugé, E., Wolff, R., Fruchart, J.C., and Dallongeville, J. 1999. Pinus pinaster oil affects lipoprotein metabolism in apolipoprotein E-deficient mice. J. Nutr. 129: 1972-1978.
4. Berti, J.A., Amaral. M.E.C., Boschero, A.C., Nunes, V.S., Harada, L.M., Castilho, L.N., and Oliveira, H.C.F. 2001. Thyroid hormone increases plasma cholesteryl ester transfer protein activity and plasma HDL removal rate in transgenic mice. Metabolism, 50: 530-536.
5. Braun, J.E.A., and Severson, D.L. 1992. Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem. J. 287: 337-347.
6. Breslow, J.L. 1996. Mouse models of atherosclerosis. Science, 272: 685-688.
7. Brown, W.V., and Baginsky, M.L. 1972. Inhibition of lipoprotein lipase by an apoprotein of human very low density liporotein. Biochem. Biophys. Res. Commun. 46: 375-382.
8. Craig, W.J. 1999. Health promoting properties of common herbs. Am. J. Clin. Nutr. 70: 491-499.
9. Faergeman, O. 2000. Hypertriglyceridemia and the fibrate trials. Curr. Opin. Lipidol. 11: 609-614.
10. Farias, R.A.F., Neto, M.F.O., Viana, G.S.B., and Rao, V.S.N. 1996. Effects of Croton cajucara extract on serum lipids of rats fed a high fat diet. Phytother. Res. 10: 697-699.
11. Friedwald, W.T., Levi, R.I., and Fredrickson, D.S. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502.
12. Goldstein, J.L., and Brown, M.S. 1977. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem. 46: 897-930.
13. Goldstein, J.L., and Brown, M.S. 2001. The cholesterol quartet. Science, 292: 310-317.
14. Gordon, D.J., and Rifking, B.M. 1989. High-density lipoprotein. The clinical implications of recent studies. N. Engl. J. Med. 321: 1311-1316.
15. Hiruma-Lima, C.A., Gracioso, J.S., Bighetti, E.J.B., Grassi-Kassisse, D.M., Nunes, D.S., and Souza-Brito, A.R.M. 2002. Effects of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucos. Phytomedicine, 9: 523-529.
16. Ishibashi, S., Brown, M.S., Goldstein, J.L., Gerard, R.D., Hammer, R.E., and Herz, J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92: 883-893.
17. Jiang, X.C., Agellon, L.B., Walsh, A., Breslow, J.L., and Tall, A.R. 1992. Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J. Clin. Invest. 90: 1290-1295.
18. Maciel, M.A.M., Pinto, A.C., Brabo, S.N., and Silva, M.N. 1998. Terpenoids from Croton cajucara. Phytochemistry, 49: 823-828.
19. Maciel, M.A.M., Pinto, A.C., Arruda, A.C., Pamplona, S.G., Vanderlinde, F.A., Lapa, A.J. Echevarria, A., Grynberg, N.F., Colus, I.M., Farias, R.A., Luna Costa, A.M., Rao, and V.S. 2000. Ethopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara. J. Ethnopharmacol. 70: 41-55.
20. Malloy, M.J., and Kane, J.P. 2001. A risk factor for atherosclerosis: triglyceride-rich lipoproteins. Adv. Intern. Med. 47: 111-136.
21. Masucci-Magoulas, L., Goldberg, I.J., Bisgaier, C.L., Serajuddin, H., Francone, O.L., Breslow, J.L., and Tall, A.R. 1997. A mouse model with features of familial combined hyperlipidemia. Science, 275: 391-394.
22. Miller, M. 2000. Current perspectives on the management of hypertriglyceridemia. Am. Heart J. 140: 232-240.
23. Nunes, V.S., Quintão, E.C.R., Cazita, P.M., Harada, L.M., de Faria, E.C., and Oliveira, H.C.F. 2001. Plasma lipases and lipid transfer proteins increase phospholipid but not free cholesterol transfer from lipid emulsion to HDL. BMC Biochem. 2: 1-9.
24. Oliveira, H.C.F., and Quintao, E.C. 1996. In vitro cholesteryl ester bidirectional flow between high-density lipoproteins and triglyceride-rich emulsions: effects of particle concentration and composition, cholesteryl ester transfer activity and oleic acid. J. Biochem. Biophys. Methods 2: 45-57.
25. Paigen, B., Plump, A.S., and Rubin, E.M. 1994. The mouse as a model for human cardiovascular disease and hyperlipidemia. Curr. Opin. Lipidol. 5: 258-264.
26. Silva, R.M., Santos, F.A., Rao, V.S.N., Maciel, M.A.M., and Pinto, A.C. 2001a. The lipid-lowering effect of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara Benth. in mice fed on high-fat diet. J. Pharm. Pharmacol. 53: 535-539.
27. Silva, R.M., Santos, F.A., Maciel, M.A.M., Pinto, A.C., and Rao, V.S.N. 2001b. Effect of trans-dehydrocrotonin, a 19-norclerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 [Tyloxapol] in mice. Planta Med. 67: 763-765.
28. Silva, R.M., Santos, F.A., Rao, V.S.N., Maciel, M.A.M., and Pinto, A.C. 2001c. Blood glucose and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth. in rats. Diabetes Obes Metab, 3: 452-456.
29. Souza-Brito, A.R.M., Rodriguez, J.A., Hiruma-Lima, C.A., Haun, M., and Nunes, D.S. 1998. Antiulcerogenic activity of transdehydrocrotonin from Croton cajucara. Planta Med. 64: 126-129.
30. Tall, A.R. 1995. Plasma lipid transfer protein. Annu. Rev. Biochem. 64: 235-237.
31. Urizar, N.L., Liverman, A.B., Dodds, D.T., Silva, F.V., Ordentlich, P., Yan, Y. Gonzalez, F.J., Heyman, R.A., Mangelsdorf, D.J., and Moore, D.D. 2002. A natural product that lowers cholesterol as an antagonist ligant for FXR. Science, 296: 1703-1706.
32. Walsh, A., Azrolan, N., Wang, K., Marcigliano, A., O'Connell, A., and Breslow, J.L. 1993. Intestinal expression of the human apoA-1 gene in transgenic mice is controlled by a DNA region 3′ to the gene in the promoter of the adjacent convergently transcribed apoCIII gene. J. Lipid Res. 34: 617-623.
33. Wang, H.X., and Ng, T.B. 1999. Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities. Life Sci. 65: 2663-2677.