Cytotoxicity of derivatives from dehydrocrotonin on V79 cells and Escherichia coli

Toxicology

Volumn 159, Issue 3, 2001, Pages 135-141

  Da Silva Melo, Patricia ^a   Durán, Nelson ^a   Haun, Marcela ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cytotoxicity; Dehydrocrotonin; MTT; Neutral red; V79 fibroblasts

Indexed keywords

2 CYCLOHEXENONE; ANTIULCER AGENT; DEHYDROCROTONIN DERIVATIVE; DIMETHYLAMINE; LACTONE; NEUTRAL RED; NUCLEIC ACID; TETRAZOLIUM; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ARTICLE; BREATHING RATE; CELL STRAIN V 79; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ESCHERICHIA COLI; IC 50; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL COUNT; CELL LINE; CELL SURVIVAL; CRICETINAE; CRICETULUS; DITERPENES; DITERPENES, CLERODANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FIBROBLASTS; LUNG; NEUTRAL RED; NITROBLUE TETRAZOLIUM; NUCLEIC ACIDS; PLANTS, MEDICINAL; TOXICITY TESTS;

ESCHERICHIA COLI;

EID: 0035961446     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00417-0     Document Type: Article

References (27)

1. ™, im cultured rat hepatocytes and liver fractions
2. Cytotoxicity of okadaic acid and kinetic characterization of protein tyrosine phosphatase activity in V79 fibroblasts
3. The use of basal cytotoxicity and target organ toxicity tests in hazard identification and risk assessment
4. Cellular effects of an anionic surfactant detected in V79 fibroblasts by different cytotoxicity
5. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (Htd/NR 90)
6. Choice and standardization of test protocols in cytotoxicology: A multicentre approach
7. γ-keto and γ-hydroxy-γ-phenylbutyramides. Synthesis, absorption spectra and structure studies
8. Application of a multi-endpoint cytotoxicity assay to the trypanocidal compounds 2-propen-1-amine derivatives and determination of their acute toxicity
9. Rapid colorimetric assay for cell growth and survival, modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
10. 1
11. Comments on the use of diverse cell systems in toxicity testing
12. Toxicity testing with hepatocytes: Some methodological aspects
13. Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones
14. Anti-tumor activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara
15. Bacterial chemistry VI: Biological activities and cytotoxicity of 1,3-dihydro-2h-indol-2-one derivatives
16. Effects of an essential oil from the bark of Croton cajucara Benth. on experimental ulcer models in rats and mice
17. Nor-clerodane diterpenes from Croton cajucara
18. 2 production by flow injection analysis
19. Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays
20. The evaluation of a multi-endpoint citotoxicity assay system
21. Neutral red uptake, cellular growth and lysossomal function: In vitro effects of 24 metals
22. Cytotoxicity of trans-dehydrocrotonin from Croton cajucara on V79 cells and rat hepatocytes
23. Acute toxicity testing in vitro and the classification and labelling of chemicals
24. A novel synthetic method of the (+)-(3aα, 8aα)-ethyl 8β-hydroxy-6β-methyl-2-oxooctahydro-2-H-cyclohepata[b]furan- 3α-carboxylate and its chemical transformation to (+)-(3aα, 8aα)-3α,6β-dymethyl-3,3a,4,5,6,8a-hexahydro-2H-cyclohepta [b]furan-2-one, (+)- and 7β-(2-acetoxy-1α-methylethyl)-4β-methyl-2-cyclohepten- 1β-ol
25. Can the in vivo maximum tolerated dose be predicted using in vitro techniques? A working hypothesis
26. Anti-ulcerogenic activity of trans-dehydrocrotonin from Croton cajucara