Glucocorticoid action in development

Current Opinion in Endocrinology and Diabetes

Volumn 12, Issue 3, 2005, Pages 224-232

  Brown, Roger W ^a   Seckl, Jonathan R ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Fetal programming; Glucocorticoid; Liver; Lung; Pancreas

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR;

ADRENAL GLAND; ENZYME ACTIVITY; FETUS DEVELOPMENT; FETUS LUNG MATURITY; GENE EXPRESSION; GENE MAPPING; GESTATIONAL AGE; HORMONE ACTION; HORMONE METABOLISM; HORMONE SENSITIVITY; HUMAN; IN SITU HYBRIDIZATION; LIVER; LUNG; NONHUMAN; PANCREAS; PHYSICAL DEVELOPMENT; PLACENTA; PROTEIN EXPRESSION; REVIEW;

EID: 20444411197     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.med.0000162081.03216.e0     Document Type: Review

References (68)

1. Halliday HL. Use of steroids in the perinatal period. Paediatr Respir Rev 2004; 5(Suppl A):S321-S327.
2. McLaughlin KJ, Crowther CA, Walker N, Harding JE. Effects of a single course of corticosteroids given more than 7 days before birth: a systematic review. Aust N Z J Obstet Gynaecol 2003; 43:101-106.
3. Edwards CRW, Benediktsson R, Lindsay RS, Seckl JR. Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? Lancet 1993; 341:355-357.
4. Seckl JR. Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 2004; 151(Suppl 3):U49-U62. A comprehensive review of the role of glucocorticoids in programming and long-term disease vulnerability.
5. Arriza JL, Weinberger C, Cerelli G, et al. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 1987; 237:268-275.
6. Whorwood CB, Franklyn JA, Sheppard MC, Stewart PM. Tissue localization of 11beta-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor. J Steroid Biochem Mol Biol 1992; 41:21-28.
7. Brown RW, Chapman KE, Kotelevtsev Y, et al. Cloning and production of antisera to human placental 11beta-hydroxysteroid dehydrogenase type 2. Biochem J 1996; 313:1007-1017.
8. Rebuffat AG, Tam S, Nawrocki AR, et al. The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist. Mol Cell Endocrinol 2004; 214:27-37. This study indicates 11keto-dexamethasone is a specific GR agonist of comparable potency to dexamethasone or cortisol.
9. Bloomfield FH, Oliver MH, Hawkins P, et al. A periconceptional nutritional origin for noninfectious preterm birth. Science 2003; 300:606. (see comment)
10. Mastorakos G, Ilias I. Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum [review]. Ann N Y Acad Sci 2003; 997:136-149.
11. Brown RW, Diaz R, Robson AC, et al. The ontogeny of 11beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology 1996; 137:794-797.
12. Speirs HJ, Seckl JR, Brown RW. Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. J Endocrinol 2004; 181:105-116. A high fidelity, body-wide overview of GR and 11β-HSD1 gene expression changes in mouse development.
13. O'Rahilly RR, Muller F. Human embryology and teratology. 2nd ed. Hoboken, New Jersey: Wiley; 1996.
14. Lindsay RS, Lindsay RM, Edwards CRW, Seckl JR. Inhibition of 11beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension 1996; 27:1200-1204.
15. Mune T, Rogerson FM, Nikkila H, et al. Human hypertension caused by mutations in the kidney isozyme of 11beta-hydroxysteroid dehydrogenase. Nat Genet 1995; 10:394-399.
16. Zhang H, Hatta T, Ma L, et al. Acute in vivo effects of ACTH by exo utero microinjection on differentiation, steroidogenesis and proliferation of fetal mouse adrenocytes. Endocr Res 1999; 25:51-66.
17. Tyan ML. Sensitivity to corticosterone-induced cleft palate is not associated with H-2. Proc Soc Exp Biol Med 1984; 176:14-21.
18. Muglia L, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 1995; 373:427-432.
19. Venihaki M, Carrigan A, Dikkes P, Majzoub JA. Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc Natl Acad Sci USA 2000; 97:7336-7341.
20. Hundertmark S, Buhler H, Fromm M, et al. Ontogeny of 11beta- hydroxysteroid dehydrogenase: activity in the placenta, kidney, colon of fetal rats and rabbits. Horm Metab Res 2001; 33:78-83.
21. Murphy BE. Ontogeny of cortisol-cortisone interconversion in human tissues: a role for cortisone in human fetal development. J Steroid Biochem 1981; 14:811-817.
22. Murphy VE, Clifton VL. Alterations in human placental 11beta-hydroxysteroid dehydrogenase type 1 and 2 with gestational age and labour. Placenta 2003; 24:739-744.
23. Condon J, Gosden C, Gardener D, et al. Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. J Clin Endocrinol Metab 1998; 83:4490-4497.
24. Mellon SH, Compagnone N, Sander M, et al. Rodent models for studying steroids and hypertension: from fetal development to cells in culture [review]. Steroids 1995; 60:59-64.
25. Okamoto M, Takemori H, Halder SK, et al. Implication of ZOG protein (zona glomerulosa-specific protein) in zone development of the adrenal cortex. Endocr Res 1998; 24:515-520.
26. Ballard PL. Scientific rationale for the use of antenatal glucocorticoids to promote fetal development. Pediatr Rev 2000; 1:E83-E90.
27. Dodie M, Wintour EM. Effects of prolonged (48 h) infusion of cortisol on blood pressure, renal function and fetal fluids in the immature ovine foetus. Clin Exp Pharmacol Physiol 1994; 21:971-980.
28. Fowden AL, Forhead AJ. Endocrine mechanisms of intrauterine programming [review]. Reproduction 2004; 127:515-526. A good review of the still-emerging role of hormones (including glucocorticoids, insulin, insulin-like growth factor and thyroxine) in development relating to fetal programming.
29. Cole TJ, Blendy JA, Monaghan AP, et al. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev 1995; 9:1608-1621.
30. Kotelevtsev Y, Holmes MC, Burchell A, et al. 11beta-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 1997; 94:14924-14929.
31. Venihaki M, Carrigan A, Dikkes P, Majzoub JA. Orcadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc Natl Acad Sci USA 2000; 97:7336-7341.
32. Ward RM. Pharmacologic enhancement of fetal lung maturation [review]. Clin Perinatol 1994; 21:523-542.
33. Stewart JD, Sienko AE, Gonzalez CL, et al. Placebo-controlled comparison between a single dose and a multidose of betamethasone in accelerating lung maturation of mice offspring. Am J Obstet Gynecol 1998; 179: 1241-1247.
34. + and fluid clearance in later gestation.
35. Nakamura K, Stokes JB, McCray PB Jr. Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung. Am J Physiol Cell Physiol 2002; 283:C762-C772.
36. Mustafa SB, DiGeronimo RJ, Petershack JA, et al. Postnatal glucocorticoids induce alpha-ENaC formation and regulate glucocorticoid receptors in the preterm rabbit lung. Am J Physiol Lung Cell Mol Physiol 2004; 286: L73-L80.
37. Liu H, Hooper SB, Armugam A, et al. Aquaporin gene expression and regulation in the ovine fetal lung. J Physiol 2003; 551:503-514.
38. Cole TJ, Solomon NM, Van Driel R, et al. Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice. Am J Respir Cell Mol Biol 2004; 30:613-619. An elegant study defining the role of glucocorticoid action via GR in developing lung.
39. Mouhieddine-Gueddiche OB, Pinteur C, Chailley-Heu B, et al. Dexamethasone potentiates keratinocyte growth factor-stimulated SP-A and SP-B gene expression in alveolar epithelial cells. Pediatr Res 2003; 53:231-239.
40. Grier DG, Halliday HL. Effects of glucocorticoids on fetal and neonatal lung development. Treat Respir Med 2004; 3:295-306. Reviews maturational processes in lung and interaction of glucocorticoids with these.
41. Yoshida I, Ban N, Inagaki N. Expression of ABCA3, a causative gene for fatal surfactant deficiency, is up-regulated by glucocorticoids in lung alveolar type II cells. Biochem Biophys Res Commun 2004; 323:547-555.
42. Scavo LM, Newman V, Ertsey R, et al. Maternally administered dexamethasone transiently increases apoptosis in lungs of fetal rats. Exp Lung Res 2003; 29:211-226.
43. Tschanz SA, Makanya AN, Haenni B, Burri PH. Effects of neonatal high-dose short-term glucocorticoid treatment on the lung: a morphologic and morphometric study in the rat. Pediatr Res 2003; 53:72-80.
44. Clerch LB, Baras AS, Massaro GD, et al. DNA microarray analysis of neonatal mouse lung connects regulation of KDR with dexamethasone-induced inhibition of alveolar formation. Am J Physiol Lung Cell Mol Physiol 2004; 286:L41-L49. An interesting study finding balancing regulation of VEGF-R2 (KDR) by dexamethasone and retinoid signaling suggestive of a pathway with important potential influence over angiogenesis in developing lung.
45. Billat C, Mayeux P, Felix JM, Jacquot R. In vivo effects of glucocorticoid excess on the contents of the rat fetal liver in erythroid progenitors. Biol Neonate 1988; 53:47-52.
46. Leung P, Gidari AS. Glucocorticoids inhibit the growth of murine fetal liver erythroid burst-forming cells. Endocrinology 1982; 111:1121-1126.
47. Kinoshita T, Sekiguchi T, Xu MJ, et al. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci USA 1999; 96:7265-7270.
48. Matsunaga T, Maruyama M, Harada E, et al. Expression and induction of CYP3As in human fetal hepatocytes. Biochem Biophys Res Commun 2004; 318:428-434.
49. Nyirenda MJ, Welberg LA, Seckl JR. Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids: fetal effect or maternal influence? J Endocrinol 2001; 170:653-660.
50. El Khattabi I, Gregoire F, Remade C, Reusens B. Isocaloric maternal low-protein diet alters IGF-I, IGFBPs, and hepatocyte proliferation in the fetal rat. Am J Physiol Endocrinol Metab 2003; 285:E991-E1000.
51. Sienko AE, Stewart JD, Gonzalez CL, et al. Placebo-controlled, blinded comparison of antenatal betamethasone on mouse liver development. Drug Chem Toxicol 2001; 24:49-61.
52. Dodic M, Moritz K, Wintour EM. Prenatal exposure to glucocorticoids and adult disease. Arch Physiol Biochem 2003; 111:61-69.
53. Komatsu S, Yamamoto M, Arishima K, Eguchl Y. Maternal adrenocortical hormones maintain the early development of pancreatic B cells in the fetal rat. J Anat 1998; 193:551-557.
54. Lu RB, Lebenthal E, Lee PC. Developmental changes of glucocorticoid receptors in the rat pancreas. J Steroid Biochem 1987; 26:213-218.
55. Norman J, Franz M, Schiro R, et al. Functional glucocorticoid receptor modulates pancreatic carcinoma growth through an autocrine loop. J Surg Res 1994; 57:33-38.
56. Rosewicz S, Detjen K, Logsdon CD, et al. Glandular kallikrein gene expression is selectively down-regulated by glucocorticoids in pancreatic AR42J cells. Endocrinology 1991; 128:2216-2222.
57. Slater EP, Hesse H, Muller JM, Beato M. Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone. Mol Endocrinol 1993; 7:907-914.
58. Matthes H, Kaiser A, Stier U, et al. Glucocorticoid receptor gene expression in the exocrine and endocrine rat pancreas. Endocrinology 1994; 135:476-479.
59. Fischer B, Rausch U, Wollny P, et al. Immunohistochemical localization of the glucocorticoid receptor in pancreatic beta-cells of the rat. Endocrinology 1990; 126:2635-2641.
60. Johnson JWC, Mitzner W, Beck JC, et al. Long-term effects of betamethasone on fetal development. Am J Obstet Gynecol 1981; 141:1053-1064.
61. Habener JF, Kemp DM, Thomas MK. Transcriptional regulation in pancreatic development. Endocrinology 2005; 146:1025-1034. An excellent overview of this rapidly emerging field.
62. Gesina E, Tranche F, Herrera P, et al. Dissecting the role of glucocorticoids on pancreas development. Diabetes 2004; 53:2322-2329. Very elegant studies proving that glucocorticoid action on developing pancreas can affect long-term pancreatic endocrine capacity and so represents a potential mechanism programming impaired glucose tolerance.
63. Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004; 114:963-968.
64. Shen CN, Seckl JR, Slack JM, Tosh D. Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas. Biochem J 2003; 375:41-50.
65. Kulkarni RN, Jhala US, Winnay JN, et al. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 2004; 114:828-836. Shows Pdx-1 levels have important effects after birth also, limiting the ability of the endocrine pancreas to compensate for other causes of impaired glucose tolerance.
66. Stoffers DA, Ferrer J, Clarke WL, Habener JF. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 1997; 17:138-139.
67. Blondeau B, Lesage J, Czernichow P, et al. Glucocorticoids impair fetal beta-cell development in rats. Am J Physiol Endocrinol Metab 2001; 281:E592-E599.
68. Shen CN, Horb ME, Slack JM, Tosh D. Transdifferentiation of pancreas to liver [review]. Mech Dev 2003; 120:107-116.