Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor

European Journal of Pharmacology

Volumn 516, Issue 2, 2005, Pages 104-111

  Meini, Stefania ^a   Catalani, Claudio ^a   Bellucci, Francesca ^a   Cucchi, Paola ^a   Giuliani, Sandro ^a   Zappitelli, Sabrina ^a   Rotondaro, Luigi ^a   Pasqui, Franco ^b   Guidi, Antonio ^b   Altamura, Maria ^b   Giolitti, Alessandro ^b   Maggi, Carlo Alberto ^a  

^a Menarini Ricerche SpA   (Italy)

^b Menarini Biotech ^*  (Italy)

Author keywords

Binding site; G protein coupled receptor; Nonpeptide antagonist; Site directed mutagenesis; Tachykinin NK2 receptor isoform

Indexed keywords

INOSITOL PHOSPHATE; ISOPROTEIN; MEN 13510; N,N' BIS[2 (1H INDOL 3 YL)ETHYL] N,N' BIS(3 THIOMORPHOLIN 4 YLPROPYL)PHTHALAMIDE; NEPADUTANT; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ A; RADIOLIGAND; SAREDUTANT; THIOMORPHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AGONIST; AMINO ACID SUBSTITUTION; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHO CELL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN VARIANT; RECEPTOR AFFINITY;

ANIMALS; BENZAMIDES; BINDING, COMPETITIVE; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; INDOLES; INOSITOL PHOSPHATES; IODINE RADIOISOTOPES; LIGANDS; MORPHOLINES; MUTATION, MISSENSE; NEUROKININ A; PHTHALIC ACIDS; PIPERIDINES; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-2; SUBSTANCE P; TRITIUM;

EID: 20444398815     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.04.033     Document Type: Article

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