The acquisition of an insulin-secreting phenotype by HGF-treated rat pancreatic ductal cells (ARIP) is associated with the development of susceptibility to cytokine-induced apoptosis

Journal of Molecular Endocrinology

Volumn 34, Issue 2, 2005, Pages 367-376

  Anastasi, Emanuela ^c   Santangelo, C ^a   Bulotta, A ^b   Dotta, F ^c   Argenti, B ^c   Mincione, C ^c   Gulino, A ^c   Maroder, M ^c   Perfetti, R ^b   Di Mario, U ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; RNA; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CELL DIFFERENTIATION; CELL SECRETION; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; EXPOSURE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC REGULATION; GENETIC TRANSCRIPTION; INCUBATION TIME; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOLECULAR MECHANICS; NICK END LABELING; NONHUMAN; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; RAT; RNA TRANSLATION;

ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLUCOSE; HEPATOCYTE GROWTH FACTOR; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; PANCREATIC DUCTS; PHENOTYPE; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; TRANSCRIPTION FACTORS;

EID: 20244390437     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.01595     Document Type: Article

References (43)

1. Anastasi E, Ponte E, Gradini R, Bulotta A, Sale P, Tiberti C, Okamoto H, Dotta F & Di Mario U 1999 Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes. European Journal of Endocrinology 141 644-652.
2. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U & Edlund H 1999 Notch signalling controls pancreatic cell differentiation. Nature 26 877-881.
3. Argiles JM, Lopez-Soriano J, Ortiz MA, Pou JM & Lopez-Soriano FJ 1992 Interleukin-1 and beta-cell function: more than one second messenger? Endocrine Reviews 13 515-524.
4. Baron M, Aslam H, Flasza M, Fostier M, Higgs JE, Mazaleyrat SL & Wilkin MB 2002 Multiple levels of Notch signal regulation (review). Molecular Membrane Biology 19 27-38.
5. Bonner-Weir S, Baxter LA, Schuppin GT & Smith FE 1993 A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 42 1715-1720.
6. Bouwens L 1998 Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microscopy Research and Technique 43 332-336.
7. Brand SJ, Tagerud S, Lambert P, Magil SG, Tatarkiewicz K, Doiron K & Yan Y 2002 Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin. Pharmacology and Toxicology 91 414-420.
8. Bulotta A, Di Cesare E, Ponte E, Falchi M, Sciacchitano S, Cucinotta D, Taruscio D, Di Mario U & Anastasi E 2001 Increased c-met expression during ductal beta cell neogenesis in experimental autoimmune diabetes. Growth Factors 19 259-267.
9. Calvo B, Boucher C, Pelletier G & Morisset J 1996 Ontogeny of hepatocyte growth factor and c-met/HGF receptor in rat pancreas. Biochemical and Biophysical Research Communications 229 257-263.
10. Chakrabarti SK & Mirmira RG 2003 Transcription factors direct the development and function of pancreatic β cells. Trends in Endocrinology and Metabolism 2 78-84.
11. Corbett JA & McDaniel ML 1992 Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. Diabetes 41 897-903.
12. Delaney CA, Pavlovich D, Hoorens A, Pipeleers DG & Eizirik DL 1997 Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138 2610-2614.
13. Edlund H 2002 Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nature Reviews Genetics 3 524-532.
14. Egan JM, Bulotta A, Hui H & Perfetti R 2003 GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metabolism Research and Reviews 19 115-123.
15. Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A & Screpanti I 1999 Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. International Immunology 11 1017-1025.
16. Gahr S, Merger M, Bollheimer LC, Hammerschmied CG, Schölmerich J & Hügl SR 2002 Hepatocyte growth factor stimulates proliferation of pancreatic β-cells particularly in the presence of subphysiological glucose concentrations. Journal of Molecular Endocrinology 28 99-110.
17. García-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC & Stewart AF 2000 Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. Journal of Biological Chemistry 275 1226-1232.
18. Gradwohl G, Dierich A, LeMeur M & Guillemot F 2000 Neurogenin 3 is required for the development of the four endocrine cell lineages of the pancreas. PNAS 97 1607-1611.
19. Guidos CJ 2002 Notch signaling in lymphocyte development. Seminars in Immunology 14 395-404.
20. Hardikar AA 2004 Generating new pancreas from old. Trends in Endocrinology and Metabolism 5 198-203.
21. Heremans Y, Van De Casteele M, Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D & Heimberg H 2002 Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. Journal of Cell Biology 159 303-311.
22. Hui H, Wright C & Perfetti R 2001 Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 50 785-796.
23. Kobayashi S, Akiyama T, Nata K, Abe M, Tajima M, Shervani NJ, Unno M, Matsuno S, Sasaki H, Takasawa S & Okamoto H 2000 Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. Journal of Biological Chemistry 275 10723-10726.
24. Lewis J 1998 Notch signaling and the control of cell fate choices in vertebrates. Seminars in Cell and Developmental Biology 9 583-589.
25. Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R & Marchetti P 2001 Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. Journal of Clinical Endocrinology and Metabolism 86 4974-4978.
26. Mashima H, Shibata H, Mine T & Kojima I 1996 Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology 137 3969-3976.
27. Medh RD & Thompson EB 2000 Hormonal regulation of physiological cell turnover and apoptosis. Cell and Tissue Research 301 101-124.
28. Mumm JS & Kopan R 2000 Notch signaling: from the outside in. Developmental Biology 228 151-165.
29. Osterhout DJ, Marin-Husstege M, Abano P & Casaccia-Bonnefil P 2002 Molecular mechanisms of enhanced susceptibility to apoptosis in differentiating oligodendrocytes. Journal of Neuroscience Research 69 24-29.
30. Otonkoski T, Beattie GM, Lopez AD & Hayek A 1994a Use of hepatocyte growth factor/scatter factor to increase transplantable human fetal islet cell mass. Transplantation Proceedings 26 3334.
31. Otonkoski T, Beattie GM, Rubin JS, Lopez AD, Baird A & Hayek A 1994b Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 43 947-953.
32. Otonkoski T, Cirulli V, Beattie M, Mally MI, Soto G, Rubin JS & Hayek A 1996 A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth. Endocrinology 137 3131-3139.
33. Rabinovitch A & Suarez-Pinzon WL 1998 Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochemical Pharmacology 55 1139-1149.
34. Risbud MV & Bhonde RR 2002 Models of pancreatic regeneration in diabetes. Diabetes Research and Clinical Practice 58 155-165.
35. Sandler S, Eizirik DL, Sternesjo J & Welsh N 1994 Role of cytokines in regulation of pancreatic B-cell function. Biochemical Society Transactions 22 26-30.
36. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD & German MS 2000 Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127 3533-3542.
37. Sonnenberg E, Meyer D, Weidner KM & Birchmeier C 1993 Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia between during mouse development. Journal of Cell Biology 1 223-235.
38. Stassi G, Maria RD, Rudert W, Testi R, Galluzzo A, Giordano C & Trucco M 1997 Nitric oxide primes pancreatic b-cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. Journal of Experimental Medicine 186 1193-1200.
39. Teitelman G & Lee JK 1987 Cell lineage analysis of pancreatic islet development: glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct. Developmental Biology 121 454-466.
40. Wagers AJ, Christensen JL & Weissman IL 2002 Cell fate determination from stem cells. Gene Therapy 9 606-612.
41. Wilson ME, Scheel D & German MS 2003 Gene expression cascade in pancreatic development. Mechanism in Development 120 65-80.
42. Wucherpfennig KW & Eisenbarth GS 2001 Type 1 diabetes. Nature Immunology 2 767-768.
43. Yoon JW & Jun HS 2001 Cellular and molecular pathogenetic mechanisms of insulin dependent diabetes mellitus. Annals of the New York Academy of Sciences 928 200-211.