The conserved residue Phe273(282) of PPARα(γ), beyond the ligand-binding site, functions in binding affinity through solvation effect

Biochimie

Volumn 87, Issue 6, 2005, Pages 539-550

  Yue, Liduo ^a   Ye, Fei ^a   Xu, Xiaoying ^a   Shen, Jianhua ^a   Chen, Kaixian ^a   Shen, Xu ^a   Jiang, Hualiang ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Ligand binding affinity; Molecular dynamics; Mutation; Peroxisome proliferator activated receptor (PPAR); Solvation effect; Surface plamon resonance (SPR); Transcriptional activation

Indexed keywords

ALANINE; FARGLITAZAR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENYLALANINE; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; HYDROGEN BOND; LIGAND BINDING; MUTATION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIMULATION; SOLVATION; SURFACE PLASMON RESONANCE; TRANSCRIPTION INITIATION; WILD TYPE;

AMINO ACID SEQUENCE; BINDING SITES; HUMANS; LIGANDS; PHENYLALANINE; POINT MUTATION; PPAR ALPHA; PPAR GAMMA; SURFACE PLASMON RESONANCE; TRANS-ACTIVATION (GENETICS);

EID: 20144373752     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biochi.2005.02.002     Document Type: Article

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