메뉴 건너뛰기




Volumn 230, Issue 1-2, 1999, Pages 59-70

Efficient laboratory-scale production of monoclonal antibodies using membrane-based high-density cell culture technology

Author keywords

Affinity purification; Bovine Ig contamination; CELLine high density cell culture device; MAb activity; Monoclonal antibody production; Serum free media

Indexed keywords

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

EID: 0032758496     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(99)00122-2     Document Type: Article
Times cited : (41)

References (21)
  • 1
    • 0032324029 scopus 로고    scopus 로고
    • In vivo and in vitro production of monoclonal antibodies: Current possibilities and future perspectives, 74th Forum in immunology
    • De Geus B., Hendriksen C.F.M. In vivo and in vitro production of monoclonal antibodies: current possibilities and future perspectives, 74th Forum in immunology. Res. Immunol. 149:1998;533.
    • (1998) Res. Immunol. , vol.149 , pp. 533
    • De Geus, B.1    Hendriksen, C.F.M.2
  • 2
    • 0032109038 scopus 로고    scopus 로고
    • Monoclonal antibody production: Problems and solutions
    • Falkenberg F.W. Monoclonal antibody production: problems and solutions. Res. Immunol. 149:1998;542.
    • (1998) Res. Immunol. , vol.149 , pp. 542
    • Falkenberg, F.W.1
  • 3
    • 0028795242 scopus 로고
    • In vitro production of monoclonal antibodies in high concentration in a new and easy to handle modular minifermentor
    • Falkenberg F.W., Weichert H., Krane M., Bartels I., Palme M., Nagels H.-O., Fiebig H. In vitro production of monoclonal antibodies in high concentration in a new and easy to handle modular minifermentor. J. Immunol. Methods. 179:1995;13.
    • (1995) J. Immunol. Methods , vol.179 , pp. 13
    • Falkenberg, F.W.1    Weichert, H.2    Krane, M.3    Bartels, I.4    Palme, M.5    Nagels, H.-O.6    Fiebig, H.7
  • 4
    • 0025700415 scopus 로고
    • The loss of antibody productivity in continuous culture of hybridoma cells
    • Frame K.K., Hu W.-S. The loss of antibody productivity in continuous culture of hybridoma cells. Biotechnol. Bioeng. 35:1990;469.
    • (1990) Biotechnol. Bioeng. , vol.35 , pp. 469
    • Frame, K.K.1    Hu, W.-S.2
  • 5
    • 0032109031 scopus 로고    scopus 로고
    • Production of monoclonal antibodies by the ascites method in laboratory animals
    • Hendriksen C.F.M., De Leeuw W. Production of monoclonal antibodies by the ascites method in laboratory animals. Res. Immunol. 149:1998;535.
    • (1998) Res. Immunol. , vol.149 , pp. 535
    • Hendriksen, C.F.M.1    De Leeuw, W.2
  • 8
    • 0029864893 scopus 로고    scopus 로고
    • Evaluation of hollow fiber bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production
    • Jackson L.R., Trudel L.J., Fox J.G., Lipman N.S. Evaluation of hollow fiber bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production. J. Immunol. Methods. 189:1996;217.
    • (1996) J. Immunol. Methods , vol.189 , pp. 217
    • Jackson, L.R.1    Trudel, L.J.2    Fox, J.G.3    Lipman, N.S.4
  • 10
    • 0016756272 scopus 로고
    • Continuous culture of fused cells secreting antibody with predefined specificity
    • Köhler G., Milstein C. continuous culture of fused cells secreting antibody with predefined specificity. Nature. 256:1975;495.
    • (1975) Nature , vol.256 , pp. 495
    • Köhler, G.1    Milstein, C.2
  • 12
    • 0030662181 scopus 로고    scopus 로고
    • Production of highly pure monoclonal antibodies without purification using a hollow fiber bioreactor
    • Kreutz F.T., Jafarin A., Biggs D.F., Suresh M.R. Production of highly pure monoclonal antibodies without purification using a hollow fiber bioreactor. Hybridoma. 16:1997;485.
    • (1997) Hybridoma , vol.16 , pp. 485
    • Kreutz, F.T.1    Jafarin, A.2    Biggs, D.F.3    Suresh, M.R.4
  • 13
    • 0031934479 scopus 로고    scopus 로고
    • Generation of murine monoclonal antibodies in serum-free medium
    • Liu R.-S., Ta D., Payne J., Coccia M., Kuus-Reichel K. Generation of murine monoclonal antibodies in serum-free medium. Hybridoma. 17:1998;69.
    • (1998) Hybridoma , vol.17 , pp. 69
    • Liu, R.-S.1    Ta, D.2    Payne, J.3    Coccia, M.4    Kuus-Reichel, K.5
  • 14
    • 0028017817 scopus 로고
    • A comparison of monoclonal antibody productivity in different hollow fiber bioreactors
    • Lowrey D., Murphy S., Goffe R.A. A comparison of monoclonal antibody productivity in different hollow fiber bioreactors. J. Biotech. 36:1994;35.
    • (1994) J. Biotech. , vol.36 , pp. 35
    • Lowrey, D.1    Murphy, S.2    Goffe, R.A.3
  • 15
    • 0032109046 scopus 로고    scopus 로고
    • Membrane-based cell culture technologies: A scientifically and economically satisfactory alternative to malignant ascites production for monoclonal antibodies
    • Marx U. Membrane-based cell culture technologies: a scientifically and economically satisfactory alternative to malignant ascites production for monoclonal antibodies. Res. Immunol. 149:1998;557.
    • (1998) Res. Immunol. , vol.149 , pp. 557
    • Marx, U.1
  • 16
    • 0028099852 scopus 로고
    • Multiparametric analyses of hybridoma growth on glass cylinders in a packed-bed bioreactor system with internal aeration. Serum-supplemented and serum-free media comparison for MAb production
    • Moro A.M., Alves Rodrigues M.T., Nakamura Gouvea M., Zucheran Silvestri M.L., Kalil J.E., Raw I. Multiparametric analyses of hybridoma growth on glass cylinders in a packed-bed bioreactor system with internal aeration. Serum-supplemented and serum-free media comparison for MAb production. J. Immunol. Methods. 176:1994;67.
    • (1994) J. Immunol. Methods , vol.176 , pp. 67
    • Moro, A.M.1    Alves Rodrigues, M.T.2    Nakamura Gouvea, M.3    Zucheran Silvestri, M.L.4    Kalil, J.E.5    Raw, I.6
  • 17
    • 0025305013 scopus 로고
    • Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum-free media
    • Ozturc S.S., Palsson B.O. Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum-free media. Hybridoma. 9:1990;167.
    • (1990) Hybridoma , vol.9 , pp. 167
    • Ozturc, S.S.1    Palsson, B.O.2
  • 18
    • 0028871804 scopus 로고
    • How to measure and predict the molar absorption coefficient of a protein
    • Pace C.N., Vajdos F., Fee L., Grimsley G., Gray T. How to measure and predict the molar absorption coefficient of a protein. Protein Science. 4:1995;2411.
    • (1995) Protein Science , vol.4 , pp. 2411
    • Pace, C.N.1    Vajdos, F.2    Fee, L.3    Grimsley, G.4    Gray, T.5
  • 19
    • 0003132194 scopus 로고
    • Radioimmunodetection of human tumor xenografts by monoclonal antibodies correlates with antibody density and affinity
    • In: Button, K., Donato, L., (Eds.), Gordon and Breach Science Publishers, New York
    • Powe, J., Herlyn, D., Alavi, A., Munz, D., Steplewski, Z., Koprowski, H., 1985. Radioimmunodetection of human tumor xenografts by monoclonal antibodies correlates with antibody density and affinity. In: Button, K., Donato, L., (Eds.), Immunoscintigraphy, Gordon and Breach Science Publishers, New York, pp. 135.
    • (1985) Immunoscintigraphy , pp. 135
    • Powe, J.1    Herlyn, D.2    Alavi, A.3    Munz, D.4    Steplewski, Z.5    Koprowski, H.6
  • 20
    • 0023472472 scopus 로고
    • Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
    • Schägger H., Von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:1987;368.
    • (1987) Anal. Biochem. , vol.166 , pp. 368
    • Schägger, H.1    Von Jagow, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.