Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas

Clinical Cancer Research

Volumn 4, Issue 7, 1998, Pages 1619-1624

  Takao, Sonshin ^a   Takebayashi, Yuji ^a,b   Che, Xiangming ^a,c   Shinchi, Hiroyuki ^a   Natsugoe, Shouji ^a   Miyadera, Kazutaka ^d   Yamada, Yuji ^d   Akiyama, Shinichi ^a   Aikou, Takashi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c XI'AN MEDICAL UNIVERSITY   (China)

^d TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; THYMIDINE PHOSPHORYLASE;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; PROGNOSIS; THYMIDINE PHOSPHORYLASE;

EID: 0031777632     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Iltzssch, M. H., Kouni, M. H., and Cha, S. Kinetic studies of thymidine phosphorylase from mouse liver. Biochemistry, 24: 6799-6807, 1985.
2. Friedkin, D., and Roberts, D. The enzymatic synthesis of nucleosides. J. Biol. Chem., 207: 245-256, 1954.
3. Krenistsky, T. A., Koszalka, G. W., and Turttle, J. V. Purine nucleoside synthesis, an efficient method employing nucleoside phosphorylase. Biochemistry, 20: 3615-3621, 1981.
4. Zimmerman, M., and Seidenberg, J. Deoxyribosyl transfer. J. Biol. Chem., 230: 2618-2621, 1964.
5. Gallo, R. C., Perry, S., and Breitman, T. R. The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes. J. Biol. Chem., 242: 5059-5068, 1967.
6. Krenitsky, T. A. Pentosyl transfer mechanisms of the mammalian nucleoside phosphorylases. J. Biol. Chem., 243: 2871-2875, 1968.
7. Desgranges, C., Razaka, G., and Rabaud, H. Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase. Biochim. Biophys. Acta, 654: 211-218, 1981.
8. Furukawa, T., Yoshimura, A., Sumizawa, T., Haraguchi, M., Akiyama, S., Fukui, K., Ishizawa, M., and Yamada, Y. Angiogenic factor. Nature (Lond.), 356: 668, 1992.
9. Sumizawa, T., Furukawa, T., Haraguchi, M., Fukui, K., Ishizawa, M., and Akiyama, S. Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor. J. Biochem. (Tokyo), 114: 9-14, 1993.
10. Haraguchi, M., Miyadera, K., Uemura, K., Sumizawa, T., Furukawa, T., Yamada, K., Akiyama, S., and Yamada, Y. Angiogenic activity of enzymes. Nature (Lond.), 368: 198, 1994.
11. Ishikawa, F., Miyazono, K., Hellman, U., Drexler, M., Wernstedt, C., Hagiwara, K., Usuki, K., Takaku, F., Risau, W., and Heldin, C. H. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (Lond.), 338: 556-562, 1989.
12. Miyazono, K., Okabe, T., Urabe, A., Takaku, F., and Heldin, C. H. Purification and properties of an endothelial cell growth factor from human platelets. J. Biol. Chem., 262: 4098-4103, 1987.
13. Miyadera, K., Sumizawa, T., Haraguchi, M., Yoshida, H., Konstanty, W., Yamada, Y., and Akiyama, S. Role of thymidine phosphorylase activity in the angiogenic effect of platelet-derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res., 55: 1687-1690, 1995.
14. Moghaddam, A., Zhang, H. T., Fan, T. P. D., Hu, D. E., Lees, V. C., Turley, H., Fox, S. B., Gatter, K. C., Harris, A. L., and Bicknell, R. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc. Natl. Acad. Sci. USA, 92: 998-1002, 1995.
15. Toi, M., Hoshina, S., Taniguchi, T., Yamamoto, Y., Ishituka, H., and Tominaga, T. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int. J. Cancer, 14: 79-82, 1995.
16. Reynold, K., Farzaneh, F., Collins, W. P., and Harris, A. L. Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor. J. Natl. Cancer Inst., 86: 1234-1238, 1994.
17. Pauly, J. L., Schuller, M. G., Zelcer, A. A., Kris, T. A., and Gore, S. S. Identification and comparative analysis of thymidine phosphorylase in the plasma of healthy subjects and cancer patients: brief communication. J. Natl. Cancer Inst., 58: 1587-1590, 1977.
18. Kono, A., Hara, Y., Sugata, S., Matsushima, Y., and Ueda, T. Substrate specificity of a thymidine phosphorylase in human liver tumor. Chem. Pharm. Bull. (Tokyo), 32: 1919-1921, 1984.
19. Yoshimura, A., Kuwazuru, Y., Furukawa, T., Yoshida, H., Yamada, K., and Akiyama, S. Purification and tissue distribution of human thymidine phosphorylase: high expression in lymphocytes, reticulocytes and tumors. Biochim. Biophys. Acta, 1034: 107-113, 1990.
20. Takebayashi, Y., Yamada, K., Maruyama, I., Fujii, R., Akiyama, S., and Aikou, T. The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas. Cancer Lett., 92: 1-7, 1995,
21. O'Brien, T, Cranston, D., Fuggle, S., Bicknell, R., and Harris, A. L. Different angiogenic pathways characterize superficial and invasive bladder cancer. Cancer Res., 55: 510-513, 1995.
22. Takebayashi, Y., Yamada, K., Miyadera, K., Sumizawa, T., Furukawa, T., Kinoshita, F., Aoki, D., Okumura, H., Yamada, Y., Akiyama, S., and Aikou, T. The activity and expression of thymidine phosphorylase in human solid tumors. Eur. J. Cancer, 32: 1227-1232, 1996.
23. Takebayashi, Y., Miyadera, K., Akiyama, S., Hokita, S., Yamada, Y., Akiba, S., Yamada, Y., Sumizawa, T., and Aikou, T. Expression of thymidine phosphorylase in human gastric carcinoma. Jpn. J. Cancer Res., 87: 288-295, 1996.
24. Maeda, K., Chung, Y. S., Ogawa, Y., Takatsuka, S., Rang, S. M., Ogawa, M., Sawada, T., Onda, N., Kato, Y., and Sowa, M. Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma. Br. J. Cancer, 73: 884-888, 1996.
25. Takebayashi, Y., Akiyama, S., Akiba, S., Yamada, K., Miyadera, K., Sumizawa, T., Yamada, Y., Murata, F., and Aikou, T. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J. Natl. Cancer Inst., 88: 1110-1117, 1996.
26. Folkman, J., and Klagsbrun, M. Angiogenic factor. Science (Washington DC), 235: 442-447, 1987.
27. Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4-6, 1990.
28. Liotta, L., Kleinerman, J., and Saidel, G. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary mtastases following tumor implantation. Cancer Res., 34: 997-1004, 1974.
29. Srivastava, A., Laidler, P., Hughes, L. E., Woodcock, J., and Shedden, E. J. Neovascularization in human cutaneous melanoma: a quantitative morphological and Doppler ultrasound study. Eur. J. Cancer Clin. Oncol., 22: 1205-1209, 1986.
30. Srivastava, A., Laidler, P., Davis, R. P., Horgan, K., and Hughes, L. E. The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma: a quantitative histologic study. Am. J. Pathol., 133: 419-423, 1988.
31. Herlyn, M., Clark, W. H., Rodeck, U., Mancianti, M. L., Jambrosic, I., and Koprowski, H. Biology of tumor progression in human melanocytes. Lab Investig., 56: 461-474, 1987.
32. Weidner, N., Semple, J. P., Welch, W. R., and Folkman, J. Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N. Engl. J. Med., 324: 1-8, 1991.
33. Horak, E. R., Leek, R., Klenk, N., Lejeune, S., Smith, K., Stuart, N., and Harris, A. L. Angiogenesis, assessed by platelet-derived cell adhesion molecular antibodies, as indicator of node metastases and survival in breast cancer. Lancet, 340: 1120-1124, 1992.
34. Weidner, N., Carroll, P. R., Flax, J., Blumenfeld, W., and Folkman, J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol., 143: 401-409, 1993.
35. Macchiarini, P., Fontanini, G., Hardin, M. J., Squartini, F., and Angeletti, C. A. Relation of neovascularization to metastasis of non-small-cell lung cancer. Lancet, 340: 145-146, 1992.
36. Yamazaki, K., Abe, S., Takekawa, H., Sudou, N., Watanabe, N., and Ogura, S. Tumor angiogenesis in human lung adenocarcinoma. Cancer (Phila.), 74: 2245-2250, 1995.
37. Maeda, K., Chung, Y. S., Ogawa, Y., Takatsuka, S., Rang, S. M., Ogawa, M., Sawada, T., and Sowa, M. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer (Phila.), 77: 858-863, 1996.
38. Takebayashi, Y., Akiyama, S., Yamada, K., Akiba, S., and Aikou, T. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma. Cancer (Phila.), 78: 226-231, 1996.
39. Hunstad, D. A., and Norton, J. A. Management of pancreatic cancer. Surg. Oncol., 4: 61-74, 1995.
40. Warshaw, A. L., and Fernandez-del Castillo, C. Pancreatic carcinoma. N. Engl. J. Med., 326: 455-465, 1992.
41. Conlon, K. C., Klimstra, D. S., and Brennan, M. F. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Ann. Surg., 223: 273-279, 1996.
42. Hermanek, P., and Sobin, L. H. (eds.). UICC TNM Classification of Malignant Tumors, 4th ed. Berlin: Springer Verlag, 1992.
43. Hsu, S. M., Raine, L., and Fanger, A. H. A comparative study of the peroxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibody. Am. J. Clin. Pathol., 75: 734-738, 1981.
44. Lee, T. E. Statistical Methods for Survival Data Analysis. 2nd ed. New York: John Wiley & Sons. 1992.
45. Usuki, K., Saras, J., Waltenberger, J., Miyazono, K., Pierce, G., Thomason, A., and Heldin, C. H. Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem. Biophys. Res. Commun., 184: 1311-1314, 1992.
46. Moghaddam, A., and Bicknell, R. Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry, 31: 12141-12146. 1992.
47. Nishimoto, K., Miyadera, K., Takebayashi, Y., Fukuda, K., Haraguchi, M., Fumkawa, T., Yamada, Y., and Akiyama, S. Thymidine phosphorylase activity required for tumor angiogenesis and growth. Oncol. Rep., 4: 55-58. 1997.
48. Fox, S. B., Westwood, M., Moghaddam, A., Comely, M., Turley, H., Whitehouse, R. M., Bicknell, R., Gatter, K. C., and Harris, A. L. The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium. Br. J. Cancer, 73: 275-280, 1996.
49. Takebayashi, Y., Akiyama, S., Tani, A., Haraguchi, M., Furukawa, T., Miyadera, K., Yamada, Y., and Aikou, T. Induction of thymidine phosphorylase by hypoxia and relationship between expression of thymidine phosphorylase and apoptosis. Proc. Am. Assoc. Cancer Res., 38: 48, 1997.