Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis

European Journal of Cancer

Volumn 34, Issue 9, 1998, Pages 1439-1447

  Fujimoto, K ^a   Hosotani, R ^a   Wada, M ^a   Lee, J U ^a   Koshiba, T ^a   Miyamoto, Y ^a   Tsuji, S ^a   Nakajima, S ^a   Doi, R ^a   Imamura, M ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Microvessel density; Pancreatic cancer; Platelet derived endothelial cell growth factor (PD ECGF); RT PCR; Vascular endothelial growth factor (VEGF); Western blot

Indexed keywords

ANGIOGENIC FACTOR; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; VASCULOTROPIN;

ADULT; ANGIOGENESIS; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; DIAGNOSTIC VALUE; FEMALE; HUMAN; MALE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR BLOOD FLOW;

BLOTTING, WESTERN; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; LYMPHOKINES; MALE; MICROCIRCULATION; MIDDLE AGED; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMIDINE PHOSPHORYLASE; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032146088     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(98)00069-0     Document Type: Article

References (41)

1. 1. Folkman J. What is the evidence that tumors are angiogenesis dependent? [editorial]. J Natl Cancer Inst 1990, 82, 4-6.
2. 2. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995, 55, 3964-3968.
3. 3. Bochner BH, Cote RJ, Weidner N, et al. Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J Natl Cancer Inst 1995, 87, 1603-1612.
4. 4. Tanigawa N, Amaya H, Matsumura M, et al. Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinomas. Cancer Res 1996, 56, 2671-2676.
5. 5. Gasparini G. Angiogenesis research up to 1996. A commentary on the state of art and suggestions for future studies. Eur J Cancer 1996, 32A(14), 2379-2385.
6. 6. Gasparini G. Clinical significance of the determination of angiogenesis in human breast cancer: update of the biological background and overview of the Vicenza studies. Eur J Cancer 1996, 32A(14), 2485-2493.
7. 7. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989, 161, 851-858.
8. 8. Viglietto G, Romano A, Maglione D, et al. Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor. Oncogene 1996, 13, 577-587.
9. 9. Takebayashi Y, Akiyama S, Akiba S, et al. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phophorylase, in human colorectal carcinoma. J Natl Cancer Inst 1996, 88, 1110-1117.
10. 10. Takahashi Y, Bucana CD, Liu W, et al. Platelet-derived endothelial cell growth factor in human cancer angiogenesis: role of infiltrating cells. J Natl Cancer Inst 1996, 88, 1146-1151.
11. 11. Mise M, Arii S, Higashituji H, et al. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996, 23, 455-464.
12. 12. Koukourakis MI, Giatromanolaki A, O'Byrne M, et al. Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer. Br J Cancer 1997, 75, 477-481.
13. 13. Rosenberg JM, Welch JP, Macaulay WP. Cancer of the head of the pancreas. J Surg Oncol 1985, 28, 217-221.
14. 14. Egawa S, Tsutsumi M, Konishi Y, et al. The role of angiogenesis in the tumor growth of Syrian hamster pancreatic cancer cell line HPD-NR. Gastroenterology 1995, 108, 1526-1533.
15. 15. Toi M, Inada K, Hoshina S, Suzuki H, Konda S, Tominaga T. Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer. Clin Cancer Res 1995, 1, 961-964.
16. 16. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359, 843-845.
17. 17. Griffiths L, Dachs GU, Bicknell R, Harris AL, Stratford IJ. The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo. Cancer Res 1997, 57, 570-572.
18. 18. Larcher F, Robles Al, Duran H, et al. Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res 1996, 56, 5391-5396.
19. 19. Enholm B, Paavonen K, Ristimaki A, et al. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 1997, 14, 2475-2483.
20. 20. White FC, Benehacene A, Scheele JS, Kamps M. VEGF mRNA is stabilized by ras and tyrosine kinase oncogenes, as well as by UV radiation-evidence for divergent stabilization pathways. Growth Factors 1997, 14, 199-212.
21. 21. Hosoki T. Dynamic CT of pancreatic tumors. AJR 1983, 140, 959-965.
22. 22. Gansauge S, Gansauge F, Beger HG. Molecular oncology in pancreatic cancer. J Mol Med 1996, 74, 313-320.
23. 23. Sobin L, Wittekind C, eds. UICC TNM Classification of Malignant Tumours. Berlin, Springer, 1997.
24. 24. Takebayashi Y, Yamada K, Miyadera K, et al. The activity and expression of thymidine phosphorylase in human solid tumors. Eur J Cancer 1996, 32A(7), 1227-1232.
25. 25. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Eng J Med 1991, 324, 1-8.
26. 26. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Biochem 1976, 72, 248-254.
27. 27. Tisher E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991, 266, 11947-11954.
28. 28. Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrine Rev 1992, 13, 18-32.
29. 29. Hollingsworth HC, Kohn EC, Steinberg SM, Rothenberg ML, Merino MJ. Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 1995, 147, 33-41.
30. 30. Bossi P, Viale G, Lee AK, Alfano R, Coggi G, Bosari S. Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. Cancer Res 1995, 55, 5049-5053.
31. 31. Mooteri S, Rubin D, Leurgans S, Jakate S, Drab E, Saclarides T. Tumor angiogenesis in primary and metastatic colorectal cancers. Dis Colon Rectum 1996, 39, 1073-1080.
32. 32. Connolly DT, Heuvelman DM, Nelson R, et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 1989, 84, 1470-1478.
33. 33. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246, 1306-1309.
34. 34. Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 1989, 338, 557-562.
35. 35. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K. Angiogenic factor [letter]. Nature 1992, 356, 668.
36. 36. Haraguchi M, Miyadera K, Uemura K, et al. Angiogenic activity of enzymes. Nature (London) 1994, 368, 198.
37. 37. Folkman J. What is the role of thymidine phosphorylase in tumor angiogenesis? [Editorial]. Natl Cancer Inst J 1996, 88, 1091-1092.
38. 38. Relf M, Lejeune S, Scott PAE, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor B-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997, 57, 963-969.
39. 39. Inoue K, Ozeki Y, Suganuma T, Sugiura Y, Tanaka S. Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer 1997, 79, 206-213.
40. 40. Oberg-Welsh C, Sandler S, Anderson A, Welsh M. Effects of VEGF in pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vivo. Mol Cell Endocrinol 1997, 126, 125-132.
41. 41. Rooman I, Schuit F, Bouwens L. Effects of VEGF on growth and differentiation of pancreatic ductal epithelium. Lab Invest 1997, 76, 225-232.