Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line

Placenta

Volumn 26, Issue 10, 2005, Pages 721-728

  Weedon Fekjaer, M S ^a   Duttaroy, A K ^a   Nebb, H I ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

BeWo cells; hCG; Lipid synthesis; LXR; Placenta; SREBP 1

Indexed keywords

CHORIONIC GONADOTROPIN; FATTY ACID SYNTHASE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HORMONE RELEASE; HUMAN; HUMAN CELL; LIPOGENESIS; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TROPHOBLAST;

BLOTTING, NORTHERN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHORIONIC GONADOTROPIN; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; HYDROXYCHOLESTEROLS; LIPIDS; PREGNANCY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDES; TRANSFECTION; TROPHOBLASTS;

EID: 20144363133     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2004.10.005     Document Type: Article

References (47)

1. R.A. Coleman The role of the placenta in lipid metabolism and transport Semin Perinatol 13 1989 180-191
2. A.K. Duttaroy Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta Am J Clin Nutr 71 2000 315S-322S
3. G.T. Knipp K.L. Audus M.J. Soares Nutrient transport across the placenta Adv Drug Deliv Rev 38 1999 41-58
4. D. Evain-Brion A. Malassine Human placenta as an endocrine organ Growth Horm IGF Res 13 Suppl A 2003 S34-S37
5. Q.J. Shi Z.M. Lei C.V. Rao J. Lin Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts Endocrinology 132 1993 1387-1395
6. L. Cronier B. Bastide J.C. Herve J. Deleze A. Malassine Gap junctional communication during human trophoblast differentiation: Influence of human chorionic gonadotropin Endocrinology 135 1994 402-408
7. J. Guibourdenche S. Roulier C. Rochette-Egly D. Evain-Brion High retinoid X receptor expression in JEG-3 choriocarcinoma cells: involvement in cell function modulation by retinoids J Cell Physiol 176 1998 595-601
8. A. Tarrade K. Schoonjans J. Guibourdenche J.M. Bidart M. Vidaud J. Auwerx et al. PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation Endocrinology 142 2001 4504-4514
9. E.D. Rosen B.M. Spiegelman PPAR{gamma}: A nuclear regulator of metabolism, differentiation, and cell growth J Biol Chem 2001
10. Y. Barak M.C. Nelson E.S. Ong Y.Z. Jones P. Ruiz-Lozano K.R. Chien et al. PPAR gamma is required for placental, cardiac, and adipose tissue development Mol Cell 4 1999 585-595
11. W.T. Schaiff M.G. Carlson S.D. Smith R. Levy D.M. Nelson Y. Sadovsky Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner J Clin Endocrinol Metab 85 2000 3874-3881
12. B.A. Janowski P.J. Willy T.R. Devi J.R. Falck D.J. Mangelsdorf An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha Nature 383 1996 728-731
13. J.M. Lehmann S.A. Kliewer L.B. Moore T.A. Smith-Oliver B.B. Oliver J.L. Su et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway J Biol Chem 272 1997 3137-3140
14. P.J. Willy K. Umesono E.S. Ong R.M. Evans R.A. Heyman D.J. Mangelsdorf LXR, a nuclear receptor that defines a distinct retinoid response pathway Genes Dev 9 1995 1033-1045
15. D.J. Peet S.D. Turley W. Ma B.A. Janowski J.M. Lobaccaro R.E. Hammer et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha Cell 93 1998 693-704
16. J.J. Repa S.D. Turley J.A. Lobaccaro J. Medina L. Li K. Lustig et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers Science 289 2000 1524-1529
17. J.J. Repa K.E. Berge C. Pomajzl J.A. Richardson H. Hobbs D.J. Mangelsdorf Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta J Biol Chem 277 2002 18793-18800
18. A. Venkateswaran B.A. Laffitte S.B. Joseph P.A. Mak D.C. Wilpitz P.A. Edwards et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha Proc Natl Acad Sci U S A 97 2000 12097-12102
19. J.J. Repa G. Liang J. Ou Y. Bashmakov J.M. Lobaccaro I. Shimomura et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Genes Dev 14 2000 2819-2830
20. G.E. Muscat B.L. Wagner J. Hou R.K. Tangirala E.D. Bischoff P. Rohde et al. Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors J Biol Chem 277 2002 40722-40728
21. K.R. Steffensen J.A. Gustafsson Putative metabolic effects of the liver X receptor (LXR) Diabetes 53 Suppl 1 2004 S36-S42
22. C.A. Hubel M.K. McLaughlin R.W. Evans B.A. Hauth C.J. Sims J.M. Roberts Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum Am J Obstet Gynecol 174 1996 975-982
23. J.M. Potter P.J. Nestel The hyperlipidemia of pregnancy in normal and complicated pregnancies Am J Obstet Gynecol 133 1979 165-170
24. W.E. Connor D.S. Lin Placental transfer of cholesterol-4-14C into rabbit and guinea pig fetus J Lipid Res 8 1967 558-564
25. D.S. Lin R.M. Pitkin W.E. Connor Placental transfer of cholesterol into the human fetus Am J Obstet Gynecol 128 1977 735-739
26. M. Murata H. Kodama K. Goto H. Hirano T. Tanaka Decreased very-low-density lipoprotein and low-density lipoprotein receptor messenger ribonucleic acid expression in placentas from preeclamptic pregnancies Am J Obstet Gynecol 175 1996 1551-1556
27. F.M. Campbell P.G. Bush J.H. Veerkamp A.K. Duttaroy Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placenta Placenta 19 1998 409-415
28. A.K. Duttaroy J. Taylor M.J. Gordon N. Hoggard F.M. Campbell Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells Biochem Biophys Res Commun 299 2002 432-437
29. A.K. Duttaroy D. Crozet J. Taylor M.J. Gordon Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: Effects of fatty acids Prostaglandins Leukot Essent Fatty Acids 68 2003 43-48
30. K.E. Schmid W.S. Davidson L. Myatt L.A. Woollett Transport of cholesterol across a BeWo cell monolayer: Implications for net transport of sterol from maternal to fetal circulation J Lipid Res 44 2003 1909-1918
31. C. Wadsack A. Hrzenjak A. Hammer B. Hirschmugl S. Levak-Frank G. Desoye et al. Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins Eur J Biochem 270 2003 451-462
32. K.T. Dalen S.M. Ulven K. Bamberg J.A. Gustafsson H.I. Nebb Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha J Biol Chem 278 2003 48283-48291
33. A.C. Rustan B. Halvorsen A.C. Huggett T. Ranheim C.A. Drevon Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells Arterioscler Thromb Vasc Biol 17 1997 2140-2149
34. A. Chaan N.M. Laird P. Slasor Tutorial in biostatistics; using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data Stat Med 16 1997 2349-2380
35. J.R. Schultz H. Tu A. Luk J.J. Repa J.C. Medina L. Li et al. Role of LXRs in control of lipogenesis Genes Dev 14 2000 2831-2838
36. K.A. Tobin S.M. Ulven G.U. Schuster H.H. Steineger S.M. Andresen J.A. Gustafsson et al. LXRs as insulin mediating factors in fatty acid and cholesterol biosynthesis J Biol Chem 2002
37. L.K. Juvet S.M. Andresen G.U. Schuster K.T. Dalen K.A. Tobin K. Hollung et al. On the role of liver x receptors in lipid accumulation in adipocytes Mol Endocrinol 17 2003 172-182
38. L. Pavan A. Hermouet V. Tsatsaris P. Therond T. Sawamura D. Evain-Brion et al. Lipids from oxidized-LDL modulate human trophoblast invasion: involvement of LXR nuclear receptors Endocrinology 2004
39. R.A. Coleman E.B. Haynes Synthesis and release of fatty-acids by human trophoblast cells in culture J Lipid Res 28 1987 1335-1341
40. R.E. Wilentz L.A. Witters E.S. Pizer Lipogenic enzymes fatty acid synthase and acetyl-coenzyme A carboxylase are coexpressed with sterol regulatory element binding protein and Ki-67 in fetal tissues Pediatr Dev Pathol 3 2000 525-531
41. T. Clausen S. Djurovic T. Henriksen Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia BJOG 108 2001 1081-1087
42. E. Gratacos Lipid-mediated endothelial dysfunction: A common factor to preeclampsia and chronic vascular disease Eur J Obstet Gynecol Reprod Biol 92 2000 63-66
43. C. Wadsack A. Hammer S. Levak-Frank G. Desoye K.F. Kozarsky B. Hirschmugl et al. Selective cholesteryl ester uptake from high density lipoprotein by human first trimester and term villous trophoblast cells Placenta 24 2003 131-143
44. A. Chawla W.A. Boisvert C. Lee B.A. Laffitte Y. Barak S.B. Joseph et al. A PPARgamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Mol Cell 7 2001 161-171
45. G. Cao Y. Liang C.L. Broderick B.A. Oldham T.P. Beyer R.J. Schmidt et al. Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis J Biol Chem 278 2003 1131-1136
46. T.M. Stulnig U. Oppermann K.R. Steffensen G.U. Schuster J.A. Gustafsson Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity Diabetes 51 2002 2426-2433
47. T.M. Stulnig K.R. Steffensen H. Gao M. Reimers K. Dahlman-Wright G.U. Schuster et al. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue Mol Pharmacol 62 2002 1299-1305