Capillary electrophoretic characterization of PEGylated human parathyroid hormone with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Analytical Biochemistry

Volumn 331, Issue 2, 2004, Pages 322-328

  Na, Dong Hee ^a   Lee, Kang Choon ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Capillary electrophoresis; Human parathyroid hormone; Matrix assisted laser desorption ionization time of flight mass spectrometry; PEGylation

Indexed keywords

CAPILLARY ELECTROPHORESIS; DESORPTION; INDUCTIVELY COUPLED PLASMA; ISOMERS; MOLAR RATIO;

CAPILLARY ELECTROPHORETIC METHODS; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; PARATHYROID HORMONES; PEGYLATION; SAMPLE CONSUMPTION; SEPARATION CAPACITY; SIMULTANEOUS ANALYSIS; THERAPEUTIC PEPTIDES;

MASS SPECTROMETRY;

MACROGOL; PARATHYROID HORMONE[1-34]; PROTEINASE;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG ISOLATION; HUMAN; ISOMER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PH MEASUREMENT; PHASE SEPARATION; PRIORITY JOURNAL;

EID: 3242684181     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2004.04.036     Document Type: Article

References (27)

1. Sato M., Zeng G.Q., Turner C.H. Biosynthetic human parathyroid hormone (1-34) effects on bone quality in aged ovariectomized rats. Endocrinology. 10:1997;4330-4337
2. Jerome C.P., Burr D.B., Van Bibber T., Hock J.M., Brommage R. Treatment with human parathyroid hormone (1-34) for 18 months increases cancellous bone volume and improves trabecular architecture in ovariectomized cynomolgus monkeys (Macaca fascicularis). Bone. 28:2001;150-159
3. Rubin M.R., Cosman F., Linday R., Bilezikian J.P. The anabolic effects of parathyroid hormone. Osteoporos. Int. 13:2002;267-277
4. Berg C., Neumeyer K., Kirkpatrick P. Teriparatide. Nat. Rev. Drug Discov. 2:2003;257-258
5. Leone-Bay A., Sato M., Paton D., Hunt A.H., Sarubbi D., Carozza M., Chou J., McDonough J., Baughman R.A. Oral delivery of biologically active parathyroid hormone. Pharm. Res. 18:2001;964-970
6. Codrons V., Vanderbist F., Verbeeck R.K., Arras M., Lison D., Preat V., Vanbever R. Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats. J. Pharm. Sci. 92:2003;938-950
7. Chang S.L., Hofmann G.A., Zhang L., Deftos L.J., Banga A.K. The effect of electroporation on iontophoretic transdermal delivery of calcium regulating hormones. J. Control. Rel. 66:2000;127-133
8. P.P. DeLuca, B.A. Dani, Skeletal effects of parathyroid hormone (1-34) in ovariectomized rats with or without concurrent administration of salmon calcitonin, AAPS PharmSci. 3 (2001) article 27
9. Lee K.C., Tak K.K., Park M.O., Lee J.T., Woo B.H., Yoo S.D., Lee H.S., DeLuca P.P. Preparation and characterization of polyethylene glycol modified salmon calcitonins. Pharm. Dev. Tech. 4:1999;269-275
10. Na D.H., Youn Y.S., Park E.J., Lee J.M., Cho O.R., Lee K.R., Lee S.D., Yoo S.D., DeLuca P.P., Lee K.C. Stability of PEGylated salmon calcitonin in nasal mucosa. J. Pharm. Sci. 93:2004;256-261
11. Lee K.C., Park M.O., Na D.H., Youn Y.S., Lee S.D., Yoo S.D., Lee H.S., DeLuca P.P. Intranasal delivery of PEGylated salmon calcitonins: hypocalcemic effects in rats. Calcif. Tissue Int. 73:2003;545-549
12. Roberts M.J., Bentley M.D., Harris J.M. Chemistry for peptide and protein PEGylation. Adv. Drug Deliv. Rev. 54:2002;459-476
13. Monkarsh S.P., Ma Y., Aglione A., Bailon P., Ciolek D., DeBarbieri B., Graves M.C., Hollfelder K., Michel H., Palleroni A., Porter J.E., Russoman E., Roy S., Pan Y.C. Positional isomers of monopegylated interferon alpha-2a: isolation, characterization, and biological activity. Anal. Biochem. 247:1997;434-440
14. Bullock J., Chowdhury S., Johnston D. Characterization of poly(ethylene glycol)-modified superoxide dismutase: comparison of capillary electrophoresis and matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 68:1996;3258-3264
15. Bullock J., Chowdhury S., Severdia A., Sweeney J.D., Johnston D., Pachla L. Comparison of results of various methods used to determine the extent of modification of methoxy polyethylene glycol 5000-modified bovine cupri-zinc superoxide dismutase. Anal. Biochem. 254:1997;254-262
16. Na D.H., Youn Y.S., Lee K.C. Optimization of the PEGylation process of a peptide by monitoring with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 17:2003;2241-2244
17. Na D.H., Park E.J., Youn Y.S., Moon B.W., Jo Y.W., Lee S.H., Kim W.B., Sohn Y., Lee K.C. Sodium dodecyl sulfate-capillary gel electrophoresis of polyethylene glycolylated interferon alpha. Electrophoresis. 25:2004;476-479
18. Roberts M.J., Harris J.M. Attachment of degradable poly(ethylene glycol) to proteins has the potential to increase therapeutic efficacy. J. Pharm. Sci. 87:1998;1440-1445
19. Li W., Zhong Y., Lin B., Su Z. Characterization of polyethylene glycol-modified proteins by semi-aqueous capillary electrophoresis. J. Chromatogr. A. 905:2001;299-307
20. Na D.H., Park M.O., Choi S.Y., Kim Y.S., Lee S.S., Yoo S.D., Lee H.S., Lee K.C. Identification of the modifying sites of mono-PEGylated salmon calcitonins by capillary electrophoresis and MALDI-TOF mass spectrometry. J. Chromatogr. B. 754:2001;259-263
21. D.H. Na, S.B. Murty, K.C. Lee, B.C. Thanoo, P.P. DeLuca, Preparation and stability of poly (ethylene glycol) (PEG)ylated octreotide for application to microsphere delivery, AAPS PharmSci. Tech. 4 (2003) article 72
22. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:1985;76-85
23. Lee K.C., Moon S.C., Park M.O., Lee J.T., Na D.H., Yoo S.D., Lee H.S., DeLuca P.P. Isolation, characterization, and stability of positional isomers of mono-PEGylated salmon calcitonins. Pharm. Res. 16:1999;818-823
24. Offord R.E. Electrophoretic mobilities of peptides on paper and their use in the determination of amide groups. Nature. 211:1966;591-593
25. Yang T., Horejsh D.R., Mahan K.J., Zaluzec E.J., Watson T.J., Gage D.A. Mapping cross-linking sites in modified proteins with mass spectrometry: an application to cross-linked hemoglobins. Anal. Biochem. 242:1996;55-63
26. Inouye S., Nakamura M. Identification of biotinylated lysine residues in the photoprotein aequorin by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry peptide mapping after lysine-specific endopeptidase digestion. Anal. Biochem. 316:2003;216-222
27. Gusev A.I., Wilkinson W.R., Proctor A., Hercules D.M. Improvement of signal reproducibility and matrix/comatrix effects in MALDI analysis. Anal. Chem. 67:1995;1034-1041