2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) - Induced accumulation of biliverdin and hepatic peliosis in rats

Toxicological Sciences

Volumn 71, Issue 1, 2003, Pages 112-123

  Niittynen, Marjo ^a   Tuomisto, Jouni T ^a   Auriola, Seppo ^b   Pohjanvirta, Raimo ^a,c,d   Syrjälä, Paula ^c   Simanainen, Ulla ^a   Viluksela, Matti ^a   Tuomisto, Jouko ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c NATL VET AND FOOD RES INSTITUTE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Accumulation; Bilirubin; Biliverdin; Hepatotoxicity; Peliosis; Porphyrin metabolism; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BILIVERDIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; CHEMOSENSITIVITY; CONTROLLED STUDY; CROSS BREEDING; FEMALE; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; LIVER SINUSOID; LIVER TOXICITY; MALE; MASS SPECTROMETRY; NONHUMAN; PELIOSIS HEPATIS; POLLUTANT; PROTEIN DOMAIN; RAT; RAT STRAIN; REVIEW; THIN LAYER CHROMATOGRAPHY; VEIN DILATATION;

ANIMALIA;

EID: 0037256826     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/71.1.112     Document Type: Review

References (35)

1. Arnold, D. L., Moodie, C. A., Charbonneau, S. M., Grice, H. C., McGuire, P. F., Bryce, F. R., Collins, B. T., Zawidzka, Z. Z., Krewski, D. R., Nera, E. A., and Munro, I. C. (1985). Long-term toxicity of hexachlorobenzene in the rat and the effect of dietary vitamin A. Food Chem. Toxicol. 23, 779-793.
2. Bonkovsky, H. L., Wood, S. G., Howell, S. K., Sinclair, P. R., Lincoln, B., Healey, J. F., and Sinclair, J. F. (1986). High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials. Anal. Biochem. 155, 56-64.
3. Burger, R. A., and Marcuse, P. M. (1952). Peliosis hepatis. Report of a case. Am. J. Clin. Pathol. 22, 569-573.
4. Cardenas-Vazquez, R., Yokosuka, O., and Billing, B. H. (1986). Enzymic oxidation of unconjugated bilirubin by rat liver. Biochem. J. 236, 625-633.
5. Choe, S. Y., and Yang, K. H. (1983). Effect of butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) on carbon tetrachloride and TCDD hepatotoxicity. Korean Biochem. J. 16, 315-321.
6. Cohen, A. N., Kapitulnik, J., Ostrow, J. D., and Webster, C. C. (1986). Effect of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and phototherapy on bilirubin metabolism in the jaundiced Gunn rat. Hepatology 6, 490-494.
7. Dudnik, L. B., and Khrapova, N. G. (1998). Characterization of bilirubin inhibitory properties in free radical oxidation reactions. Membr. Cell Biol. 12, 233-240.
8. Elbirt, K. K., and Bonkovsky, H. L. (1999). Heme oxygenase: Recent advances in understanding its regulation and role. Proc. Assoc. Am. Physicians 111, 438-447.
9. Enan, E., and Matsumura, F. (1995). Evidence for a second pathway in the action mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Significance of Ah-receptor mediated activation of protein kinase under cell-free conditions. Biochem. Pharmacol. 49, 249-261.
10. Galbraith, R. (1999). Heme oxygenase: Who needs it? Proc. Soc. Exp. Biol. Med. 222, 299-305.
11. Hamilton, F. T., and Lubitz, J. M. (1952). Peliosis hepatis: A report of 3 cases with discussion of pathogenesis. Arch. Pathol. 54, 564-572.
12. Huang, T. J., Trakshel, G. M., and Maines, M. D. (1989). Microheterogeneity of biliverdin reductase in rat liver and spleen: Selective suppression of enzyme variants in liver by bromobenzene. Arch. Biochem. Biophys. 274, 617-625.
13. Ivens, I. A., Löser, E., Rinke, M., Schmidt, U., and Mohr, U. (1993). Subchronic toxicity of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats. Toxicology 83, 181-201.
14. Lemberg, R., and Legge, J. W. (1949). Hematin Compounds and Bile Pigments. Interscience Publishers, New York.
15. Maines, M. D. (1999). Overview of heme degradation pathway. In Current Protocols in Toxicology (M. D. Maines, L. G. Costa, D. J. Reed, S. Sassa, and I. G. Sipes, Eds.), pp. 9.1.1-9.1.5. John Wiley & Sons, Inc., New York.
16. Minetti, M., Mallozzi, C., Di Stasi, A. M., and Pietraforte, D. (1998). Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma. Arch. Biochem. Biophys. 352, 165-174.
17. Mitchell, D. Y., Madhu, C., and Klaassen, C. D. (1990). Hepatotoxicants elevate serum bilirubin by increasing formation not decreasing elimination of bilirubin. Tox. Sci. 10(Suppl.), 61 (Abstract).
18. Murray, R. K. (1988). Porphyrins and bile pigments. In Harper's Biochemistry, 21st ed. (R. K. Murray, D. K. Granner, P. A. Mayes, and V. W. Rodwell, Eds.), pp. 319-334. Appleton & Lange, Norwalk, CT.
19. Onaya, H., Itai, Y., Yoshioka, H., Doy, M., and Mitsumori, F. (2000). Peliosis hepatis and neoplastic/dysplastic lesions in aged male Long-Evans Cinnamon rats: MR imaging with pathologic correlation. Magn. Reson. Imaging 18, 143-150.
20. Pohjanvirta, R. (1990). TCDD resistance is inherited as an autosomal dominant trait in the rat. Toxicol. Lett. 50, 49-56.
21. Pohjanvirta, R., Kulju, T., Morselt, A. F., Tuominen, R., Juvonen, R., Rozman, K., Männistö, P., Collan, Y., Sainio, E.-L., and Tuomisto, J. (1989). Target tissue morphology and serum biochemistry following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in a TCDD-susceptible and a TCDD-resistant rat strain. Fundam. Appl. Toxicol. 12, 698-712.
22. Pohjanvirta, R., and Tuomisto, J. (1994). Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms and animal models. Pharmacol. Rev. 46, 483-549.
23. Pohjanvirta, R., Wong, J. M., Li, W., Harper, P. A., Tuomisto, J., and Okey, A. B. (1998). Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol. Pharmacol. 54, 86-93.
24. Ryter, S. W., and Tyrrell, R. M. (2000). The heme synthesis and degradation pathways: Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radical Biol. Med. 28, 289-309.
25. Salim, M., Brown-Kipphut, B. A., and Maines, M. D. (2001). Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation. J. Biol. Chem. 276, 10929-10934.
26. Sassa, S., and Maines, M. D. (2001). Heme synthesis pathway. In Current Protocols in Toxicology (M. D. Maines, L. G. Costa, D. J. Reed, S. Sassa, and I. G. Sipes, Eds.), pp. 8.0.1-8.0.3. John Wiley & Sons, Inc., New York.
27. Simanainen, U., Tuomisto, J. T., Tuomisto, J., and Viluksela, M. (2002). Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains. Toxicol. Appl. Pharmacol. 181, 38-47.
28. Smith, A. G., Carthew, P., Francis, J. E., Cabral, J. R., and Manson, M. M. (1993). Enhancement by iron of hepatic neoplasia in rats caused by hexachlorobenzene. Carcinogenesis 14, 1381-1387.
29. Smith, A. G., Clothier, B., Carthew, P., Childs, N. L., Sinclair, P. R., Nebert, D. W., and Dalton, T. P. (2001). Protection of the Cypla2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 173, 89-98.
30. Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., and Ames, B. N. (1987). Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046.
31. Stonard, M. D., Poli, G., and De Matteis, F. (1998). Stimulation of liver heme oxygenase in hexachlorobenzene-induced hepatic porphyria. Arch. Toxicol. 72, 355-361.
32. Tuomisto, J. T., Viluksela, M., Pohjanvirta, R., and Tuomisto, J. (1999). The Ah receptor and a novel gene determine acute toxic responses to TCDD: Segregation of the resistant alleles to different rat lines. Toxicol. Appl. Pharmacol. 155, 71-81.
33. Unkila, M., Pohjanvirta, R., MacDonald, E., Tuomisto, J. T., and Tuomisto, J. (1994). Dose response and time course of alterations in tryptophan metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the most TCDD-susceptible and the most TCDD-resistant rat strain: Relationship with TCDD lethality. Toxicol. Appl. Pharmacol. 128, 280-292.
34. Yang, K. H., Yoo, B. S., and Choe, S. Y. (1983). Effects of halogenated dibenzo-p-dioxins on plasma disappearance and biliary excretion of ouabain in rats. Toxicol. Lett. 15, 259-264.
35. Yokosuka, O., and Billing, B. (1987). Enzymatic oxidation of bilirubin by intestinal mucosa. Biochim. Biophys. Acta 923, 268-274