The AH receptor and a novel gene determine acute toxic responses to TCDD: Segregation of the resistant alleles to different rat lines

Toxicology and Applied Pharmacology

Volumn 155, Issue 1, 1999, Pages 71-81

  Tuomisto, Jouni T ^a   Viluksela, Matti ^a   Pohjanvirta, Raimo ^a   Tuomisto, Jouko ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

AHR; Aryl hydrocarbon receptor; Bilirubin; CYP1A1; EROD; Lethality; Rats; Resistance genes; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BILIRUBIN; CYTOCHROME P450; ETHOXYRESORUFIN DEETHYLASE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; ENZYME INDUCTION; GENE DOSAGE; GENE SEGREGATION; GENETIC RESISTANCE; GENETIC SELECTION; GENOTYPE; LETHALITY; NONHUMAN; RAT;

ANIMALIA; RATTUS NORVEGICUS; RODENTIA;

EID: 0033062111     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8564     Document Type: Article

References (36)

1. Alaluusua S., Lukinmaa P-L., Pohjanvirta R., Unkila M., Tuomisto J. Exposure to 2,3,7,8-tetrachlorodibenzo-p. Toxicology. 81:1993;1-13.
2. Alaluusua S., Lukinmaa P-L., Vartiainen T., Partanen M., Torppa J., Tuomisto J. Polychlorinated dibenzo-p. Environ. Toxicol. Pharmacol. 1:1996;193-197.
3. Beatty P. W., Vaughn W. K., Neal R. A. Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 45:1978;513-519.
4. Birnbaum L. S., McDonald M. M., Blair P. C., Clark A. M., Harris M. W. Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p. Fundam. Appl. Toxicol. 15:1990;186-200.
5. Bradford M. M. A rapid and sensitive method for quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Denison M. S., Winters M. G., Rogers W. J., Phelan D. Bilirubin and biliverdin are endogenous activators of the Ah receptor signal transduction pathway. Toxicol. Sci. 42:1998.
7. Elferink C. J., Whitlock J. P. Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor. Receptor. 4:1994;157-173.
8. Lab. Anim. 30:1996;193-208.
9. Fernandez-Salguero P., Pineau T., Hilbert D., McPhail T., Lee S. S. T., Kimura S., Nebert D. W., Rudikoff S., Ward J. M., Gonzales F. J. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science. 268:1995;722-726.
10. Fernandez-Salguero P. M., Hilbert D. M., Rudikoff S., Ward J. M., Gonzales F. J. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 140:1996;173-179.
11. Huuskonen H., Unkila M., Pohjanvirta R., Tuomisto J. Developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 124:1994;174-180.
12. Jain S., Dolwick K. M., Schmidt J. V., Bradfield C. A. Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. J. Biol. Chem. 269:1994;31518-31524.
13. Kennedy S. W., Jones S. P. Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorecence plate reader. Anal. Biochem. 222:1994;217-223.
14. Knutson J. C., Poland A. Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p. Cell. 30:1982;225-234.
15. Kohn M. C., Lucier G. W., Clark G. C., Sewall C., Tritscher A. M., Portier C. J. A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicol. Appl. Pharmacol. 120:1993;138-154.
16. Litchfield J. T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-113.
17. Okey A. B., Riddick D. S., Harper P. A. The Ah receptor: Mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Lett. 70:1994;1-22.
18. Pohjanvirta R. TCDD resistance is inherited as an autosomal dominant trait in the rat. Toxicol. Lett. 50:1990;49-56.
19. Pohjanvirta R., Juvonen R., Kärenlampi S., Raunio H., Tuomisto J. Hepatic Ah-receptor levels and the effect of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 92:1988;131-140.
20. Pohjanvirta R., Kulju T., Morselt A. F. W., Tuominen R., Juvonen R., Rozman K., Männistö P., Collan Y., Sainio E.-L., Tuomisto J. Target tissue morphology and serum biochemistry following 2,3,7,8-tetrachlorodibenzo-p. Fundam. Appl. Toxicol. 12:1989;698-712.
21. Pohjanvirta R., Tuomisto J. Letter to the editor. Toxicol. Appl. Pharmacol. 105:1990;508-509.
22. Pohjanvirta R., Tuomisto J. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p. Pharmacol. Rev. 46:1994;483-549.
23. Pohjanvirta R., Tuomisto J., Vartiainen T., Rozman K. Han/Wistar rats are exceptionally resistant to TCDD. I. Pharmacol. Toxicol. 60:1987;145-150.
24. Pohjanvirta R., Unkila M., Lindén J., Tuomisto J. T., Tuomisto J. Toxic equivalency factors do not predict the acute toxicities of dioxins in rats. Eur. J. Pharmacol. 293:1995;341-353.
25. Pohjanvirta R., Unkila M., Tuomisto J. Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo-ppp. Pharmacol. Toxicol. 73:1993;52-56.
26. Pohjanvirta R., Viluksela M., Tuomisto J. T., Unkila M., Karasinska J., Franc M.-A., Holowenko M., Giannone J. V., Harper P. A., Tuomisto J., Okey A. B. Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains. Toxicol. Appl. Pharmacol. 153:1998b;000-000.
27. Pohjanvirta R., Wong J. M. Y., Li W., Harper P. A., Tuomisto J., Okey A. B. Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7, 8-tetrachlorodibenzo-p. Mol. Pharmacol. 54:1998a;86-93.
28. Poland A., Glover E. Genetic expression of aryl hydrocarbon hydroxylase by 2,3,7,8-tetrachlorodibenzo-p. Mol. Pharmacol. 11:1975;389-398.
29. Poland A., Palen D., Glover E. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 46:1994;915-921.
30. Tuomisto J., Pohjanvirta R. The Long-Evans rat: A prototype of an extremely TCDD-susceptible strain variant. Pharmacol. Toxicol. 60:1987;72.
31. Tuomisto J. T., Pohjanvirta T., Unkila M., Tuomisto J. 2,3,7,8-Tetrachlorodibenzo-p. Eur. J. Pharmacol. 293:1995;309-317.
32. Tuomisto J. T., Pohjanvirta R., Unkila M., Tuomisto J. TCDD-induced anorexia and wasting syndrome in rats: Effects of diet-induced obesity and nutrition. Pharmacol. Biochem. Behav. 1998.
33. Unkila M., Pohjanvirta R., MacDonald E., Tuomisto J. T., Tuomisto J. Dose response and time course of alterations in tryptophan metabolism by 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 128:1994;280-292.
34. Viluksela M., Simanainen U., Tuomisto J. T., Pohjanvirta R., Harper P. A., Okey A. B., Tuomisto J. Characterization of the deviant structure-activity relationship for chlorinated dibenzo-p. Organohalogen Compd. 38:1998;287-290.
35. Walters M., Gerarde H. An ultramicromethod for the determination of conjugated and total bilirubin in serum or plasma. Microchem. J. 15:1970;231-243.
36. Whitelaw M. L., Gustafsson J.-Å., Poellinger L. Identification of transactivation and repression function of the dioxin receptor and its basic helix-loop-helix/PAS partner factor ARNT: Inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14:1994;8343-8355.