Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis

Current Allergy and Asthma Reports

Volumn 5, Issue 3, 2005, Pages 182-185

  Broide, David H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ALPHA INTERFERON; AMB A I IMMUNOSTIMULATORY OLIGODEOXYNUCLEOTIDE CONJUGATE; APC; BETA INTERFERON; COLLAGEN TYPE 3; COLLAGEN TYPE 5; CORTICOSTEROID; CYTOKINE; DEXAMETHASONE; DNA VACCINE; GAMMA INTERFERON; IMMUNOSTIMULATORY SEQUENCE DNA; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5 ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 9; METHACHOLINE; MONOKINE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; PHYTOHEMAGGLUTININ; PLACEBO; STREPTOKINASE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ALLERGENICITY; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ANTIVIRAL ACTIVITY; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; CPG ISLAND; DNA CONTENT; DNA SEQUENCE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG SAFETY; EOSINOPHILIA; FIBROSIS; FLUORESCENCE; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VIVO STUDY; INNATE IMMUNITY; LUNG LAVAGE; MONOTHERAPY; MYOFIBROBLAST; NASAL BIOPSY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLLEN ALLERGY; PROTEIN EXPRESSION; RAGWEED; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; SINGLE DRUG DOSE; SYMPTOMATOLOGY; TH1 CELL; TH2 CELL; VIRUS REPLICATION;

EID: 20044378127     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-005-0035-7     Document Type: Review

References (22)

1. Yamamoto S, Yamamoto T, Kataoka T, et al.: Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer cell activity. J Immunol 1992, 148:4072-4076.
2. Krieg AM: CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002, 20:709-760.
3. Spiegelberg HL, Horner AA, Takabayashi K, Raz E: Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr Opin Allergy Clin Immunol 2002, 2:547-551.
4. Hayashi T, Beck L, Rossetto C, et al.: Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest 2004, 114:270-279.
5. Kline JN, Krieg AM, Waldschmidt TJ, et al.: CpG oligodeoxynucleotides do not require Th1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. J Allergy Clin Immunol 1999, 104:1258-1264.
6. Broide D, Schwarze J, Tighe H, et al.: Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 1998, 161:7054-7062.
7. Ikeda RK, Nayar J, Cho JY, et al.: Resolution of airway inflammation following OVA inhalation: comparison of ISS DNA and corticosteroids. Am J Resp Cell Mol Biol 2003, 28:655-663.
8. Cho J, Miller M, Baek K, et al.: Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion. J Allergy Clin Immunol 2001, 108:697-702.
9. Cho JY, Miller M, Baek KJ, et al.: Immunostimulatory DNA inhibits TGF-beta expression and airway remodeling. Am J Resp Cell Mol Biol 2004, 30:651-661.
10. Cho JY, Miller M, Baek KJ, et al.: Immunostimulatory DNA reverses established allergen induced airway remodeling. J Immunol 2004, 30:7556-7664.
11. Cho JY, Miller M, Baek KJ, et al.: Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 2004, 113:551-560.
12. Flood-Page P, Menzies-Gow A, Phipps S, et al.: Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003, 112:1029-1036.
13. Fanucchi MV, Schelegle ES, Baker GL, et al.: Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys. Am J Respir Crit Care Med 2004, 170:1153-1157.
14. Bohle B, Jahn-Schmid B, Maurer D, et al.: Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18, and IFN-gamma production in cells from allergic individuals and inhibits IgE synthesis in vitro. Eur J Immunol 1999, 29:2344-2353.
15. Shirota H, Sano K, Hirasawa K, et al.: Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG tagged antigen by dendritic cells. J Immunol 2001, 167:66-74.
16. Tighe H, Takabayashi K, Schwartz D, et al.: Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 2000, 106:124-134.
17. Santeliz JV, Van Nest G, Traquina P, et al.: Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J Allergy Clin Immunol 2002, 109:455-462.
18. Marshall JD, Abtahi S, Eiden J, et al.: Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes Th1 cytokine expression while downregulating Th2 cytokine expression in PBMCs from human patients with ragweed allergy. J Allergy Clin Immunol 2001, 108:191-197.
19. Simons FE, Shikishima Y, Van Nest G, et al.: Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J Allergy Clin Immunol 2004, 113:1144-1151.
20. Creticos PS, Eiden JJ, Balcer SL, et al.: Immunostimulatory oligodeoxynucleotides conjugated to Amb a 1: safety, skin test reactivity, and basophil histamine release. J Allergy Clin Immunol 2000, 105:S70.
21. Creticos PS, Eiden JJ, Broide DH, et al.: Immunotherapy with immunostimulatory oligonucleotides linked to purified ragweed Amb a 1 allergen: effects on antibody production, nasal allergen provocation, and ragweed seasonal rhinitis. J Allergy Clin Immunol 2002, 109:743.
22. Tulic MK, Fiset PO, Christodoulopoulos P, et al.: Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. J Allergy Clin Immunol 2004, 13:235-241.