Prevention of type 1 diabetes with major histocompatibility complex-compatible and nonmarrow ablative hematopoietic stem cell transplants

Diabetes

Volumn 54, Issue 6, 2005, Pages 1770-1779

  Beilhack, Georg F ^a   Landa, Rosa R ^a   Masek, Marilyn A ^a   Shizuru, Judith A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL DESTRUCTION; CONTROLLED STUDY; GENE DOSAGE; GENETIC SUSCEPTIBILITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PATHOGENESIS; PRIORITY JOURNAL; RECIPIENT; T LYMPHOCYTE ACTIVATION;

ANIMALS; B-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED NOD; PHENOTYPE; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 20044377064     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.6.1770     Document Type: Article

References (54)

1. Serreze D, Leiter E: Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice. In Molecular Pathology of Type 1 Diabetes mellitus. von Herrath MG, Ed. Basel, Switzerland, Karger, 2001, p. 31-67
2. Tisch R, McDevitt H: Insulin-dependent diabetes mellitus. Cell 85:291-297, 1996
3. Acha-Orbea H, McDevitt HO: The first external domain of the nonobese diabetic mouse class II I-A β chain is unique. Proc Natl Acad Sci U S A 84:2435-2439, 1987
4. Hattori M, Buse JB, Jackson RA, Glimcher L, Dorf ME, Minami M, Makino S, Moriwaki K, Kuzuya H, Imura H, et al.: The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 231:733-735, 1986
5. Chao CC, Sytwu HK, Chen EL, Toma J, McDevitt HO: The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire. Proc Natl Acad Sci U S A 96:9299-9304, 1999
6. Nishimoto H, Kikutani H, Yamamura K, Kishimoto T: Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 328:432-434, 1987
7. Slattery RM, Kjer-Nielsen L, Allison J, Charlton B, Mandel TE, Miller JF: Prevention of diabetes in non-obese diabetic I-Ak transgenic mice. Nature 345:724-726, 1990
8. Miyazaki T, Uno M, Uehira M, Kikutani H, Kishimoto T, Kimoto M, Nishimoto H, Miyazaki J, Yamamura K: Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice. Nature 345:722-724, 1990
9. Lund T, O'Reilly L, Hutchings P, Kanagawa O, Simpson E, Gravely R, Chandler P, Dyson J, Picard JK, Edwards A, et al.: Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain. Nature 345:727-729, 1990
10. Wicker LS, Appel MC, Dotta F, Pressey A, Miller BJ, DeLarato NH, Fischer PA, Boltz RC Jr, Peterson LB: Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide induced diabetes. J Exp Med 176:67-77, 1992
11. Ikehara S, Ohtsuki H, Good RA, Asamoto H, Nakamura T, Sekita K, Muso E, Tochino Y, Ida T, Kuzuya H, et al.: Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation. Proc Natl Acad Sci U S A 82:7743-7747, 1985
12. Li H, Kaufman CL, Ildstad ST: Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice. Surgery 118:192-197 [discussion 197-198], 1995
13. LaFace DM, Peck AB: Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 38:894-901, 1989
14. Beilhack GF, Scheffold YC, Weissman IL, Taylor C, Jerabek L, Burge MJ, Masek MA, Shizuru JA: Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice. Diabetes 52:59-68, 2003
15. Parish NM, Chandler P, Quartey-Papafio R, Simpson E, Cooke A: The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes. Eur J Immunol 23:2667-2675, 1993
16. Slattery RM, Miller JF, Heath WR, Charlton B: Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes. Proc Natl Acad Sci U S A 90:10808-10810, 1993
17. Tian C, Bagley J, Cretin N, Seth N, Wucherpfennig KW, Iacomini J: Prevention of type 1 diabetes by gene therapy. J Clin Invest 114:969-978, 2004
18. Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL: Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 95:2175-2182, 2000
19. Ikehara S: Treatment of autoimmune diseases by hematopoietic stem cell transplantation. Exp Hematol 29:661-669, 2001
20. Burt RK, Slavin S, Burns WH, Marmont AM: Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood 99:768-784, 2002
21. van Bekkum DW: Experimental basis of hematopoietic stem cell transplantation for treatment of autoimmune diseases. J Leukoc Biol 72:609-620, 2002
22. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58-62, 1988
23. Randall TD, Lund FE, Howard MC, Weissman IL: Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood 87:4057-4067, 1996
24. Shizuru JA, Jerabek L, Edwards CT, Weissman IL: Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment. Biol Blood Marrow Transplant 2:3-14, 1996
25. Kitamura D, Roes J, Kuhn R, Rajewsky K: A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423-426, 1991
26. 2-microglobulin. J Immunol 160:1472-1478, 1998
27. Serreze DV, Prochazka M, Reifsnyder PC, Bridgett MM, Leiter EH: Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J Exp Med 180:1553-1558, 1994
28. Prochazka M, Serreze DV, Frankel WN, Leiter EH: NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice. Diabetes 41:98-106, 1992
29. Naggert JK, Mu JL, Frankel W, Bailey DW, Paigen B: Genomic analysis of the C57BL/KS mouse strain. Mamm Genome 6:131-133, 1995
30. Serreze DV, Gaedeke JW, Leiter EH: Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C. Proc Natl Acad Sci U S A 90:9625-9629, 1993
31. Makino S, Hayashi Y, Muraoka Y, Tochino Y: Breeding of the NON mouse and its genetic characteristics. In Current Concepts of a New Animal Model: The NON Mouse. Sakamoto N, Hotta N, Uchida K, Eds. Tokyo, Elsevier Science Publishers, 1992, p. 4-10
32. Wicker LS, Todd JA, Peterson LB: Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 13:179-200, 1995
33. Wu T, Levay-Young B, Heuss N, Sozen H, Kirchhof N, Sutherland DE, Hering B, Guo Z: Inducing tolerance to MHC-matched allogeneic islet grafts in diabetic NOD mice by simultaneous islet and bone marrow transplantation under nonirradiative and nonmyeloablative conditioning therapy. Transplantation 74:22-27, 2002
34. Steptoe RJ, Stankovic S, Lopaticki S, Jones LK, Harrison LC, Morahan G: Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation. J Autoimmun 22:131-138, 2004
35. Clare-Salzler M: The immunopathogenic roles of antigen presenting cells in the NOD mouse. In NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer and Other Diseases. Leiter EH, Atkinson MA, Eds. Austin, TX, R.G. Landes, 1998, p. 101-119
36. Kataoka S, Satoh J, Fujiya H, Toyota T, Suzuki R, Itoh K, Kumagai K: Immunologic aspects of the nonobese diabetic (NOD) mouse: abnormalities of cellular immunity. Diabetes 32:247-253, 1983
37. Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL: Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18:41-51, 2003
38. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431-440, 2000
39. +-like thymocytes in the NOD mouse. Eur J Immunol 26:2989-2998, 1996
40. +CD4-CD8-(NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J Exp Med 187:1047-1056, 1998
41. Shizuru JA, Weissman IL, Kernoff R, Masek M, Scheffold YC: Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Proc Natl Acad Sci U S A 97:9555-9560, 2000
42. Clare-Salzler MJ, Brooks J, Chai A, Van Herle K, Anderson C: Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer. J Clin Invest 90:741-748, 1992
43. Feili-Hariri M, Falkner DH, Morel PA: Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur J Immunol 32:2021-2030, 2002
44. Steptoe RJ, Ritchie JM, Harrison LC: Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. J Clin Invest 111:1357-1363, 2003
45. Serreze DV, Chapman HD, Varnum DS, Hanson MS, Reifsnyder PC, Richard SD, Fleming SA, Leiter EH, Shultz LD: B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med 184:2049-2053, 1996
46. Akashi T, Nagafuchi S, Anzai K, Kondo S, Kitamura D, Wakana S, Ono J, Kikuchi M, Niho Y, Watanabe T: Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice. Int Immunol 9:1159-1164, 1997
47. Noorchashm H, Noorchashm N, Kern J, Rostami SY, Barker CF, Naji A: B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 46:941-946, 1997
48. Wu AJ, Hua H, Munson SH, McDevitt HO: Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc Natl Acad Sci U S A 99:12287-12292, 2002
49. Berzins SP, Venanzi ES, Benoist C, Mathis D: T-cell compartments of prediabetic NOD mice. Diabetes 52:327-334, 2003
50. Chilton PM, Rezzoug F, Fugier-Vivier I, Weeter LA, Xu H, Huang Y, Ray MB, Ildstad ST: Flt3-ligand treatment prevents diabetes in NOD mice. Diabetes 53:1995-2002, 2004
51. Vasquez AC, Feili-Hariri M, Tan RJ, Morel PA: Qualitative and quantitative abnormalities in splenic dendritic cell populations in NOD mice. Clin Exp Immunol 135:209-218, 2004
52. Prasad SJ, Goodnow CC: Cell-intrinsic effects of non-MHD NOD genes on dendritic cell generation in vivo. Int Immunol 14:667-684, 2002
53. Langmuir PB, Bridgett MM, Bothwell AL, Crispe IN: Bone marrow abnormalities in the non-obese diabetic mouse. Int Immunol 5:169-177, 1993
54. Wicker LS, Miller BJ, Coker LZ, McNally SE, Scott S, Mullen Y, Appel MC: Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med 165:1639-1654, 1987