Experimental basis of hematopoietic stem cell transplantation for treatment of autoimmune diseases

Journal of Leukocyte Biology

Volumn 72, Issue 4, 2002, Pages 609-620

  Van Bekkum, D W ^a  

^a CRUCELL HOLLAND BV   (Netherlands)

Author keywords

Arthritis; Bone marrow; Encephalomyelitis; Transplants

Indexed keywords

ADJUVANT ARTHRITIS; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; AUTOIMMUNE DISEASE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; DISEASE SEVERITY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; INBRED STRAIN; MOLECULAR RECOGNITION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RELAPSE; REMISSION; REVIEW; STROMA CELL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNE DISEASES; BONE MARROW TRANSPLANTATION; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MULTIPLE SCLEROSIS; RATS; RODENTIA; TRANSPLANTATION, HOMOLOGOUS;

ANIMALIA;

EID: 0036826849     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (94)

1. Morton, J. I., Siegel, B. V. (1974) Transplantation of autoimmune potential. I. Development of antinuclear antibodies in H-2 histocompatible recipients of bone marrow from New Zealand Black mice. Proc. Natl. Acad. Sci. USA 71, 2162-2165.
2. Marmont, A. M. (1994) Immune ablation followed by allogeneic or autologous bone marrow transplantation: a new treatment for severe autoimmune diseases? Stem Cells 12, 125-135.
3. Charon, D. (1990) Molecular basis for human leukocyte antigen class II associations. Adv. Immunol. 48, 107-159.
4. Silman, A. J., MacGregor, A. J., Thomson, W., Holligan, S., Carthy, D., Farhan, A., Ollier, W, E. (1993) Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br. J. Rheumatol. 32, 903-907.
5. Taurog, J. D., Richardson, J. A., Croft, J. T., Simmons, W. A., Zhou, M., Fernandez-Sueiro, J. L., Balish, E., Hammer, R, E. (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180, 2359-2364.
6. Unnik, K. (1975) Comparative study of NZB mice under germfree and controlled conditions. J. Rheumatol. 2, 36-44.
7. Maldonado, M. A., Kakkanaiah, V., MacDonald, G. C., Chen, F., Reap, E. A., Balish, E., Farkas, W. R., Jennette, J. C., Madaio, M. P., Kotzin, B. L., Cohen, P. L., Eisenberg, R. A. (1999) The role of environmental antigens in the spontaneous development of autoimmunity in MRL-Ipr mice. J. Immunol. 162, 6322-6330.
8. Thomas, V. A., Woda, B. A., Handler, E. S., Greiner, D. L., Mordes, J. P., Rossini, A. A. (1991) Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens. Diabetes 40, 255-258.
9. Ellerman, K. E., Richards, C. A., Guberski, D. L., Shek, W. R., Like, A. A. (1996) Kilham rat triggers T-cell-dependent autoimmune diabetes in multiple strains of rat. Diabetes 45, 557-562.
10. Like, A. A., Guberski, D. L., Butler, L. (1991) Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats. Diabetes 40, 259-262.
11. Wang, G. S., Gruber, H., Smyth, P., Pulido, O., Rosenberg, L., Duguid, W., Scott, F. W. (2000) Hydrolysed casein diet protects BB rats from developing diabetes by promoting islet neogenesis. J. Autoimmun. 15, 407-416.
12. Williams, A. J., Krug, J., Lampeter, E. F., Mansfield, K., Beales, P. E., Signore, A., Gale, E. A., Pozzilli, P. (1990) Raised temperature reduces the incidence of diabetes in the NOD mouse. Diabetologia 33, 635-637.
13. Carter, W. R., Herrman, J., Stokes, K., Cox, D. J. (1987) Promotion of diabetes onset by stress in the BB rat. Diabetologia 30, 674-675.
14. Hunger, R. E., Carnaud, C., Vogt, I., Mueller, C. (1998) Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. J. Clin. Investig. 101, 1300-1309.
15. Kohashi, O., Kuwata, J., Umehara, K., Uemura, F., Takahashi, T., Ozawa, A. (1979) Susceptibility to adjuvant-induced arthritis among germfree, specific- pathogen-free, and conventional rats. Infect. Immun. 26, 791-794.
16. Breban, M. A., Moreau, M. C., Fournier, C., Ducluzeau, R., Kahn, M. F. (1993) Influence of the bacterial flora on collagen-induced arthritis in susceptible and resistant strains of rats. Clin. Exp. Rheumatol. 11, 61-64.
17. van Bekkum, D. W., Knaan, S. (1977) Role of bacterial microflora in development of intestinal lesions from graft-versus-host reaction. J. Natl. Cancer Inst. 58, 787-790.
18. Heidt, P. J., Vossen, J. M. (1992) Experimental and clinical gnotobiotics: influence of the microflora on graft-versus-host disease after allogeneic bone marrow transplantation. J. Med. 23, 161-173.
19. Mason, D., MacPhee, I., Antoni, F. (1990) The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat. Immunology 70, 1-5.
20. van Gelder, M., Kinwel-Bohre, E. P., Mulder, A. H., van Bekkum, D. (1996) Both bone marrow- and non-bone marrow-associated factors determine susceptibility to experimental autoimmune encephalomyelitis of BUF and WAG rats. Cell. Immunol. 168, 39-48.
21. Mostarica-Stojkovic, M., Petrovic, M., Lukic, M. L. (1982) Resistance to the induction of EAE in AO rats: its prevention by the pre-treatment with cyclophosphamide or low dose of irradiation. Clin. Exp. Immunol. 50, 311-317.
22. Lando, Z., Teitelbaum, D., Amon, R. (1980) Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice. Nature 287, 551-552.
23. de Vries, M. J., van Putten, L. M., Balner, H., van Bekkum, D. W. (1964) Lésions suggérant une réactivité autoimmune chez des souris atteintes de la "runt disease" après thymectomie nèonatale. Rev. Fr. Etud. Clin. Biol. 9, 381-397.
24. Bos, G. M., Majoor, G. D., Van Breda Vriesman, P. J. (1989) Perturbation of T-cell differentiation in lethally irradiated rats reconstituted with syngeneic bone marrow and treated with cyclosporin-A. Thymus 14, 155-161.
25. Sardina, E. E., Sugiura, K., Ikehara, S., Good, R. A. (1991) Transplantation of wheat germ agglutinin-positive hematopoietic cells to prevent or induce systemic autoimmune disease. Proc. Natl. Acad. Sci. USA 88, 3218-3222.
26. de Heer, D. H., Edgington, T. S. (1977) Evidence for a B lymphocyte defect underlying the anti-X anti-erythrocyte autoantibody response of NZB mice. J. Immunol. 118, 1858-1863.
27. Morton, J. I., Siegel, B. V. (1979) Transplantation of autoimmune potential. IV. Reversal of the NZB autoimmune syndrome by bone marrow transplantation. Transplantation 27, 133-134.
28. Ikehara, S., Inaba, M., Ishida, T., Ogata, H., Hisha, H., Yasumizu, R., Oyaizu, N., Sugiura, K., Toki, J., Takao, F., Than, S., Kawamura, M., Nishioka, N., Nagata, N., Good, R. A. (1991) Rationale for transplantation of both allogeneic bone marrow and stromal cells in the treatment of autoimmune diseases. In New Strategies in Bone Marrow Transplantation: UCLA Symposia on Molecular and Cellular Biology, New Series, vol. 137 (R. E. Champlin, R. P. Gale, eds.), New York, NY, Wiley-Liss, 251.
29. Miyashima, S., Nagata, N., Nakagawa, T., Hosaka, N., Takeuchi, K., Ogawa, R., Ikehara, S. (1996) Prevention of Ipr-graft-versus-host disease and transfer of autoimmune diseases in normal C57BL/6 mice by transplantation of bone marrow cells plus bones (stromal cells) from MRL/Ipr mice. J. Immunol. 156, 79-84.
30. Ikehara, S., Kawamura, M., Takao, F., Inaba, M., Yasumizu, R., Than, S., Hisha, H., Sugiura, K., Koide, Y., Yoshida, T. O., et al. (1990) Organ-specific and systemic autoimmune diseases originate from defects in hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 87, 8341-8344.
31. Himeno, K., Good, R. A. (1988) Marrow transplantation from tolerant donors to treat and prevent autoimmune diseases in BXSB mice. Proc. Natl. Acad. Sci. USA 85, 2235-2239.
32. Nakagawa, T., Nagata, N., Hosaka, N., Ogawa, R., Nakamura, K., Ikehara, S. (1993) Prevention of autoimmune inflammatory polyarthritis in male New Zealand black/KN mice by transplantation of bone marrow cells plus bone (stromal cells). Arthritis Rheum. 36, 263-268.
33. Serreze, D. V., Leiter, E. H., Worthen, S. M., Shultz, L. D. (1988) NOD marrow stem cells adoptively transfer diabetes to resistant (NOD × NON)F1 mice. Diabetes 37, 252-255.
34. Wicker, L. S., Miller, B. J., Chai, A., Terada, M., Mullen, Y. (1988) Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells. Transfer of diabetes and insulitis to nondiabetic (NOD × B10) F1 mice with bone marrow cells from NOD mice. J. Exp. Med. 167, 1801-1810.
35. LaFace, D. M., Peck, A. B. (1989) Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 38, 894-901.
36. Naji, A., Silvers, W. K., Kimura, H., Anderson, A. O., Barker, C. F. (1983) Influence of islet and bone marrow transplantation on the diabetes and immunodeficiency of BB rats. Metabolism 32, 62-68.
37. Scott, J., Engelhard, V. H., Benjamin, D. C. (1987) Bone marrow irradiation chimeras in the BB rat: evidence suggesting two defects leading to diabetes and lymphopoenia. Diabetologia 30, 774-781.
38. Kuntz, L., Montecino-Rodriguez, E., Jachez, B., Roman, D., Loor, F. (1991) Adoptive transfer of viable motheaten pathology in sublethally irradiated beige recipient mice. Immunology 73, 356-362.
39. Walker, M. A., Harley, R. A., DeLustro, F. A., LeRoy, E. C. (1989) Adoptive transfer of tsk skin fibrosis to +/+ recipients by tsk bone marrow and spleen cells. Proc. Soc. Exp. Biol. Med. 192, 196-200.
40. Breban, M., Hammer, R. E., Richardson, J. A., Taurog, J. D. (1993) Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J. Exp. Med. 178, 1607-1616.
41. van Bruggen, M. C., van den Broek, M. F., van den Berg, W. B. (1991) Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344 → Lewis and in Lewis → F344 bone marrow chimeras. Cell. Immunol. 136, 278-290.
42. van Bekkum, D. W. (1997) Autologous stem cell therapy for treatment of autoimmune diseases. In Autologous Marrow and Blood Transplantation: Proceedings of the Eigth International Symposium on Autologous Bone Marrow Transplantaion, Arlington, Texas (K. A. Dicke, A. Keating, eds.), Charlottesville, VA, Carden Jennings, 645-662.
43. Fujita, M., Mishima, M., Iwabuchi, K., Katsume, C., Gotohda, T., Ogasawara, K., Mizuno, Y., Good, R. A., Onoe, K. (1989) A study on type II collagen-induced arthritis in allogeneic bone marrow chimaeras. Immunology 66, 422-427.
44. Singer, D. E., Moore, M. J., Williams, R. M. (1981) EAE in rat bone marrow chimeras: analysis of the cellular mechanism of BN resistance. J. Immunol. 126, 1553-1557.
45. Ben-Nun, A., Otmy, H., Cohen, I. R. (1981) Genetic control of autoimmune encephalomyelitis and recognition of the critical nonapeptide moiety of myelin basic protein in guinea pigs are exerted through interaction of lymphocytes and macrophages. Eur. J. Immunol. 11, 311-316.
46. Pelfrey, C. M., Waxman, F. J., Whitacre, C. C. (1989) Genetic resistance in experimental autoimmune encephalomyelitis. I. Analysis of the mechanism of LeR resistance using radiation chimeras. Cell. Immunol. 122, 504-516.
47. Korngold, R., Feldman, A., Rorke, L. B., Lublin, F. D., Doherty, P. C. (1986) Acute experimental allergic encephalomyelitis in radiation bone marrow chimeras between high and low susceptible strains of mice. Immunogeneties 24, 309-315.
48. Lublin, F. D., Knobler, R. L., Doherty, P. C., Korngold, R. (1986) Relapsing experimental allergic encephalomyelitis in radiation bone marrow chimeras between high and low susceptible strains of mice. Clin. Exp. Immunol. 66, 491-496.
49. Binder, T. A., Greiner, D. L., Grunnet, M., Goldschneider, I. (1993) Relative susceptibility of SJL/J and B10.S mice to experimental allergic encephalomyelitis (EAE) is determined by the ability of prethymic cells in bone marrow to develop into EAE effector T cells. J. Neuroimmunol. 42, 23-32.
50. van Gelder, M., van Bekkum, D. W. (1995) Treatment of relapsing experimental autoimmune encephalomyelitis in rats with allogeneic bone marrow transplantation from a resistant strain. Bone Marrow Transplant. 16, 343-351.
51. van Gelder, M., Mulder, A. H., van Bekkum, D. W. (1996) Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-matched allogeneic bone marrow transplantation. Transplantation 62, 810-818.
52. Jones, R. E., Bourdette, D. N., Whitham, R. H., Offner, H., Vandenbark, A. A. (1993) Induction of experimental autoimmune encephalomyelitis in severe combined immunodeficient mice reconstituted with allogeneic or xenogeneic hematopoietic cells. J. Immunol. 150, 4620-4629.
53. Ikehara, S., Good, R. A., Nakamura, T., Sekita, K., Inoue, S., Oo, M. M., Muso, E., Ogawa, K., Hamashima, Y. (1985) Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proc. Natl. Acad. Sci. USA 82, 2483-2487.
54. Ikehara, S., Ohtsuki, H., Good, R. A., Asamoto, H., Nakamura, T., Sekita, K., Muso, E., Tochino, Y., Ida, T., Kuzuya, H. (1985) Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation. Proc. Natl. Acad. Sci. USA 82, 7743-7747.
55. Ikehara, S., Yasumizu, R., Inaba, M., Izui, S., Hayakawa, K., Sekita, K., Toki, J., Sugiura, K., Iwai, H., Nakamura, T., et al. (1989) Long-term observations of autoimmune-prone mice treated for autoimmune disease by allogeneic bone marrow transplantation. Proc. Natl. Acad. Sci. USA 86, 3306-3310.
56. Ishida, T., Inaba, M., Hisha, H., Sugiura, K., Adachi, Y., Nagata, N., Ogawa, R., Good, R. A., Ikehara, S. (1994) Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune diseases in MRL/MP-Ipr/Ipr mice by transplantation of bone marrow plus bones (stromal cells) from the same donor. J. Immunol. 152, 3119-3127.
57. Hosaka, N., Nose, M., Kyogoku, M., Nagata, N., Miyashima, S., Good, R. A., Ikehara, S. (1996) Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice. Proc. Natl. Acad. Sci. USA 93, 8558-8562.
58. van Bekkum, D. W., Bohre, E. P., Houben, P. F., Knaan-Shanzer, S. (1989) Regression of adjuvant-induced arthritis in rats following bone marrow transplantation. Proc. Natl. Acad. Sci. USA 86, 10090-10094.
59. Kamiya, M., Sohen, S., Yamane, T., Tanaka, S. (1993) Effective treatment of mice with type II collagen induced arthritis with lethal irradiation and bone marrow transplantation. J. Rheumatol. 20, 225-230.
60. Van Gelder, M. (1995) Bone Marrow Transplantation for Treatment of Experimental Autoimmune Encephalomyelitis in Rats. Prospects for Therapy of Severe Multiple Sclerosis, 1-163, Rijks Universiteit Leiden, Leiden, Ph.D. thesis.
61. Marmont, A. M. (2001) Immunoablation followed or not by hematopoietic stem cells as an intense therapy for severe autoimmune diseases. New perspectives, new problems. Haematologica 86, 337-345.
62. Nelson, J. L., Torrez, R., Louie, F. M., Choe, O. S., Storb, R., Sullivan, K. M. (1997) Pre-existing autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation. J. Rheumatol. Suppl. 48, 23-29.
63. Tyndall, A. (2001) Autologous hematopoietic stem cell transplantation for severe autoimmune disease with special reference to rheumatoid arthritis. J. Rheumatol. Suppl. 64, 5-7.
64. Knaan-Shanzer, S., Houben, P., Kinwel-Bohre, E. P., van Bekkum, D. W. (1991) Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant. 8, 333-338.
65. Pestronk, A., Drachman, D. B., Teoh, R., Adams, R. N. (1983) Combined short-term immunotherapy for experimental autoimmune myasthenia gravis, Ann. Neurol. 14, 235-241.
66. van Bekkum, D. W. (2000) Conditioning regimens for the treatment of experimental arthritis with autologous bone marrow transplantation. Bone Marrow Transplant. 25, 357-364.
67. van Gelder, M., Kinwel-Bohre, E. P., van Bekkum, D. W. (1993) Treatment of experimental allergic encephalomyelitis in rats with total body irradiation and syngeneic BMT. Bone Marrow Transplant. 11, 233-241.
68. van Gelder, M., van Bekkum, D. W. (1996) Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant. 18, 1029-1034.
69. Karussis, D. M., Slavin, S., Ben-Nun, A., Ovadia, H., Vourka-Karussis, U., Lehmann, D., Mizrachi-Kol, R., Abramsky, O. (1992) Chronic-relapsing experimental autoimmune encephalomyelitis (CR-EAE): treatment and induction of tolerance, with high dose cyclophosphamide followed by syngeneic bone marrow transplantation. J. Neuroimmunol. 39, 201-210.
70. Good, R. A., Ikehara, S. (1997) Preelinical investigations that subserve efforts to employ bone marrow transplantation for rheumatoid or autoimmune diseases. J. Rheumatol. Suppl. 48, 5-12.
71. Karussis, D. M., Vourka-Karussis, U., Lehmann, D., Abramsky, O., Ben-Nun, A., Slavin, S. (1995) Immunomodulation of autoimmunity in MRL/Ipr mice with syngeneic bone marrow transplantation (SBMT). Clin. Exp. Immunol. 100, 111-117.
72. Loor, F., Jachez, B., Montecino-Rodriguez, E., Klein, A. S., Kuntz, L., Pflumio, F., Fonteneau, P., Illinger, D. (1988) Radiation therapy of spontaneous autoimmunity: a review of mouse models. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 53, 119-136.
73. Smith, H. R., Chused, T. M., Steinberg, A. D. (1984) Cyclophosphamide-induced changes in the MRL-Ipr/Ipr mouse: effects upon cellular composition, immune function, and disease. Clin. Immunol. Immunopathol. 30, 51-61.
74. Karussis, D. M., Slavin, S., Lehmann, D., Mizrachi-Koll, R., Abramsky, O., Ben-Nun, A. (1992) Prevention of experimental autoimmune encephalomyelitis and induction of tolerance with acute immunosuppression followed by syngeneic bone marrow transplantation. J. Immunol. 148, 1693-1698.
75. Burt, R. K., Padilla, J., Begolka, W. S., Canto, M. C., Miller, S. D. (1998) Effect of disease stage on clinical outcome after syngeneic bone marrow transplantation for relapsing experimental autoimmune encephalomyelitis. Blood 91, 2609-2616.
76. Orme, I. M. (1988) Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection. J. Immunol. 140, 3589-3593.
77. Burt, R. K., Traynor, A. E., Pope, R., Schroeder, J., Cohen, B., Karlin, K. H., Lobeck, L., Goolsby, C., Rowlings, P., Davis, F. A., Stefoski, D., Terry, C., Keever-Taylor, C., Rosen, S., Vesole, D., Fishman, M., Brush, M., Mujias, S., Villa, M., Bums, W. H. (1998) Treatment of autoimmune disease by intense immunosuppressive conditioning and autologous hematopoietic stem cell transplantation. Blood 92, 3505-3514.
78. Fassas, A., Anagnostopoulos, A., Kazis, A., Kapinas, K., Sakellari, I., Kimiskidis, V., Tsompanakou, A. (1997) Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant. 20, 631-638.
79. Wulffraat, N. M., Sanders, L. A., Kuis, W. (2000) Autologous hemopoietic stem-cell transplantation for children with refractory autoimmune disease. Curr. Rheumatol. Rep. 2, 316-323.
80. van Bekkum, D. W. (1970) Mitigation of acute secundary disease by treatment of the recipient with antilymphocyte serum before grafting of hemopoietic cells. Exp. Hematol. 20, 3-4.
81. van Bekkum, D. W., Balner, H., Dicke, K. A., van den Berg, F. G., Prinsen, G. H., Hollander, C. F. (1972) The effect of pretreatment of allogeneic bone marrow graft recipients with antilymphocytic serum on the acute graft-versus-host reaction in monkeys. Transplantation 13, 400-407.
82. Brodsky, R. A. (1999) Immunoabblative treatment of autoimmune diseases without stem cell transplantation suppor. In Symposium on Autoimmune Disease, Immunoablation and Stem Cells: Towards Y2K, 28th Annual Meeting ISEH, Monte Carlo.
83. van Bekkum, D. W. (1999) Effectiveness and risks of total body irradiation for conditioning in the treatment of autoimmune disease with autologous bone marrow transplantation. Rheumatology (Oxford) 38, 757-761.
84. Zurcher, C., Varekamp, A. E., Solleveld, H. A., Durham, S. K., De Vries, A. J., Hagenbeek, A. (1987) Late effects of cyclophosphamide and total body irradiation as a conditioning regimen for bone marrow transplantation in rats (a preliminary report). Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51, 1059-1068.
85. Radis, C. D., Kahl, L. E., Baker, G. L., Wasko, M. C., Cash, J. M., Gallatin, A., Stolzer, B. L., Agarwal, A. K., Medsger Jr., T. A., Kwoh, C. K. (1995) Effects of cyclophosphamide on the development of malignancy and on long-term survival of patients with rheumatoid arthritis. A 20-year followup study. Arthritis Rheum. 38, 1120-1127.
86. Dantal, J., Hourmant, M., Cantarovich, D., Giral, M., Blancho, G., Dreno, B., Soulillou, J. P. (1998) Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens. Lancet 351, 623-628.
87. Chan, K. W., Li, C. K., Worth, L. L., Chik, K. W., Jeha, S., Shing, M. K., Yuen, P. M. (2001) A fludarabine-based conditioning regimen for severe aplastic anemia. Bone Marrow Transplant. 27, 125-128.
88. Nishio, M., Nakao, S., Endo, T., Fujimoto, K., Takashima, H., Sakai, T., Bacigalupo, A., Koike, T., Sawada, K. (2001) Successful non-myeloablative stem cell transplantation for a heavily transfused woman with severe aplastic anemia complicated by heart failure. Bone Marrow Transplant. 28, 783-785.
89. Goodman, E. R., Fiedor, P. S., Fein, S., Athan, E., Hardy, M. A. (1996) Fludarabine phosphate: a DNA synthesis inhibitor with potent immunosuppressive activity and minimal clinical toxicity. Am. Surg. 62, 435-442.
90. Davis Jr., J. C., Fessler, B. J., Tassiulas, I. O., McInnes, I. B., Yarboro, C. H., Pillemer, S., Wilder, R., Fleisher, T. A., Klippel, J. H., Boumpas, D. T. (1998) High dose versus low dose fludarabine in the treatment of patients with severe refractory rheumatoid arthritis. J. Rheumatol. 25, 1694-1704.
91. Rabusin, M., Andolina, M., Maximova, N., Lepore, L., Parco, S., Tuveri, G., Jankovic, G. (2000) Immunoablation followed by autologous hematopoietic stem cell infusion for the treatment of severe autoimmune disease. Haematologica 85, 81-85.
92. Burt, R. K., Bums, W., Ruvolo, P., Fischer, A., Shiao, C., Guimaraes, A., Barrett, J., Hess, A. (1995) Syngeneic bone marrow transplantation eliminates V beta 8.2 T lymphocytes from the spinal cord of Lewis rats with experimental allergic encephalomyelitis. J. Neurosci. Res. 41, 526-531.
93. Euler, H. H., Marmont, A. M., Bacigalupo, A., Fastenrath, S., Dreger, P., Hoffknecht, M., Zander, A. R., Schalke, B., Hahn, U., Haas, R., Schmitz, N. (1996) Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood 88, 3621-3625.
94. Tyndall, A., Grathwol, A. (1997) Concensus statement on blood and stemcell transplantation in autoimmune disease. Br. J. Rheumatol. 36, 90-92.