Endotoxin impairs biliary transport of sparfloxacin and its glucuronide in rats

European Journal of Pharmacology

Volumn 432, Issue 1, 2001, Pages 99-105

  Nadai, Masayuki ^a   Zhao, Ying Lan ^b,c   Wang, Li ^b,d   Nishio, Yuki ^b   Takagi, Kenji ^b   Kitaichi, Kiyoyuki ^b   Takagi, Kenzo ^b   Yoshizumi, Hideo ^a   Hasegawa, Takaaki ^b  

^a MEIJO UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c SCHOOL OF BASIC MEDICAL SCIENCES   (China)

^d WEST CHINA UNIVERSITY OF MEDICAL SCIENCES   (China)

Author keywords

(Rat); Biliary excretion; Canalicular multispecific organic anion transporter; Endotoxin; P glycoprotein; Quinolone antimicrobial agent; Sparfloxacin

Indexed keywords

4 NITROPHENYLGLUCURONIDE; ANTIINFECTIVE AGENT; ENDOTOXIN; SPARFLOXACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG TRANSPORT; HEPATOBILIARY SYSTEM; KIDNEY CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; BILE DUCTS; BIOLOGICAL TRANSPORT; ENDOTOXINS; FLUOROQUINOLONES; GLUCURONIDES; LIVER; MALE; METABOLIC CLEARANCE RATE; NITROPHENOLS; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 0035976811     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01470-4     Document Type: Article

References (38)

1. 14C]-grepafloxacin in rats
2. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: Impaired uptake and secretion
3. Dexamethasone prevents the growth inhibitory effects of recombinant tumor necrosis factor in a rat hepatoma cell line Reuber-RC-3: An association with the changes in the messenger RNA levels for multidrug resistance gene
4. Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors
5. Active intestinal elimination of ciprofloxacin in rats: Modulation by different substrates
6. Comparative endotoxin-induced hepatic injury in young and aged rats
7. Agonists and antagonists for lipopolysaccharide-induced cytokines
8. Effects of organic anions and bile acid conjugates on biliary excretion of pravastatin in the rat
9. Effect of a bacterial lipopolysaccharide on biliary excretion of a β-lactam antibiotic, cefoperazone, in rats
10. Renal excretion of famotidine and role of adenosine in renal failure induced by bacterial lipopolysaccharide in rats
11. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides
12. Effect of endotoxin on rat liver: Analysis of acid phosphatese isozymes in the liver of normal and endotoxin-treated rats
13. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)
14. Induction of mdr1b mRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte cultures
15. Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1
16. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2
17. Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2
18. Decreased antipyrine clearance following endotoxin administration: In vivo evidence of the role of nitric oxide
19. Pharmacokinetic evidence for the occurrence of extrahepatic conjugative metabolism of p-nitrophenol in rats
20. 14C-sparfloxacin in the rat
21. Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier
22. Alterations in pharmacokinetics and protein binding behavior of cefazolin in endotoxemic rats
23. The disposition and renal handling of enprofylline in endotoxemic rats by bacterial lipopolysaccharide (LPS)
24. Alterations in renal uptake kinetics of the xanthine derivatives enprofylline in endotoxaemic mice
25. Time-dependent effects of Klebsiella pneumoniae endotoxin on hepatic drug-metabolizing enzyme activity in rats
26. Kupffer cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression
27. Stereoselectivity of ofloxacin intestinal transport in the rat
28. Decreased bilirubin transport in the perfused liver of endotoxemic rats
29. Impaired hepatocanalicular organic anion transport in endotoxemic rats
30. Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats
31. Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2)
32. Cytokines and the liver
33. Tumor necrosis factor-α and expression of the multidrug resistance-associated genes LRP and MRP
34. Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier
35. Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats
36. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
37. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
38. Possible involvement of P-glycoprotein on biliary excretion of grepafloxacin