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Volumn 94, Issue 5, 2005, Pages 982-994

Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue

Author keywords

Bone adaptation; Disuse; Gene expression; Mechanical loading; Osteoporosis

Indexed keywords

COLLAGEN TYPE 1; GELATINASE A; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; OSTEONECTIN; PRIMER DNA;

EID: 20044369779     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20363     Document Type: Article
Times cited : (54)

References (68)
  • 1
    • 0036128727 scopus 로고    scopus 로고
    • Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma
    • Ahdjoudj S, Lasmoles F, Holy X, Zerath E, Marie PJ. 2002. Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma. J Bone Miner Res 17:668-677.
    • (2002) J Bone Miner Res , vol.17 , pp. 668-677
    • Ahdjoudj, S.1    Lasmoles, F.2    Holy, X.3    Zerath, E.4    Marie, P.J.5
  • 2
    • 0023866509 scopus 로고
    • Effects of weightlessness on phospho-calcium metabolism and its hormonal regulation in man during the 51 G Franco-American space flight
    • Alexandre C, Vico L, Pilonchery G, Chapuy MC, Delmas PD, Chappard D. 1988. [Effects of weightlessness on phospho-calcium metabolism and its hormonal regulation in man during the 51 G Franco-American space flight]. Pathol Biol (Paris) 36:144-148.
    • (1988) Pathol Biol (Paris) , vol.36 , pp. 144-148
    • Alexandre, C.1    Vico, L.2    Pilonchery, G.3    Chapuy, M.C.4    Delmas, P.D.5    Chappard, D.6
  • 5
    • 0036207246 scopus 로고    scopus 로고
    • Metalloproteinases (MMPs-2, -3) are involved in TGF-beta and IGF-1-induced bone defect healing in 20-month-old female rats
    • Blumenfeld I, Srouji S, Peled M, Livne E. 2002. Metalloproteinases (MMPs-2, -3) are involved in TGF-beta and IGF-1-induced bone defect healing in 20-month-old female rats. Arch Gerontol Geriatr 35:59-69.
    • (2002) Arch Gerontol Geriatr , vol.35 , pp. 59-69
    • Blumenfeld, I.1    Srouji, S.2    Peled, M.3    Livne, E.4
  • 6
    • 0032822929 scopus 로고    scopus 로고
    • Osteoinductive growth factors in preclinical fracture and long bone defects models
    • Bostrom MP, Saleh KJ, Einhorn TA. 1999. Osteoinductive growth factors in preclinical fracture and long bone defects models. Orthop Clin North Am 30:647-658.
    • (1999) Orthop Clin North Am , vol.30 , pp. 647-658
    • Bostrom, M.P.1    Saleh, K.J.2    Einhorn, T.A.3
  • 7
    • 0035022957 scopus 로고    scopus 로고
    • SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
    • Bradshaw AD, Sage EH. 2001. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest 107:1049-1054.
    • (2001) J Clin Invest , vol.107 , pp. 1049-1054
    • Bradshaw, A.D.1    Sage, E.H.2
  • 8
    • 0027326105 scopus 로고
    • Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures
    • Canalis E, Pash J, Gabbitas B, Rydziel S, Varghese S. 1993. Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 133:33-38.
    • (1993) Endocrinology , vol.133 , pp. 33-38
    • Canalis, E.1    Pash, J.2    Gabbitas, B.3    Rydziel, S.4    Varghese, S.5
  • 9
    • 0031731864 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase blocks osteoclastic bone resorption in adaptive bone modeling
    • Chole RA, Tinling SP, Leverentz E, McGinn MD. 1998. Inhibition of nitric oxide synthase blocks osteoclastic bone resorption in adaptive bone modeling. Acta Otolaryngol 118:705-711.
    • (1998) Acta Otolaryngol , vol.118 , pp. 705-711
    • Chole, R.A.1    Tinling, S.P.2    Leverentz, E.3    McGinn, M.D.4
  • 10
    • 0031723256 scopus 로고    scopus 로고
    • Mechanical loading stimulates bone formation by reactivation of bone lining cells in 13-week-old rats
    • Chow JW, Wilson AJ, Chambers TJ, Fox SW. 1998. Mechanical loading stimulates bone formation by reactivation of bone lining cells in 13-week-old rats. J Bone Miner Res 13:1760-1767.
    • (1998) J Bone Miner Res , vol.13 , pp. 1760-1767
    • Chow, J.W.1    Wilson, A.J.2    Chambers, T.J.3    Fox, S.W.4
  • 12
    • 0037736569 scopus 로고    scopus 로고
    • Osteonectin-null mutation compromises osteoblast formation, maturation, and survival
    • Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. 2003. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology 144:2588-2596.
    • (2003) Endocrinology , vol.144 , pp. 2588-2596
    • Delany, A.M.1    Kalajzic, I.2    Bradshaw, A.D.3    Sage, E.H.4    Canalis, E.5
  • 13
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. 1997. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation [see comments]. Cell 89:747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 15
    • 0035409337 scopus 로고    scopus 로고
    • Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: Evidence for intrinsic glutamatergic signaling in bone
    • Genever PG, Skerry TM. 2001. Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: Evidence for intrinsic glutamatergic signaling in bone. FASEB J 15:1586-1588.
    • (2001) FASEB J , vol.15 , pp. 1586-1588
    • Genever, P.G.1    Skerry, T.M.2
  • 18
    • 0037214222 scopus 로고    scopus 로고
    • A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway
    • Hatton JP, Pooran M, Li CF, Luzzio C, Hughes-Fulford M. 2003. A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res 18:58-66.
    • (2003) J Bone Miner Res , vol.18 , pp. 58-66
    • Hatton, J.P.1    Pooran, M.2    Li, C.F.3    Luzzio, C.4    Hughes-Fulford, M.5
  • 20
    • 0036323768 scopus 로고    scopus 로고
    • Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein
    • Jiang GL, White CR, Stevens HY, Frangos JA. 2002. Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein. Am J Physiol Endocrinol Metab 283:E383-E389.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Jiang, G.L.1    White, C.R.2    Stevens, H.Y.3    Frangos, J.A.4
  • 21
    • 0033924276 scopus 로고    scopus 로고
    • High-impact exercise and growing bone: Relation between high strain rates and enhanced bone formation
    • Judex S, Zernicke RF. 2000. High-impact exercise and growing bone: Relation between high strain rates and enhanced bone formation. J Appl Physiol 88:2183-2191.
    • (2000) J Appl Physiol , vol.88 , pp. 2183-2191
    • Judex, S.1    Zernicke, R.F.2
  • 22
    • 0036676971 scopus 로고    scopus 로고
    • Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton
    • Judex S, Donahue LR, Rubin C. 2002. Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J 16:1280-1282.
    • (2002) FASEB J , vol.16 , pp. 1280-1282
    • Judex, S.1    Donahue, L.R.2    Rubin, C.3
  • 23
    • 0038487127 scopus 로고    scopus 로고
    • Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load
    • Judex S, Boyd S, Qin YX, Turner S, Ye K, Muller R, Rubin C. 2003. Adaptations of trabecular bone to low magnitude vibrations result in more uniform stress and strain under load. Ann Biomed Eng 31:12-20.
    • (2003) Ann Biomed Eng , vol.31 , pp. 12-20
    • Judex, S.1    Boyd, S.2    Qin, Y.X.3    Turner, S.4    Ye, K.5    Muller, R.6    Rubin, C.7
  • 25
    • 0038688373 scopus 로고    scopus 로고
    • The complexities of skeletal biology
    • Karsenty G. 2003. The complexities of skeletal biology. Nature 423:316-318.
    • (2003) Nature , vol.423 , pp. 316-318
    • Karsenty, G.1
  • 26
    • 0032546451 scopus 로고    scopus 로고
    • Mechanotransduction in stretched osteocytes-temporal expression of immediate early and other genes
    • Kawata A, Mikuni-Takagaki Y. 1998. Mechanotransduction in stretched osteocytes-temporal expression of immediate early and other genes. Biochem Biophys Res Commun 246:404-408.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 404-408
    • Kawata, A.1    Mikuni-Takagaki, Y.2
  • 27
    • 0141939435 scopus 로고    scopus 로고
    • The efficiency of pooling mRNA in microarray experiments
    • Kendziorski CM, Zhang Y, Lan H, Attie AD. 2003. The efficiency of pooling mRNA in microarray experiments. Biostatistics 4:465-477.
    • (2003) Biostatistics , vol.4 , pp. 465-477
    • Kendziorski, C.M.1    Zhang, Y.2    Lan, H.3    Attie, A.D.4
  • 28
    • 0029617377 scopus 로고
    • Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts-correlation with prostaglandin upregulation
    • Klein-Nulend J, Semeins CM, Ajubi NE, Nijweide PJ, Burger EH. 1995. Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts-correlation with prostaglandin upregulation. Biochem Biophys Res Commun 217:640-648.
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 640-648
    • Klein-Nulend, J.1    Semeins, C.M.2    Ajubi, N.E.3    Nijweide, P.J.4    Burger, E.H.5
  • 29
    • 0028929151 scopus 로고
    • Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation
    • Lean JM, Jagger CJ, Chambers TJ, Chow JW. 1995. Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol 268:E318-E327.
    • (1995) Am J Physiol , vol.268
    • Lean, J.M.1    Jagger, C.J.2    Chambers, T.J.3    Chow, J.W.4
  • 30
    • 0029839607 scopus 로고    scopus 로고
    • Osteocytic expression of mRNA for c-fos and IGF-I: An immediate early gene response to an osteogenic stimulus
    • Lean JM, Mackay AG, Chow JW, Chambers TJ. 1996. Osteocytic expression of mRNA for c-fos and IGF-I: An immediate early gene response to an osteogenic stimulus. Am J Physiol 270:E937-E945.
    • (1996) Am J Physiol , vol.270
    • Lean, J.M.1    Mackay, A.G.2    Chow, J.W.3    Chambers, T.J.4
  • 31
    • 0034659898 scopus 로고    scopus 로고
    • Genomics, gene expression and DNA arrays
    • Lockhart DJ, Winzeler EA. 2000. Genomics, gene expression and DNA arrays. Nature 405:827-836.
    • (2000) Nature , vol.405 , pp. 827-836
    • Lockhart, D.J.1    Winzeler, E.A.2
  • 32
    • 0034232665 scopus 로고    scopus 로고
    • Compressive compared with tensile loading of medial collateral ligament scar in vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase
    • Majima T, Marchuk LL, Sciore P, Shrive NG, Frank CB, Hart DA. 2000. Compressive compared with tensile loading of medial collateral ligament scar in vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase. J Orthop Res 18:524-531.
    • (2000) J Orthop Res , vol.18 , pp. 524-531
    • Majima, T.1    Marchuk, L.L.2    Sciore, P.3    Shrive, N.G.4    Frank, C.B.5    Hart, D.A.6
  • 33
    • 0027080592 scopus 로고
    • Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines
    • Meikle MC, Bord S, Hembry RM, Compston J, Croucher PI, Reynolds JJ. 1992. Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines. J Cell Sci 103(Pt 4):1093-1099.
    • (1992) J Cell Sci , vol.103 , Issue.PART 4 , pp. 1093-1099
    • Meikle, M.C.1    Bord, S.2    Hembry, R.M.3    Compston, J.4    Croucher, P.I.5    Reynolds, J.J.6
  • 34
    • 0034125307 scopus 로고    scopus 로고
    • An in vivo model for investigations of mechanical signal transduction in trabecular bone
    • Moalli MR, Caldwell NJ, Patil PV, Goldstein SA. 2000. An in vivo model for investigations of mechanical signal transduction in trabecular bone. J Bone Miner Res 15:1346-1353.
    • (2000) J Bone Miner Res , vol.15 , pp. 1346-1353
    • Moalli, M.R.1    Caldwell, N.J.2    Patil, P.V.3    Goldstein, S.A.4
  • 35
    • 0036092597 scopus 로고    scopus 로고
    • Hindlimb unloading rodent model: Technical aspects
    • Morey-Holton ER, Globus RK. 2002. Hindlimb unloading rodent model: Technical aspects. J Appl Physiol 92:1367-1377.
    • (2002) J Appl Physiol , vol.92 , pp. 1367-1377
    • Morey-Holton, E.R.1    Globus, R.K.2
  • 36
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 37
    • 0034192758 scopus 로고    scopus 로고
    • Molecular events caused by mechanical stress in bone
    • Nomura S, Takano-Yamamoto T. 2000. Molecular events caused by mechanical stress in bone. Matrix Biol 19:91-96.
    • (2000) Matrix Biol , vol.19 , pp. 91-96
    • Nomura, S.1    Takano-Yamamoto, T.2
  • 38
    • 0028957812 scopus 로고
    • Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: Implications for bone resorption
    • Okada Y, Naka K, Kawamura K, Matsumoto T, Nakanishi I, Fujimoto N, Sato H, Seiki M. 1995. Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: Implications for bone resorption. Lab Invest 72:311-322.
    • (1995) Lab Invest , vol.72 , pp. 311-322
    • Okada, Y.1    Naka, K.2    Kawamura, K.3    Matsumoto, T.4    Nakanishi, I.5    Fujimoto, N.6    Sato, H.7    Seiki, M.8
  • 39
    • 0037441546 scopus 로고    scopus 로고
    • Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation
    • Ontiveros C, McCabe LR. 2003. Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation. J Cell Biochem 88:427-437.
    • (2003) J Cell Biochem , vol.88 , pp. 427-437
    • Ontiveros, C.1    McCabe, L.R.2
  • 41
    • 0037262631 scopus 로고    scopus 로고
    • Low-intensity, high-frequency vibration appears to prevent the decrease in strength of the femur and tibia associated with ovariectomy of adult rats
    • Oxlund BS, Ortoft G, Andreassen TT, Oxlund H. 2003. Low-intensity, high-frequency vibration appears to prevent the decrease in strength of the femur and tibia associated with ovariectomy of adult rats. Bone 32:69-77.
    • (2003) Bone , vol.32 , pp. 69-77
    • Oxlund, B.S.1    Ortoft, G.2    Andreassen, T.T.3    Oxlund, H.4
  • 42
    • 0028362416 scopus 로고
    • Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone
    • Parfitt AM. 1994. Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55:273-286.
    • (1994) J Cell Biochem , vol.55 , pp. 273-286
    • Parfitt, A.M.1
  • 43
    • 0028908457 scopus 로고
    • Problems in the application of in vitro systems to the study of human bone remodeling
    • Parfitt AM. 1995. Problems in the application of in vitro systems to the study of human bone remodeling. Calcif Tissue Int 56(Suppl 1):S5-S7.
    • (1995) Calcif Tissue Int , vol.56 , Issue.SUPPL. 1
    • Parfitt, A.M.1
  • 44
    • 0034762894 scopus 로고    scopus 로고
    • Effect of mechanical loading on periodontal cells
    • Pavlin D, Gluhak-Heinrich J. 2001. Effect of mechanical loading on periodontal cells. Crit Rev Oral Biol Med 12:414-424.
    • (2001) Crit Rev Oral Biol Med , vol.12 , pp. 414-424
    • Pavlin, D.1    Gluhak-Heinrich, J.2
  • 45
    • 0024241605 scopus 로고
    • Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading
    • Pead MJ, Skerry TM, Lanyon LE. 1988. Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res 3:647-656.
    • (1988) J Bone Miner Res , vol.3 , pp. 647-656
    • Pead, M.J.1    Skerry, T.M.2    Lanyon, L.E.3
  • 46
    • 0037468456 scopus 로고    scopus 로고
    • Preliminary characterisation of rnechanoresponsive regions of the c-fos promoter in bone cells
    • Peake MA, el Haj AJ. 2003. Preliminary characterisation of rnechanoresponsive regions of the c-fos promoter in bone cells. FEBS Lett 537:117-120.
    • (2003) FEBS Lett , vol.537 , pp. 117-120
    • Peake, M.A.1    El Haj, A.J.2
  • 47
    • 0037212119 scopus 로고    scopus 로고
    • Effect of micromechanical stimulations on osteoblasts: Development of a device simulating the mechanical situation at the bone-implant interface
    • Pioletti DP, Muller J, Rakotomanana LR, Corbeil J, Wild E. 2003. Effect of micromechanical stimulations on osteoblasts: Development of a device simulating the mechanical situation at the bone-implant interface. J Biomech 36:131-135.
    • (2003) J Biomech , vol.36 , pp. 131-135
    • Pioletti, D.P.1    Muller, J.2    Rakotomanana, L.R.3    Corbeil, J.4    Wild, E.5
  • 48
    • 0029564705 scopus 로고
    • Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone (re)modeling?
    • Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE. 1995. Mechanical strain-induced NO production by bone cells: A possible role in adaptive bone (re)modeling? FASEB J 9:1614-1622.
    • (1995) FASEB J , vol.9 , pp. 1614-1622
    • Pitsillides, A.A.1    Rawlinson, S.C.2    Suswillo, R.F.3    Bourrin, S.4    Zaman, G.5    Lanyon, L.E.6
  • 49
    • 0032710526 scopus 로고    scopus 로고
    • Expression profiles of mRNAs for osteoblast and osteoclast proteins as indicators of bone loss in mouse immobilization osteopenia model
    • Rantakokko J, Uusitalo H, Jamsa T, Tuukkanen J, Aro HT, Vuorio E. 1999. Expression profiles of mRNAs for osteoblast and osteoclast proteins as indicators of bone loss in mouse immobilization osteopenia model. J Bone Miner Res 14:1934-1942.
    • (1999) J Bone Miner Res , vol.14 , pp. 1934-1942
    • Rantakokko, J.1    Uusitalo, H.2    Jamsa, T.3    Tuukkanen, J.4    Aro, H.T.5    Vuorio, E.6
  • 50
    • 0030976489 scopus 로고    scopus 로고
    • Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues
    • Reno C, Marchuk L, Sciore P, Frank CB, Hart DA. 1997. Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues. Biotechniques 22:1082-1086.
    • (1997) Biotechniques , vol.22 , pp. 1082-1086
    • Reno, C.1    Marchuk, L.2    Sciore, P.3    Frank, C.B.4    Hart, D.A.5
  • 51
    • 0033933185 scopus 로고    scopus 로고
    • Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells
    • Rubin J, Murphy T, Nanes MS, Fan X. 2000. Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am J Physiol Cell Physiol 278:C1126-C1132.
    • (2000) Am J Physiol Cell Physiol , vol.278
    • Rubin, J.1    Murphy, T.2    Nanes, M.S.3    Fan, X.4
  • 53
    • 0034814210 scopus 로고    scopus 로고
    • The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli
    • Rubin C, Xu G, Judex S. 2001b. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J 15:2225-2229.
    • (2001) FASEB J , vol.15 , pp. 2225-2229
    • Rubin, C.1    Xu, G.2    Judex, S.3
  • 54
    • 0036155477 scopus 로고    scopus 로고
    • Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, non-invasive mechanical intervention
    • Rubin C, Turner AS, Muller R, Mittra E, McLeod K, Lin W, Qin YX. 2002. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, non-invasive mechanical intervention. J Bone Miner Res 17:349-357.
    • (2002) J Bone Miner Res , vol.17 , pp. 349-357
    • Rubin, C.1    Turner, A.S.2    Muller, R.3    Mittra, E.4    McLeod, K.5    Lin, W.6    Qin, Y.X.7
  • 55
    • 0141706659 scopus 로고    scopus 로고
    • Mechanical strain differentially regulates eNOS and RANKL expression via ERK1/2 MAP kinase
    • Rubin J, Murphy TC, Zhu L, Roy E, Nanes MS, Fan X. 2003. Mechanical strain differentially regulates eNOS and RANKL expression via ERK1/2 MAP kinase. J Biol Chem 278:34018-34025.
    • (2003) J Biol Chem , vol.278 , pp. 34018-34025
    • Rubin, J.1    Murphy, T.C.2    Zhu, L.3    Roy, E.4    Nanes, M.S.5    Fan, X.6
  • 56
    • 0032101214 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: From basic studies to clinical approaches
    • Sakou T. 1998. Bone morphogenetic proteins: From basic studies to clinical approaches. Bone 22:591-603.
    • (1998) Bone , vol.22 , pp. 591-603
    • Sakou, T.1
  • 57
    • 0032970328 scopus 로고    scopus 로고
    • Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis
    • Sato M, Ochi T, Nakase T, Hirota S, Kitamura Y, Nomura S, Yasui N. 1999. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Miner Res 14:1084-1095.
    • (1999) J Bone Miner Res , vol.14 , pp. 1084-1095
    • Sato, M.1    Ochi, T.2    Nakase, T.3    Hirota, S.4    Kitamura, Y.5    Nomura, S.6    Yasui, N.7
  • 59
    • 0037385687 scopus 로고    scopus 로고
    • Fluid flow-induced prostaglandin E(2) response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium
    • Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, Donahue HJ. 2003. Fluid flow-induced prostaglandin E(2) response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone 32:350-356.
    • (2003) Bone , vol.32 , pp. 350-356
    • Saunders, M.M.1    You, J.2    Zhou, Z.3    Li, Z.4    Yellowley, C.E.5    Kunze, E.L.6    Jacobs, C.R.7    Donahue, H.J.8
  • 62
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • Teitelbaum SL, Ross FP. 2003. Genetic regulation of osteoclast development and function. Nat Rev Genet 4:638-649.
    • (2003) Nat Rev Genet , vol.4 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 63
    • 0034241931 scopus 로고    scopus 로고
    • Invited review: What do we know about the effects of spaceflight on bone?
    • Turner RT. 2000. Invited review: What do we know about the effects of spaceflight on bone? J Appl Physiol 89:840-847.
    • (2000) J Appl Physiol , vol.89 , pp. 840-847
    • Turner, R.T.1
  • 66
    • 0036351099 scopus 로고    scopus 로고
    • ERK activation and alpha v beta 3 integrin signaling through She recruitment in response to mechanical stimulation in human osteoblasts
    • Weyts FA, Li YS, van Leeuwen J, Weinans H, Chien S. 2002. ERK activation and alpha v beta 3 integrin signaling through She recruitment in response to mechanical stimulation in human osteoblasts. J Cell Biochem 87:85-92.
    • (2002) J Cell Biochem , vol.87 , pp. 85-92
    • Weyts, F.A.1    Li, Y.S.2    Van Leeuwen, J.3    Weinans, H.4    Chien, S.5
  • 68
    • 0035918140 scopus 로고    scopus 로고
    • Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts
    • You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. 2001. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem 276:13365-13371.
    • (2001) J Biol Chem , vol.276 , pp. 13365-13371
    • You, J.1    Reilly, G.C.2    Zhen, X.3    Yellowley, C.E.4    Chen, Q.5    Donahue, H.J.6    Jacobs, C.R.7


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