Osteoinductive growth factors in preclinical fracture and long bone defects models

Orthopedic Clinics of North America

Volumn 30, Issue 4, 1999, Pages 647-658

  Bostrom, M P G ^a   Saleh, K J ^a   Einhorn, T A ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; GROWTH HORMONE; NEOSTEO; OSTEOGENIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

BONE DEFECT; BONE GROWTH; BONE PROSTHESIS; COLLAGEN SYNTHESIS; DRUG EFFICACY; FRACTURE; GROWTH STIMULATION; INTRALESIONAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0032822929     PISSN: 00305898     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0030-5898(05)70117-6     Document Type: Article

References (57)

1. B. Bak P.H. Jorgensen T.T. Andreassen Dose response of growth hormone on fracture healing in the rat Acta Orthop Scand 61 1990 54
2. B. Bak P.H. Jorgensen T.T. Andreassen Increased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone Bone 11 1990 233
3. L.S. Beck L. DeGuzman W.P. Lee Transforming growth factor beta 1 bound to tricalcium phosphate persists at segmental radial defects and induces bone formation [abstr] Trans Orthop Res Soc 20 1995 593
4. L.S. Beck L. DeGuzman W.P. Lee Bone marrow augments the activity of transforming growth growth factor beta 1 in critical sized defects [abstr] Trans Orthop Res Soc 21 1996 626
5. L.S. Beck L. DeGuzman L.P. Wyne TGF-beta 1 induces bone closure of skull defects J Bone Min Res 6 1991 1257
6. Y.S. Bland M.A. Critchlow D.E. Ashhurst Exogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit Acta Orthop Scand 66 1995 543
7. M.E. Bolander Regulation of fracture repair by growth factors Proc Soc Exp Biol Med 200 1992 165
8. M.P.G. Bostrom N.P. Camacho Potential role of bone morphogenetic proteins in fracture healing Clin Orthop 355S 1998 274
9. M.P.G. Bostrom J.M. Lane W.S. Berberian Immunolocalization and expression of bone morphogenetic protein 2 and 4 in fracture healing J Orthop Res 13 1995 357
10. M.P.G. Bostrom J.M. Lane E. Tomin The use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model Clin Orthop 327 1996 272
11. W.T. Bourque M. Gross B.K. Hall Expression of four growth factors during fracture repair Int J Dev Biol 37 1993 573
12. J.E. Carpenter J.A. Hipp T.N. Gerhart Failure of growth hormone to alter the biomechanics of fracture-healing in a rabbit model J Bone Joint Surg Am 74 1992 359
13. M. Centrella M.C. Horowitz J.M. Wozney Transforming growth factor-beta gene family members and bone Endocr Rev 15 1994 27
14. Cook, SD: Acceleration of bone healing with OP-1 in a canine noncritical size defect model [abstr]. 2nd International OP-1 Conference, Boston, MA, 1997
15. S.D. Cook G.C. Baffes M.W. Wolfe Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model Clin Orthop 301 1994 302
16. S.D. Cook G.C. Baffes M.W. Wolfe The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects J Bone Joint Surg Am 76 1994 827
17. S.D. Cook M.W. Wolfe S.L. Salkeld Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates J Bone Joint Surg Am 77 1995 734
18. M.A. Critchlow Y.S. Bland D.E. Ashhurst The effect of exogenous transforming growth factor-beta 2 on healing fractures in the rabbit Bone 16 1995 521
19. den Boer FC, Bramer JAM, Blokhius TJ, et al: The effect of recombinant human osteogenic protein-1 on the healing of fresh closed diaphyseal fracture [abstr]. 2nd International OP-1 Conference, Boston, MA, 1997
20. T.A. Einhorn Enhancement of fracture healing Instr Course Lect 45 1996 401
21. Einhorn TA, Majeska RJ, Oloumi G, et al: Enhancement of experimental fracture healing with a local percutaneous injection of rhBMP-2 [abstr]. American Academy of Orthopaedic Surgeons Annual Meeting 1997
22. T.A. Einhorn S.B. Trippel Growth factor treatment of fractures Instr Course Lect 46 1997 483
23. W.H. Harris R.P. Heaney Effect of growth hormone on skeletal mass in adult dog Nature 223 1969 403
24. J.D. Heckman T.B. Aufdemorte K.A. Athanasiou Treatment of acute ostectomy defects in the dog radius with TGF-B1 [abstr] Trans Orthop Res Soc 20 1995 590
25. H.Z. Herold A. Hurvitz A. Tadmur The effect of growth hormone on the healing of experimental bone defects Acta Orthop Scand 42 1971 377
26. S. Jingushi A. Heydemann S.K. Kana Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing J Orthop Res 8 1990 364
27. M.E. Joyce S. Jingushi M.E. Bolander Transforming growth factor-beta in the regulation of fracture repair Orthop Clin North Am 21 1990 199
28. M.E. Joyce R.M. Terek S. Jingushi Role of transforming growth factor-beta in fracture repair Ann NY Acad Sci 593 1990 107
29. C.A. Kirker-Head T.N. Gerhart R. Armstrong Healing bone using recombinant human bone morphogenetic protein 2 and copolymer Clin Orthop 349 1998 205
30. C.A. Kirker-Head T.N. Gerhart S.H. Schelling Long-term healing of bone using recombinant human bone morphogenetic protein 2 Clin Orthop 318 1995 222
31. M. Lind B. Schumacker K. Soballe Transforming growth factor-beta enhances fracture healing in rabbit tibiae Acta Orthop Scand 64 1993 553
32. Matsuishi T: BMP actions of GDF-5. 2nd International Conference of BMPs 2:77, Boston, MA, 1997
33. L. Mosekilde B. Bak The effects of growth hormone on fracture healing in rats: A histological description Bone 14 1993 19
34. F. Nakajima M. Yamazaki A. Ogasawara Enhancement of experimental fracture healing with a local injection of basic fibroblastic growth factor [abstr] Trans Orthop Res Soc 23 1998 596
35. T. Nakamura Y. Hara M. Tagawa Recombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture J Bone Miner Res 13 1998 942
36. T.J. Nash C.R. Howlett C. Martin Effect of platelet-derived growth factor on tibial osteotomies in rabbits Bone 15 1994 203
37. H.M. Nielsen T.T. Andreassen T. Ledet Local injection of TGF-beta increases the strength of tibial fractures in the rat Acta Orthop Scand 65 1994 37
38. M. Noda J.J. Camillier In vivo stimulation of bone formation by transforming growth factor beta Endocrinology 124 1989 2991
39. M.D. Northmore-Ball M.R. Wood B.F. Meggitt A biomechanical study of the effects of growth hormone in experimental fracture healing J Bone Joint Surg Br 62 1980 391
40. T. Onishi Y. Ishidou T. Nagamine Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats Bone 22 1998 605
41. D.L. Peterson T.P. Glancy R. Bacon-Clarke A study of delivery timing and duration of the transforming growth factor beta 1 induced healing of critical-sized long bone defects [abstr] J Bone Min Res 12 1997 S304
42. L.S. Poplich S.L. Salfeld D.C. Rueger Critical and noncritical size defects healing with osteogenic protein-1 [abstr] Trans Orthop Res Soc 22 1997 600
43. M.A. Praemer S. Furner D.P. Rice Musculoskeletal Conditions in the United States 1992 American Academy of Orthopaedic Surgeons Park Ridge, ID
44. M.L. Radomsky A.Y. Thompson R.C. Spiro Potential role of fibroblast growth factor in enhancement of fracture healing Clin Orthop 355S 1998 283
45. A.H. Reddi S. Wientroub N. Muthukumaran Biologic principles of bone induction Orthop Clin North Am 18 1987 207
46. R.N. Rosier R.J. O'Keefe D.G. Hicks The potential role of transforming growth factor beta in fracture healing Clin Orthop 355S 1998 294
47. T. Sakou Bone morphogenetic proteins: From basic studies to clinical approaches Bone 22 1998 591
48. M.M. Sandberg H.T. Aro E.I. Vuorio Gene expression during bone repair Clin Orthop 289 1993 292
49. M.F. Sciadini J.M. Dawson L.M. Berman Dose-response characteristics of recombinant human bone morphogenetic protein-2 in a canine segmental defect model Trans Orthop Res Soc 20 1995 594
50. M.F. Sciadini J.M. Dawson K.D. Johnson Bovine-derived bone protein as a bone graft substitute in a canine segmental defect model J Orthop Trauma 11 1997 496
51. M.F. Sciadini J.M. Dawson K.D. Johnson Evaluation of bovine-derived bone protein with a natural coral carrier as a bone-graft substitute in a canine segmental defect model J Orthop Res 15 1997 844
52. D.J. Simmons Fracture healing perspectives Clin Orthop 200 1985 101
53. S.B. Trippel Potential role of insulinelike growth factors in fracture healing Clin Orthop 355S 1998 301
54. T. Turek M.P.G. Bostrom N.P. Camacho The acceleration of fracture healing in a rabbit ulnar osteotomy model with bone morphogenetic protein 2 [abstr] Trans Orthop Res Soc 22 1997 526
55. M.R. Urist Bone: Formation by autoinduction Science 150 1965 893
56. A.W. Yasko J.M. Lane E.J. Fellinger The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): A radiographic, histological, and biomechanical study in rats [published erratum appears in J Bone Joint Surg Am 1992 Aug; 74(7): 1111] J Bone Joint Surg Am 74 1992 659
57. R.E. Zadek R.A. Robinson The effect of growth hormone of healing of experimental long-bone defect J Bone Joint Surg Am 43 1961 1261