Synthesis and Structure-Activity Relationships of 4-Cycloalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one Derivatives as A 1 and A3 Adenosine Receptor Antagonists

Archiv der Pharmazie

Volumn 337, Issue 1, 2004, Pages 35-41

  Colotta, Vittoria ^a   Catarzi, Daniela ^a   Varano, Flavia ^a   Filacchioni, Guido ^a   Martini, Claudia ^b   Trincavelli, Letizia ^b   Lucacchini, Antonio ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Adenosine receptor antagonists; G Protein coupled receptors; Triazoloquinoxalines; Tricyclic heteroaromatic systems

Indexed keywords

4 CYCLOHEXYLAMINE DERIVATIVE; 4 CYCLOHEXYLAMINO 1,2 DIHYDRO 6 NITRO 2 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 6,8 DICHLORO 4 CYCLOHEXYLAMINO 1,2 DIHYDRO 2 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 7,8 DICHLORO 4 CYCLOHEXYLAMINO 1,2 DIHYDRO 2 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; 8 CHLORO 4 CYCLOHEXYLAMINO 1,2 DIHYDRO 6 NITRO 2 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALIN 1 ONE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; BENZENE; FUNCTIONAL GROUP; G PROTEIN COUPLED RECEPTOR; QUINOXALINE DERIVATIVE; TRIAZOLE DERIVATIVE; TRICYCLIC AROMATIC COMPOUND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATTLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ALKANES; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATTLE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; HUMANS; IODINE ISOTOPES; MEMBRANES; NEOSTRIATUM; PHENETHYLAMINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOXALINES; RECEPTORS, PURINERGIC; TRIAZOLES; TRITIUM;

EID: 1242291917     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200300816     Document Type: Article

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