Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma

Gut

Volumn 54, Issue 1, 2005, Pages 103-108

  Wright, C M ^a,b   Dent, O F ^c   Newland, R C ^c   Barker, M ^b   Chapuis, P H ^c   Bokey, E L ^c   Young, J P ^b   Leggett, B A ^b   Jass, J R ^d   Macdonald, G A ^d  

^a Suite 304   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA, NEOPLASM; FEMALE; GENOMIC INSTABILITY; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 19944374437     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.034579     Document Type: Article

References (46)

1. Australian Institute of Health and Welfare and the Australasian Association of Cancer Registries. Cancer in Australia 1995: Incidence and mortality data for 1995 and selected data for 1990. Cancer Series 10 (cat. no. CAN 5). Canberra: Australian Institute of Health and Welfare, 1998.
2. Chapuis PH, Dent OH, Fisher R, et al. A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer. Br J Surg 1985;72:698-702.
3. Newland RC, Chapuis PH, Smyth ER. The prognostic value of substaging colorectal carcinoma. A prospective study of 1117 cases with standardised pathology. Cancer 1987;60:852-7.
4. Boland CR. Roles of the DNA mismatch repair genes in colorectal tumorigenesis. Int J Cancer 1996;69:47-9.
5. Eshleman JR, Morkowitz SD. Mismatch repair defects in human carcinogenesis. Hum Mol Genet 1996;5:1489-94.
6. Boland RC, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-7.
7. Parsons R, Myeroff LL, Lui B, et al. Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res 1995;55:5548-50.
8. Souza RF, Appel R, Yin J, et al. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet 1996;14:255-7.
9. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-19.
10. Peltomaki P, Aaltonen LA, Sistonen P, et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science 1993;260:810-12.
11. Aaltonen LA, Peltomaki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993;260:812-16.
12. Ionov Y, Peinado MA, Malkhosyan S, et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993;363:558-61.
13. Sankila R, Aaltonen LA, Jarvinen HJ, et al. Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology 1996;110:682-7.
14. Kim H, Jen J, Vogelstein B, et al. Clinical and pathological characteristics of sparadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:148-56.
15. Risio M, Reato G, di Celle PF, et al. Microsatellite instability is associated with the histological features of the tumour in nonfamilial colorectal cancer. Cancer Res 1996;56:5470-4.
16. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hLMH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998;95:6870-5.
17. Haydon AM, Jass JR. Emerging pathways in colorectal-cancer development. Lancet Oncol 2002;3:83-8.
18. Wright CM, Dent OF, Barker M, et al. Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg 2000;87:1197-202.
19. Halling KC, French AJ, McDonnell SK, et al. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal Cancers. J Natl Cancer Inst 1999;15:1295-303.
20. Ward R, Meagher A, Tomlinson I, et al. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut 2001;48:821-9.
21. Samowitz WS, Curtin K, Ma KN, et al. Microsatellite instability in sporadic colon cancer is associated is associated with an improved prognosis at the population level. Cancer Epidemiol Biomarkers Prev 2001;10:917-23.
22. Tomlinson I, Halford S, Aaltonen L, et al. Does MSI-low exist? J Pathol 2002;197:6-13.
23. Laiho P, Launonen V, Lahermo P, et al. Low-level microsatellite instability in most colorectal carcinomas. Cancer Res 2002;62:1166-70.
24. Halford S, Sasieni P, Rowan A, et al. Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. Cancer Res 2002;62:53-7.
25. Halford SER, Sawyer EJ, Lambros MB, et al. MSI-low, a real phenomenon which varies in frequency among cancer types. J Pathol 2003;201:389-94.
26. Guda K, Upender MB, Belinsky G, et al. Carcinogen-induced colon tumors in mice are chromosomally stable and are characterised by low-level microsatellite instability. Oncogene 2004;23:3813-21.
27. Whitehall VL, Walsh MD, Young J, et al. Methylation of O-6-methylquanine DMA methytransferase characterises a subset of colorectal cancer with low level DNA microsatellite instability. Cancer Res 2001;61:827-30.
28. Jass JR, Biden KG, Cummimgs MC, et al. Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator phenotype. J Clin Pathol 1999;52:455-60.
29. Mori Y, Selaru F, Sato S, et al. The impact of microsatellite instability on the molecular phenotype of colorectal tumors. Cancer Res 2003;63:4577-82.
30. Fielding LP, Arsenault PA, Chapuis PH, et al. Clinicopathological staging for colorectal cancer: an International Documentation System (IDS) and an International Comprehensive Anatomical Terminology (ICAT). J Gastroenterol Hepatol 1991;6:325-44.
31. Levi S, Urbano-Ispizua A, Gill R, et al. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 1991;51:3497-502.
32. Wissenbach J, Gyapay G, Dib C, et al. A second generation linkage map of the human genome. Nature 1992;359:794-801.
33. Spiro L, Joselyn G, Nelson L, et al. A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene. Nucleic Acids Res 1991;19:6348.
34. Weber JL, Kwitek AE, May PE, et al. Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci. Nucleic Acids Res 1990;18:4640.
35. Dib C, Faure S, Fizames C, et al. A comprehensive map of the human genome based on 5,264 microsatellites. Nature 1996;380:152-4.
36. Biden KG, Simms LA, Cummings M, et al. Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability. Oncogene 1998;17:1-5.
37. Makela TP, Hellsten E, Vesa J, et al. An Alu variable polyA repeat polymorphism upstream of L-myc at 1p32. Hum Mol Genet 1992;1:217.
38. Dietmaier W, Wallinger S, Bocker T, et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res 1997;57:4749-56.
39. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. Am Stat Assoc J 1958;53:457-81.
40. SPSS Inc. Statistical package for the social sciences 8.0. Chicago: SPSS Inc, 1998.
41. Newland RC, Dent OF, Lyttle, et al. Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A mutivariate analysis of 579 patients. Cancer 1994;73:2076-82.
42. Whitehall VLJ, Wynter CVA, Walsh MD, et al. Morphological and molecular heterogeneity within nonmicrosastellite instability-high colorectal cancer. Cancer Res 2002;62:6011-14.
43. Tang R, Chanchien CR, Wu MC, et al. Colorectal cancer without high microsatellite instability and chromosomal instability-an alternative genetic pathway to human colorectal cancer. Carcinogenesis 2004;25:841-6.
44. Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003;349:247-57.
45. Jass JR, Whitehall VLJ, Young J, et al. Correspondence re: P Laiho et al. Low-level microsatellite instability in most colorectal carcinomas. Cancer Res 2002;62:1166-70.
46. Hoang JM, Cottu PH, Thiuille B, et al. BAT-26, an indicator of the replication error phenotype in colorectal cancer. Cancer Res 1997;57:300-3.