Attenuated Salmonella and Shigella as carriers for DNA vaccines

Journal of Drug Targeting

Volumn 11, Issue 8-10, 2003, Pages 481-488

  Xu, Feng ^a,b   Ulmer, J B ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NONE   (United States)

Author keywords

Attenuated strains; DNA vaccines; Immune responses; Salmonella; Shigella

Indexed keywords

DNA VACCINE; DRUG CARRIER; HEMAGGLUTININ; INTERLEUKIN 18; INTERLEUKIN 4; MEASLES VACCINE; NAKED DNA; PLASMID DNA; RECOMBINANT INTERLEUKIN 2; TETANUS TOXIN;

ANTIBIOTIC RESISTANCE; ANTIBODY RESPONSE; BACTERIAL GENE DELIVERY SYSTEM; BACTERIAL STRAIN; DNA TRANSFER; DNA VECTOR; DRUG POTENCY; EXPERIMENTAL MODEL; GENE DELIVERY SYSTEM; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW; SALMONELLA; SALMONELLA TYPHI; SALMONELLA TYPHIMURIUM; SHIGELLA; TETANUS;

ANIMALS; BACTERIAL VACCINES; HUMANS; SALMONELLA; SHIGELLA; VACCINES, ATTENUATED; VACCINES, DNA;

EID: 1942475340     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860410001670053     Document Type: Review

References (86)

1. al-Ramadi, B.K., Adeghate, E., Mustafa, N., Ponery, A.S. and Fernandez-Cabezudo, M.J. (2002) "Cytokine expression by attenuated intracellular bacteria regulates the immune response to infection: the Salmonella model", Mol. Immunol. 38, 931-940.
2. Anderson, R.J., Pasetti, M.F., Sztein, M.B., Levine, M.M. and Noriega, F.R. (2000) "ΔguaBA attenuated Shigella flexneri 2a strain CVD 1204 as a Shigella vaccine and as a live mucosal delivery system for fragment C of tetanus toxin", Vaccine 18, 2193-2202.
3. Attridge, S.R., Davies, R. and LaBrooy, J.T. (1997) "Oral delivery of foreign antigens by attenuated Salmonella: consequences of prior exposure to the vector strain", Vaccine 15, 155-162.
4. Bao, J.X. and Clements, J.D. (1991) "Prior immunologic experience potentiates the subsequent antibody response when Salmonella strains are used as vaccine carriers", Infect. Immun. 59, 3841-3845.
5. Barthel, M., Hapfelmeier, S., Quintanilla-Martinez, L., Kremer, M., Rohde, M., Hogardt, M., Pfeffer, K., Russmann, H. and Hardt, W.D. (2003) "Pretreatment of mice with streptomycin provides a Salmonella enterica serovar typhimurium colitis model that allows analysis of both pathogen and host", Infect. Immun. 71, 2839-2858.
6. Berglund, P., Smerdou, C., Fleeton, M.N., Tubulekas, I. and Liljestrom, P. (1998) "Enhancing immune responses using suicidal DNA vaccines", Nat. Biotechnol. 16, 562-565.
7. Berzofsky, J.A., Ahlers, J.D., Derby, M.A., Pendleton, C.D., Arichi, T. and Belyakov, I.M. (1999) "Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections", Immunol. Rev. 170, 151-172.
8. Brunham, R.C. and Zhang, D. (1999) "Transgene as vaccine for Chlamydia", Am. Heart J. 138, S519-S522.
9. Chatfield, S.N., Strahan, K., Pickard, D., Charles, I.G., Hormaeche, C.E. and Dougan, G. (1992) "Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model", Microb. Pathog. 12, 145-151.
10. Chatfield, S., Roberts, M., Li, J., Starns, A. and Dougan, G. (1994) "The use of live attenuated Salmonella for oral vaccination", Dev. Biol. Stand. 82, 35-42.
11. Cicin-Sain, L., Brune, W., Bubic, I., Jonjic, S. and Koszinowski, U.H. (2003) "Vaccination of mice with bacteria carrying a cloned herpesvirus genome reconstituted in vivo", J. Virol. 77, 8249-8255.
12. Cochlovius, B., Stassar, M.J., Schreurs, M.W., Benner, A. and Adema, G.J. (2002) "Oral DNA vaccination: antigen uptake and presentation by dendritic cells elicits protective immunity", Immunol. Lett. 80, 89-96.
13. Covone, M.G., Brocchi, M., Palla, E., Dias da Silveira, W., Rappuoli, R. and Galeotti, C.L. (1998) "Levels of expression and immunogenicity of attenuated Salmonella enterica serovar typhimurium strains expressing Escherichia coli mutant heat-labile enterotoxin", Infect. Immun. 66, 224-231.
14. Darji, A., zur Lage, S., Garbe, A.I., Chakraborty, T. and Weiss, S. (2000) "Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier", FEMS Immunol. Med. Microbiol. 27, 341-349.
15. Devico, A.L., Fouts, T.R., Shata, M.T., Kamin-Lewis, R., Lewis, G.K. and Hone, D.M. (2002) "Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1", Vaccine 20, 1968-1974.
16. Dietrich, G., Bubert, A., Gentschev, I., Sokolovic, Z., Simm, A., Catic, A., Kaufmann, S.H., Hess, J., Szalay, A.A. and Goebel, W. (1998) "Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes", Nat. Biotechnol. 16, 181-185.
17. Donnelly, J.J., Ulmer, J.B. and Liu, M.A. (1997) "DNA vaccines", Life Sci. 60, 163-172.
18. Elias, F. and Flo, J. (2002) "Modulation of the immune response mediated by oral transgene administration of IL-10", Cell Immunol. 216, 73-81.
19. Fairweather, N.F., Chatfield, S.N., Charles, I.G., Roberts, M., Lipscombe, M., Li, L.J., Strugnell, D., Comerford, S., Tite, J. and Dougan, G. (1990) "Use of live attenuated bacteria to stimulate immunity", Res. Microbiol. 141, 769-773.
20. Fennelly, G.J., Khan, S.A., Abadi, M.A., Wild, T.F. and Bloom, B.R. (1999) "Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector", J. Immunol. 162, 1603-1610.
21. Fernandez, M.I., Thuizat, A., Pedron, T., Neutra, M., Phalipon, A. and Sansonetti, P.J. (2003) "A newborn mouse model for the study of intestinal pathogenesis of shigellosis", Cell Microbiol. 5, 481-491.
22. Flo, J., Tisminetzky, S. and Baralle, F. (2001) "Oral transgene vaccination mediated by attenuated Salmonellae is an effective method to prevent Herpes simplex virus-2 induced disease in mice", Vaccine 19, 1772-1782.
23. Fouts, T.R., Tuskan, R.G., Chada, S., Hone, D.M. and Lewis, G.K. (1995) "Construction and immunogenicity of Salmonella typhimurium vaccine vectors that express HIV-1 gp120", Vaccine 13, 1697-1705.
24. Galan, J.E. and Curtiss, 3rd, R. (1989) "Virulence and vaccine potential of phoP mutants of Salmonella typhimurium", Microb. Pathog. 6, 433-443.
25. Galan, J.E., Nakayama, K. and Curtiss, 3rd, R. (1990) "Cloning and characterization of the asd gene of Salmonella typhimurium: use in stable maintenance of recombinant plasmids in Salmonella vaccine strains", Gene 94, 29-35.
26. Garcia-del Portillo, F. and Finlay, B.B. (1995) "The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments", Trends Microbiol. 3, 373-380.
27. Gentschev, I., Mollenkopf, H., Sokolovic, Z., Hess, J., Kaufmann, S.H. and Goebel, W. (1996) "Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway", Gene 179, 133-140.
28. Gentschev, I., Glaser, I., Goebel, W., McKeever, D.J., Musoke, A. and Heussler, V.T. (1998) "Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: secretion of the product enhances specific antibody responses in cattle", Infect. Immun. 66, 2060-2064.
29. Gentschev, I., Dietrich, G., Spreng, S., Kolb-Maurer, A., Brinkmann, V., Grode, L., Hess, J., Kaufmann, S.H. and Goebel, W. (2001) "Recombinant attenuated bacteria for the delivery of subunit vaccines", Vaccine 19, 2621-2628.
30. Grillot-Courvalin, C., Goussard, S., Huetz, F., Ojcius, D.M. and Courvalin, P. (1998) "Functional gene transfer from intracellular bacteria to mammalian cells", Nat. Biotechnol. 16, 862-866.
31. Grillot-Courvalin, C., Goussard, S. and Courvalin, P. (2002) "Wild-type intracellular bacteria deliver DNA into mammalian cells", Cell Microbiol. 4, 177-186.
32. Gurunathan, S., Klinman, D.M. and Seder, R.A. (2000) "DNA vaccines: immunology, application, and optimization", Annu. Rev. Immunol. 18, 927-974.
33. Hantman, M.J., Hohmann, E.L., Murphy, C.G., Knipe, D.M. and Miller, S.I. (1999) "Antigen Delivery Systems: development of recombinant live vaccines using viral or bacterial vectors", In: Ogra, P.L., Mestecky, J., Lamm, M.E., Strober, W., Bienenstrock, J. and McGhee, J.R., eds, Mucosal Immunology, 2nd Ed. (Academic Press, San Diego), pp 779-791.
34. Hess, J., Gentschev, I., Miko, D., Welzel, M., Ladel, C., Goebel, W. and Kaufmann, S.H. (1996) "Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis", Proc. Natl Acad. Sci. USA 93, 1458-1463.
35. Hoiseth, S.K. and Stocker, B.A. (1981) "Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines", Nature 291, 238-239.
36. Hume, P.J., McGhie, E.J., Hayward, R.D. and Koronakis, V. (2003) "The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology", Mol. Microbiol. 49, 425-439.
37. Jain, V. and Mekalanos, J.J. (2000) "Use of lambda phage S and R gene products in an inducible lysis system for Vibrio cholerae- and Salmonella enterica serovar typhimurium-based DNA vaccine delivery systems", Infect. Immun. 68, 986-989.
38. Janeway, Jr., C.A. and Medzhitov, R. (2002) "Innate immune recognition", Annu. Rev. Immunol. 20, 197-216.
39. Kang, H.Y., Srinivasan, J. and Curtiss, 3rd, R. (2002) "Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated Salmonella enterica serovar typhimurium vaccine", Infect. Immun. 70, 1739-1749.
40. Lee, J.J., Sinha, K.A., Harrison, J.A., de Hormaeche, R.D., Riveau, G., Pierce, R.J., Capron, A., Wilson, R.A. and Khan, C.M. (2000) "Tetanus toxin fragment C expressed in live Salmonella vaccines enhances antibody responses to its fusion partner Schistosoma haematobium glutathione S-transferase", Infect. Immun. 68, 2503-2512.
41. Lehner, T., Wang, Y., Ping, L., Bergmeier, L., Mitchell, E., Cranage, M., Hall, G., Dennis, M., Cook, N., Doyle, C. and Jones, I. (1999) "The effect of route of immunization on mucosal immunity and protection", J. Infect. Dis. 179, S489-S492.
42. Lode, H.N., Pertl, U., Xiang, R., Gaedicke, G. and Reisfeld, R.A. (2000) "Tyrosine hydroxylase-based DNA-vaccination is effective against murine neuroblastoma", Med. Pediatr. Oncol. 35, 641-646.
43. Luo, Y., Zhou, H., Mizutani, M., Mizutani, N., Reisfeld, R.A. and Xiang, R. (2003) "Transcription factor Fos-related antigen 1 is an effective target for a breast cancer vaccine", Proc. Natl Acad. Sci. USA 100, 8850-8855.
44. Maloy, K.J., Erdmann, I., Basch, V., Sierro, S., Kramps, T.A., Zinkernagel, R.M., Oehen, S. and Kundig, T.M. (2001) "Intralymphatic immunization enhances DNA vaccination", Proc. Natl Acad. Sci. USA 98, 3299-3303.
45. McNeill, H.V., Sinha, K.A., Hormaeche, C.E., Lee, J.J. and Khan, C.M. (2000) "Development of a nonantibiotic dominant marker for positively selecting expression plasmids in multivalent Salmonella vaccines", Appl. Environ. Microbiol. 66, 1216-1219.
46. Miller, I., Maskell, D., Hormaeche, C., Johnson, K., Pickard, D. and Dougan, G. (1989) "Isolation of orally attenuated Salmonella typhimurium following TnphoA mutagenesis", Infect. Immun. 57, 2758-2763.
47. Miller, S.I., Mekalanos, J.J. and Pulkkinen, W.S. (1990) "Salmonella vaccines with mutations in the phoP virulence regulon", Res. Microbiol. 141, 817-821.
48. Mollenkopf, H.J., Groine-Triebkorn, D., Andersen, P., Hess, J. and Kaufmann, S.H. (2001) "Protective efficacy against tuberculosis of ESAT-6 secreted by a live Salmonella typhimurium vaccine carrier strain and expressed by naked DNA", Vaccine 19, 4028-4035.
49. + expression-cloning vector: Stable maintenance and high level expression of cloned genes in a Salmonella vaccine strain", Biotechnology (NY) 6, 693-697.
50. Nataro, J.P. and Levine, M.M. (1999) "Enteric Bacterial Vaccines: Salmonella, Shigella, Cholera, Escherichia coli", In: Ogra, P.L., Mestecky, J., Lamm, M.E., Strober, W., Bienenstock, J. and McGhee, J.R., eds, Mucosal Immunology, 2nd Ed. (Academic Press, San Diego), pp 851-865.
51. Neutra, M.R., Frey, A. and Kraehenbuhl, J.P. (1996) "Epithelial M cells: gateways for mucosal infection and immunization", Cell 86, 345-348.
52. Niethammer, A.G., Primus, F.J., Xiang, R., Dolman, C.S., Ruehlmann, J.M., Ba, Y., Gillies, S.D. and Reisfeld, R.A. (2001a) " An oral DNA vaccine against human carcinoembryonic antigen (CEA) prevents growth and dissemination of Lewis lung carcinoma in CEA transgenic mice", Vaccine 20, 421-429.
53. Niethammer, A.G., Xiang, R., Ruehlmann, J.M., Lode, H.N., Dolman, C.S., Gillies, S.D. and Reisfeld, R.A. (2001b) "Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma", Cancer Res. 61, 6178-6184.
54. Noriega, F.R., Losonsky, G., Lauderbaugh, C., Liao, F.M., Wang, J.Y. and Levine, M.M. (1996) "Engineered ΔguaB-A Δ virG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine", Infect. Immun. 64, 3055-3061.
55. O'Callaghan, D., Maskell, D., Liew, F.Y., Easmon, C.S. and Dougan, G. (1988) "Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice", Infect. Immun. 56, 419-423.
56. Paglia, P., Medina, E., Arioli, I., Guzman, C.A. and Colombo, M.P. (1998) "Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma", Blood 92, 3172-3176.
57. Pasetti, M.F., Anderson, R.J., Noriega, F.R., Levine, M.M. and Sztein, M.B. (1999) "Attenuated ΔguaBA Salmonella typhi vaccine strain CVD 915 as a live vector utilizing prokaryotic or eukaryotic expression systems to deliver foreign antigens and elicit immune responses", Clin. Immunol. 92, 76-89.
58. Pasetti, M.F., Barry, E.M., Losonsky, G., Singh, M., Medina-Moreno, S.M., Polo, J.M., Ulmer, J., Robinson, H., Sztein, M.B. and Levine, M.M. (2003) "Attenuated Salmonella enterica serovar typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats", J. Virol. 77, 5209-5217.
59. Pertl, U., Wodrich, H., Ruehlmann, J.M., Gillies, S.D., Lode, H.N. and Reisfeld, R.A. (2003) "Immunotherapy with a posttranscriptionally modified DNA vaccine induces complete protection against metastatic neuroblastoma", Blood 101, 649-654.
60. Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P. and Ricciardi-Castagnoli, P. (2001) "Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria", Nat. Immunol. 2, 361-367.
61. Roberts, M., Bacon, A., Li, J. and Chatfield, S. (1999) "Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C", Infect. Immun. 67, 3810-3815.
62. Rosenkranz, C.D., Chiara, D., Agorio, C., Baz, A., Pasetti, M.F., Schreiber, F., Dematteis, S., Martinez, M., Sztein, M.B. and Chabalgoity, J.A. (2003) "Towards new immunotherapies: targeting recombinant cytokines to the immune system using live attenuated Salmonella", Vaccine 21, 798-801.
63. Sansonetti, P. (2001) "Phagocytosis of bacterial pathogens: implications in the host response", Semin. Immunol. 13, 381-390.
64. Sansonetti, P. (2002) "Host-pathogen interactions: the seduction of molecular cross talk", Gut 50(Suppl. 3), III 2-III 8.
65. Schaffner, W. (1980) "Direct transfer of cloned genes from bacteria to mammalian cells", Proc. Natl Acad. Sci. USA 77, 2163-2167.
66. + T cells and antiviral protective immunity", J. Virol. 75, 9665-9670.
67. + T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector", Vaccine 20, 623-629.
68. Siebers, A. and Finlay, B.B. (1996) "M cells and the pathogenesis of mucosal and systemic infections", Trends Microbiol. 4, 22-29.
69. Sizemore, D.R., Branstrom, A.A. and Sadoff, J.C. (1995) "Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization", Science 270, 299-302.
70. Stocker, B.A. and Newton, S.M. (1994) "Immune responses to epitopes inserted in Salmonella flagellin", Int. Rev. Immunol. 11, 167-178.
71. Takeuchi, A. (1967) "Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium", Am. J. Pathol. 50, 109-136.
72. Tsolis, R.M., Kingsley, R.A., Townsend, S.M., Ficht, T.A., Adams, L.G. and Baumler, A.J. (1999) "Of mice, calves, and men. Comparison of the mouse typhoid model with other Salmonella infections", Adv. Exp. Med. Biol. 473, 261-274.
73. +-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection", Infect. Immun. 70, 153-162.
74. Vazquez-Torres, A., Jones-Carson, J., Baumler, A.J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W.T. and Fang, F.C. (1999) "Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes", Nature 401, 804-808.
75. Vecino, W.H., Morin, P.M., Agha, R., Jacobs, Jr., W.R. and Fennelly, G.J. (2002) "Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV", Immunol. Lett. 82, 197-204.
76. Wallis, T.S. and Galyov, E.E. (2000) "Molecular basis of Salmonella-induced enteritis", Mol. Microbiol. 36, 997-1005.
77. Wedemeyer, H., Gagneten, S., Davis, A., Bartenschlager, R., Feinstone, S. and Rehermann, B. (2001) "Oral immunization with HCV-NS3-transformed Salmonella: induction of HCV-specific CTL in a transgenic mouse model", Gastroenterology 121, 1158-1166.
78. Weth, R., Christ, O., Stevanovic, S. and Zoller, M. (2001) "Gene delivery by attenuated Salmonella typhimurium: comparing the efficacy of helper versus cytotoxic T cell priming in tumor vaccination", Cancer Gene Ther. 8, 599-611.
79. Whittle, B.L. and Verma, N.K. (1997) "The immune response to a B-cell epitope delivered by Salmonella is enhanced by prior immunological experience", Vaccine 15, 1737-1740.
80. Wong, L.P., Woo, P.C., Wu, A.Y. and Yuen, K.Y. (2002) "DNA immunization using a secreted cell wall antigen Mp1p is protective against Penicillium marneffei infection", Vaccine 20, 2878-2886.
81. Woo, P.C., Wong, L.P., Zheng, B.J. and Yuen, K.Y. (2001) "Unique immunogenicity of hepatitis B virus DNA vaccine presented by live-attenuated Salmonella typhimurium", Vaccine 19, 2945-2954.
82. Xiang, R., Lode, H.N., Chao, T.H., Ruehlmann, J.M., Dolman, C.S., Rodriguez, F., Whitton, J.L., Overwijk, W.W., Restifo, N.P. and Reisfeld, R.A. (2000) "An autologous oral DNA vaccine protects against murine melanoma", Proc. Natl Acad. Sci. USA 97, 5492-5497.
83. Xiang, R., Primus, F.J., Ruehlmann, J.M., Niethammer, A.G., Silletti, S., Lode, H.N., Dolman, C.S., Gillies, S.D. and Reisfeld, R.A. (2001a) "A dual-function DNA vaccine encoding carcinoembryonic antigen and CD40 ligand trimer induces T cell-mediated protective immunity against colon cancer in carcinoembryonic antigen-transgenic mice", J. Immunol. 167, 4560-4565.
84. Xiang, R., Silletti, S., Lode, H.N., Dolman, C.S., Ruehlmann, J.M., Niethammer, A.G., Pertl, U., Gillies, S.D., Primus, F.J. and Reisfeld, R.A. (2001b) "Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice", Clin. Cancer Res. 7, 856s-864s.
85. Xu, F., Hong, M. and Ulmer, J.B. (2003) "Immunogenicity of an HIV-1 gag DNA vaccine carried by attenuated Shigella", Vaccine 21, 644-648.
86. Zoller, M. and Christ, O. (2001) "Prophylactic tumor vaccination: comparison of effector mechanisms initiated by protein versus DNA vaccination", J. Immunol. 166, 3440-3450.