Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine

Cancer Research

Volumn 61, Issue 22, 2001, Pages 8171-8178

  Albini, Adriana ^a   Morini, Monica ^a   D'Agostini, Francesco ^b   Ferrari, Nicoletta ^a   Campelli, Francesco ^a   Arena, Giuseppe ^a   Noonan, Douglas M ^a   Pesce, Carlo ^b   De Flora, Silvio ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CYCLINE; GELATINASE A; KI 67 ANTIGEN; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GROWTH INHIBITION; KAPOSI SARCOMA; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

ACETYLCYSTEINE; ADMINISTRATION, ORAL; ANGIOGENESIS INHIBITORS; ANIMALS; CELL DIVISION; CELL MOVEMENT; ENDOTHELIAL GROWTH FACTORS; FEMALE; GROWTH INHIBITORS; HUMANS; KI-67 ANTIGEN; LYMPHOKINES; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA, MESSENGER; SARCOMA, KAPOSI; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035890541     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. The role of angiogenesis in tumor growth
2. Angiogenesis in cancer, vascular, rheumatoid and other disease
3. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
4. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
5. Molecular and biological properties of vascular endothelial growth factor
6. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
7. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
8. Epstein-Barr virus and Kaposi's sarcoma berpesvirus/human herpesvirus 8
9. Kaposi's sarcoma-associated herpesvirus
10. A review of Kaposi's sarcoma
11. Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness
12. Assessment of angiogenic potential - The use of AIDS-KS cells supernatants as an in vitro model
13. Characterization of Kaposi's sarcoma-derived cell cultures from an epidemic and a classic case
14. Angiogenic potential in vivo by Kaposi sarcoma cell-free supematants and HIV 1-tat product: Inhibition of KS-like lesions by TIMP-2
15. Mechanisms of Kaposi's sarcoma cell supematant-induced vascular cell invasion
16. The β-core fragment of human chorionic gonadotrophin (hCG) inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line
17. Kaposi's sarcoma cells of different etiologic origins respond to HIV-Tat through the Flk-KDR (VEGFR-2): Relevance in AIDS-KS pathology
18. Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells
19. Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells
20. c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro
21. Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis
22. Clinical development plans for cancer chemopreventive agents: N-acetyl-L-cysteine
23. Mechanism of anticarcinogenesis: The example of N-acetylcysteine
24. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
25. Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine
26. N-Acetyl cysteine inhibits endothelial cell invasion and angiogenesis
27. A rapid in vitro assay for quantitating the invasive potential of tumor cells
28. Tumor and endothelial cell invasion of basement membranes
29. The α3β1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity
30. Effects of angiostatin gene transfer on functional properties and in vivo growth of Kaposi's sarcoma cells
31. Chemopreventive properties and mechanisms of N-acetylcysteine. The experimental background
32. Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models
33. Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice
34. The activation of human type IV collagenase proenzyme
35. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells, N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade
36. Intracellular glutathione levels regulate fos/jun induction and activation of glutathione S-transferase gene expression
37. p53-independent inhibition of proliferation and p21(WAFI/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E
38. Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells
39. κB activation and protects against alloxan-induced diabetes in CD-1 mice
40. Diethyldithiocarbamate enhances production of nitric oxide and TNF-α by lipopolysaccharide-stimulated rat Kupffer cells
41. Biphasic effect of UVA radiation on STATI activity and tyrosine phosphorylation in cultured human keratinocytes
42. κB kinases
43. The pathway regulating GADD153 induction in response to DNA damage is independent of protein kinase C and tyrosine kinases
44. Epidermal growth factor receptor is modulated by redox through multiple mechanisms. Effects of reductants and H202
45. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element
46. Induction of cyclin-dependent kinase inhibitors and G(I) prolongation by the chemopreventive agent N-acetylcysteine. Carcinogenesis (Lond.)
47. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
48. Biomedicine. Protein loss in cancer cachexia
49. Recombinant thrombomodulin inhibits thrombin-induced vascular endothelial growth factor production in neuronal cells
50. Vascular endothelial growth factor (VEGF) and melanoma. N-Acetylcysteine downregulates VEGF production in vitro
51. Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo
52. 2 sensing
53. Upregulation of vascular endothelial growth factor by H202 in rat heart endothelial cells
54. Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts
55. Antiapoptotic and antigenotoxic effects of N-acetylcysteine in human cells of endothelial origin
56. Pharmacokinetic and pharmacodynamic studies of N-acetylcysteine, a potential chemopreventive agent during a Phase I trial
57. Long-term efficacy on Kaposi's sarcoma of highly active antiretroviral therapy in a cohort of HIV-positive patients
58. Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: Biological correlates of clinical outcome
59. Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma
60. HAART is effective as anti-Kaposi's sarcoma therapy only after remission has been induced by chemotherapy
61. N-Acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells
62. Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication
63. Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone