Predominance of Type 1 cytokines and decreased number of CD4 +CD25+ high T regulatory cells in peripheral blood of patients with recurrent aphthous ulcerations

Immunology Letters

Volumn 99, Issue 1, 2005, Pages 57-62

  Lewkowicz, Natalia ^a   Lewkowicz, Przemysław ^b   Banasik, Małgorzata ^b   Kurnatowska, Anna ^a   Tchórzewski, Henryk ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

Author keywords

CD4 +CD25+ T regulatory cells; Recurrent aphthous ulcerations; Th1 Th2 cytokines; Tolerance

Indexed keywords

CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; APHTHOUS ULCER; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE DEFICIENCY; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; LYMPHOCYTE COUNT; MALE; MICROBIAL COLONIZATION; MOUTH MUCOSA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RECURRENT DISEASE; REMISSION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ADULT; CYTOKINES; FEMALE; HUMANS; INFLAMMATION; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROTEINS; RECEPTORS, INTERLEUKIN-2; STOMATITIS, APHTHOUS; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 19344374086     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.01.002     Document Type: Article

References (27)

1. C. Scully, M. Gorsky, and F. Lozada-Nur The diagnosis and management of recurrent aphthous stomatitis: a consensus approach J Am Dent Assoc 134 2003 200 207
2. E.A. Graykowski, M.F. Barile, W.B. Lee, and H.R. Tanley Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic and hypersensitivity aspects J Am Med Assoc 196 1966 637 644
3. T. Lehner Autoimmunity in oral diseases, with special reference to recurrent oral ulceration Proc R Soc Med 61 1968 515 524
4. A. Hasan Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers Clin Exp Immunol 99 1995 392 397
5. A. Hasan, T. Shinnick, V. Mizushima, R. Van der Zee, and T. Lehner Defining a T-cell epitope within HSP 65 in recurrent aphthous stomatitis Clin Exp Immunol 128 2002 318 325
6. A. Sun, J.S. Chia, and C.P. Chiang Increased proliferative response of peripheral blood mononuclear cells and T cells to Streptococcus mutans and glucosylotransferase D antigens in the exacerbation stage of recurrent aphthous ulcerations J Formos Med Assoc 101 2002 560 566
7. A. Davidson, and B. Diamond Autoimmune diseases N Engl J Med 345 2001 340 350
8. D. Nemazee Receptor selection in B and T lymphocytes Annu Rev Immunol 18 2000 19 31
9. I.R. Mackay, and F.S. Rosen Tolerance and autoimmunity N Engl J Med 344 2001 655 664
10. H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, and A.H. Enk Identification and functional characterizaion of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood J Exp Med 193 2001 1285 1294
11. D. Dieckman, H. Plottner, S. Berchtold, T. Berger, and G. Schuler Ex vivo isolation and characterizaion of CD4+CD25+ T cells with regulatory properties from human blood J Exp Med 193 2001 1303 1310
12. M.K. Levings, R. Sangregorio, and M.G. Roncarolo Human CD4+CD25+ T regulatory cells suppress naïve and memory T cell proliferation and can be expanded in vitro without loss of function J Exp Med 193 2001 1295 1301
13. W.F. Ng, P.J. Duggan, F. Ponchel, G. Matarese, G. Lombardi, A.D. Edwards, J.D. Isaacs, and R.I. Lechler Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells Blood 98 2001 2736 2744
14. C. Baecher-Allan, J.A. Brown, G.J. Freeman, and D.A. Hafler CD4+CD25 high regulatory cells in human peripheral blood J Immunol 167 2001 1245 1253
15. H. Jonuleit, and E. Schmitt The regulatory T cell family: distinct subsets and their interrelations J Immunol 171 2003 6323 6327
16. A.M. Silverstein, and N.R. Rose There is only one immune system! The view from immunopathology Semin Immunol 12 2000 173 178
17. T. Mosmann Complexity or coherence? Cytokine secretion by B cells Nat Immunol 6 2000 465 466
18. L.J. Taylor, J. Bagg, and D.M. Walker Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration J Oral Pathol Med 21 1992 21 25
19. A. Sun, J.S. Chia, Y.F. Chang, and C.P. Chiang Levamisole and Chinese medicinal herbs can modulate the serum interleukin-6 level in patients with recurrent aphthous ulcerations J Oral Pathol Med 32 2003 206 214
20. A. Sun, Y.F. Chang, J.S. Chia, and C.P. Chiang Serum Interleukin-8 level is a more sensitive marker than serum interleukin-6 level in monitoring the disease activity of recurrent aphthous ulcerations J Oral Pathol Med 33 2004 133 139
21. J. Freysdottir, H. Lau, and F. Fortune Gammadelta T cells in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS) Clin Exp Immunol 118 1999 451 457
22. I.J. Buno, J.C. Huff, W.L. Weston, D.T. Cook, and S.L. Brice Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis Arch Dermatol 134 1998 827
23. S. Natah, R. Hayrinen-Immonen, J. Heitanen, M. Malstrom, and Y. Konttinen Immunolocalization of tumor necrosis factor-alpha expressing cells in recurrent aphthous ulcers lesions (RAU) J Oral Pathol Med 29 2000 19 25
24. R.C. Borra, P.M. Andrade, I.D.C.G. Silva, A. Morgun, L.L.M. Weckx, A.S. Smirnova, and M. Franco The Th1/Th2 immune-type response of the recurrent aphthous ulceration analyzed by cDNA microarray J Oral Pathol Med 33 2004 140 146
25. N. Lewkowicz, P. Lewkowicz, A. Kurnatowska, M. Banasik, E. Glowacka, M. Cedzynski, A. Swierzko, B. Lauk-Puchala, and H. Tchorzewski Innate immune system is implicated in recurrent aphthous ulcer pathogenesis J Oral Pathol Med 32 2003 475 481
26. M.R. Bazrafshanu, A.H. Hajeer, W.E. Ollier, and M.H. Thornhill IL-1β and IL-6 polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS) Genes Immun 3 2002 302 305
27. M.R. Bazrafshanu, A.H. Hajeer, W.E. Ollier, and M.H. Thornhill Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF-α, TNF-β and the vitamin D receptor: no association detected Oral Dis 8 2002 303 307