Innate immune system is implicated in recurrent aphthous ulcer pathogenesis

Journal of Oral Pathology and Medicine

Volumn 32, Issue 8, 2003, Pages 475-481

  Lewkowicz, Natalia ^a   Lewkowicz, Przemyslaw ^b   Kurnatowska, Anna ^a   Banasik, Malgorzata ^b   Glowacka, Ewa ^b   Cedzyński, Maciej ^c   Świerzko, Anna ^c   Lauk Puchala, Bozena ^b   Tchórzewski, Henryk ^b,c  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

^c POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Innate immunity; Recurrent aphthous ulcers

Indexed keywords

CD11B ANTIGEN; COMPLEMENT COMPONENT C3C; COMPLEMENT COMPONENT C4; MANNOSE BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RECEPTOR 1;

APHTHOUS ULCER; ARTICLE; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LEUKOCYTE ACTIVATION; MALE; NEUTROPHIL; OXIDATIVE STRESS;

ADOLESCENT; ADULT; ANTIGENS, CD; ANTIGENS, CD11B; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL RESPONSE MODIFIERS; COMPLEMENT C3C; COMPLEMENT C4; FEMALE; HEMOLYSIS; HUMANS; IMMUNOGLOBULIN G; MALE; MANNOSE-BINDING LECTIN; MIDDLE AGED; NEUTROPHIL ACTIVATION; NEUTROPHILS; REACTIVE OXYGEN SPECIES; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; RECURRENCE; STOMATITIS, APHTHOUS;

EID: 0041926739     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0714.2003.00181.x     Document Type: Article

References (31)

1. Ship JA, Arbor A. Recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1996; 81: 141-7.
2. Porter SR, Scully C, Pedersen A. Recurrent aphthous stomatitis. Crit Rev Oral Biol Medical 1998; 9: 306-31.
3. Savage NW, Seymour GJ, Kruger BJ. Expression of class I and II major histocompatibility complex antigens on epithelial cells in recurrent aphthous stomatitis. J Oral Pathol 1986; 15: 191-5.
4. Taylor LJ, Bagg J, Walker DM, Peters TJ. Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration. J Oral Pathol Med 1992; 21: 21-5.
5. Pedersen A, Ryder LP. γδ T-cell fraction of peripheral blood is increased in recurrent aphthous ulceration. Clin Immunol Immunopathol 1994; 72: 98-104.
6. Healy CM, Carvalho D, Pearson JD, Thornhill MH. Raised levels of circulating VCAM-1 and circulating E-selectin in patients with recurrent oral ulceration. J Oral Pathol Med, 1997; 26: 23.
7. Natah SS, Hayrinen-Immonen R, Heitanen J, Malastrom M, Konttinen YT. Factor XIIIa-positive dendrocytes are increased in number and size in recurrent aphthous ulcers (RAU). J Oral Pathol Med 1997; 26: 408-13.
8. Buno IJ, Huff JC, Weston WL, Cook DT, Brice SL. Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis. Arch Dermatol 1998 134: 827-31.
9. Natah SS, Hayrinen-Immonen R, Heitanen J, Malstrom M, Konttinen YT. Quantitative assessment of mast cells in recurrent aphthous ulcers (RAU). J Oral Pathol Med 1998; 27: 124-9.
10. Healy CM, Thornhill MH. Induction of adhesion molecule expression on blood vessels and keratinocytes in recurrent oral ulceration. J Oral Pathol Med 1999; 28: 5-11.
11. Natah SS, Hayrinen-Immonen R, Hietanen J, Malstrom M, Kontinnen YT. Immunolocalization of tumor necrosis factor-alpha expressing cells in recurrent aphthous ulcers lesions (RAU). J Oral Pathol Med 2000; 29: 19-25.
12. Natah S, Hayrinen-Immonen R, Heitanen J, et al. Increased density of lymphocytes bearing gamma-delta T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg 2000; 29: 375-80.
13. Sun A, Chu CT, Liu BY, Wang JT, Leu JS, Chiang CP. Expression of interleukin-2 receptor by activated peripheral blood lymphocytes up-regulated by the plasma level of interleukin-2 on patients with recurrent aphthous ulcers. Proc Natl Sci Counc Repub China 2000; 24: 116-22.
14. Hasan A. Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers. Clin Exp Immunol 1995; 99: 392-7.
15. Healy CM, Carvalho D, Pearson JD, Thornhill MH. Raised antiendothelial cell autoantibodies (AECA), but not anti-neutrophil cytoplasmic autoantibodies (ANCA), in recurrent oral ulceration: modulation of AECA binding by tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Clin Exp Immunol 1996; 106: 523.
16. Sun A, Hsieh RP, Liu BY. Strong association of antiepithelial cell antibodies with HLA-DR3 or DR7 phenotype in patients recurrent oral ulcers. J Formos Med Assoc 2000; 99: 290-4.
17. Sun A, Wu YC, Wang JT, Liu BY, Chiang CP. Association of HLA-te22 antigen with anti-nuclear antibodies in Chinese patients with erosive oral lichen planus. Proc Natl Sci Counc Repub China 2000; 24: 63-9.
18. Dagalis P, Bagg J, Walker D. Spontaneous migration and chemotactic activity of neutrophil polymorphonuclear leukocytes in recurrent aphthous ulceration. Oral Surg Oral Med Oral Pathol 1987; 64: 298-301.
19. Wray D, Charon J. Polymorphonuclear neutrophil function in recurrent aphthous stomatitis. J Oral Pathol Med 1991; 20: 392-4.
20. Ueta E, Osaki T, Yoneda K. A clinical trial of Azelastine recurrent aphthous ulceration, With an analysis of its actions on leukocytes. J Oral Pathol Med 1994; 23: 123-9.
21. Sistig S, Cekic-Arambasin A, Rabatic S, Vucicevic-Boras V, Kleinheinz J, Piffko J. Natural immunity in recurrent aphthous ulceration. J Oral Pathol Med 2001; 30: 275-80.
22. Lloyd AR, Oppenheim JJ. Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol Today 1992; 13: 169-72.
23. Condliffe AM, Kitchen E, Chilvers ER. Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci 1998; 94: 461-7.
24. Mayer MM. Studies on the mechanism of hemolysis by antibody and complement. Prog Allergy 1958; 5: 215-20.
25. Dahlgren C, Karlsson A. Respiratory burst in human neutrophils. J Immunol Meth 1999; 232: 3-14.
26. Bemelmans M, Gouma D, Burman W. LPS-induced sTNF-receptor release in vivo murine model. J Immunol 1993; 151: 5554.
27. Ward P, McLeich K. Polymorphonuclear leukocyte oxidative burst is enhanced in patients with chronic renal insufficiency. J Am Soc Nephrol 1995; 9: 1697-702.
28. Ward P. Neutrophils and adjuvant arthritis. Clin Exp Immunol 1997; 107: 225-6.
29. Balazovich K, Suchard S, Remick D, Boxer L. Tumor necrosis factor-α and fMLP receptors are functionally linked during fMLP-stimulated activation of adherent human neutrophils. Blood 1996; 2: 690-6.
30. Cedzyński M, Swierzko A. Mannose-binding lectin - a molecule important in innate immunity. Centr Eur J Immunol 2000; 25: 1-5.
31. Kawasaki T, Ma Y, Uemura K, Kawasaki N. Mannan-binding protein (MBP)-dependent cell-mediated cytotoxicity (MDCC). Immunopharm 2000; 49: 85-91.