Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction

Steroids

Volumn 70, Issue 8, 2005, Pages 515-524

  Hill, Martin ^a   Popov, Petr ^b   Havlíková, Helena ^a   Kancheva, Lyudmila ^a   Vrbíková, Jana ^a   Kancheva, Radmila ^a   Pouzar, Vladimír ^c   Černý, Ivan ^c   Stárka, Luboslav ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Alcohol detoxification; GC MS; Neuroactive steroids; Pregnanolone isomers; Pregnenolone sulfate; Premenopausal women

Indexed keywords

17 HYDROXYPREGNENOLONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA HYDROXY 5BETA PREGNAN 20 ONE; ALCOHOL; ELTANOLONE; ESTRADIOL; GESTAGEN; HYDROCORTISONE; HYDROXYPROGESTERONE; ISOPREGNANOLONE; PRASTERONE; PRASTERONE SULFATE; PREGNENOLONE; PROGESTERONE; STEROID; UNCLASSIFIED DRUG;

ADULT; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; FEMALE; GAS CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; MASS SPECTROMETRY; MENSTRUAL CYCLE; PREMENOPAUSE; PROGESTERONE BLOOD LEVEL; PROGESTERONE SYNTHESIS; PSYCHOSOMATICS; RADIOIMMUNOASSAY; STEROIDOGENESIS;

ALCOHOLISM; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROCORTISONE; PREGNANOLONE; PREGNENOLONE; PREMENOPAUSE; PROGESTERONE; RADIOIMMUNOASSAY; STEREOISOMERISM; STEROIDS; TIME FACTORS;

EID: 19344365160     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2005.02.013     Document Type: Article

References (54)

1. J.N. Hugues, T. Coste, G. Perret, M.F. Jayle, J. Sebaoun, and E. Modigliani Hypothalamo-pituitary ovarian function in thirty-one women with chronic alcoholism Clin Endocrinol (Oxf) 12 1980 543 551
2. B. McNamee, J. Grant, J. Ratcliffe, W. Ratcliffe, and J. Oliver Lack of effect of alcohol on pituitary-gonadal hormones in women Br J Addict Alcohol Other Drugs 74 1979 316 317
3. M. Valimaki, M. Harkonen, and R. Ylikahri Acute effects of alcohol on female sex hormones Alcohol Clin Exp Res 7 1983 289 293
4. J.H. Mendelson, N.K. Mello, P. Cristofaro, J. Ellingboe, A. Skupny, and S.L. Palmieri Alcohol effects on naloxone-stimulated luteinizing hormone, prolactin and estradiol in women J Stud Alcohol 48 1987 287 294
5. S.K. Teoh, J.H. Mendelson, N.K. Mello, and A. Skupny Alcohol effects on naltrexone-induced stimulation of pituitary, adrenal, and gonadal hormones during the early follicular phase of the menstrual cycle J Clin Endocrinol Metab 66 1988 1181 1186
6. J.H. Mendelson, N.K. Mello, S.K. Teoh, and J. Ellingboe Alcohol effects on luteinizing hormone releasing hormone-stimulated anterior pituitary and gonadal hormones in women J Pharmacol Exp Ther 250 1989 902 909
7. T. Sarkola, H. Makisalo, T. Fukunaga, and C.J. Eriksson Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women Alcohol Clin Exp Res 23 1999 976 982
8. S. Andersson, and N. Moghrabi Physiology and molecular genetics of 17 beta-hydroxysteroid dehydrogenases Steroids 62 1997 143 147
9. S.K. Teoh, J.H. Mendelson, N.K. Mello, A. Skupny, and J. Ellingboe Alcohol effects on hCG-stimulated gonadal hormones in women J Pharmacol Exp Ther 254 1990 407 411
10. S. Saxena, D. Meehan, P. Coney, and J. Wimalasena Ethanol has direct inhibitory effects on steroidogenesis in human granulosa cells: specific inhibition of LH action Alcohol Clin Exp Res 14 1990 522 527
11. J.M. Torres, and E. Ortega Alcohol intoxication increases allopregnanolone levels in female adolescent humans Neuropsychopharmacology 28 2003 1207 1209
12. C.A. Martin, A.G. Mainous III, T. Curry, and D. Martin Alcohol use in adolescent females: correlates with estradiol and testosterone Am J Addict 8 1999 9 14
13. M. Garcia-Closas, J. Herbstman, M. Schiffman, A. Glass, and J.F. Dorgan Relationship between serum hormone concentrations, reproductive history, alcohol consumption and genetic polymorphisms in pre-menopausal women Int J Cancer 102 2002 172 178
14. P. Pettersson, B.M. Ellsinger, C. Sjoberg, and P. Bjorntorp Fat distribution and steroid hormones in women with alcohol abuse J Intern Med 228 1990 311 316
15. J. Wimalasena, D. Meehan, R. Dostal, and M. de Silva Selective inhibition of luteinizing hormone action by ethanol in cultured human granulosa cells Alcohol Clin Exp Res 17 1993 340 344
16. M.D. Majewska Steroid regulation of the GABAA receptor: ligand binding, chloride transport and behaviour Ciba Found Symp 153 1990 83 97
17. M.D. Majewska, S. Demirgoren, and E.D. London Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor Eur J Pharmacol 189 1990 307 315
18. F.S. Wu, T.T. Gibbs, and D.H. Farb Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-d-aspartate receptor Mol Pharmacol 40 1991 333 336
19. 3H]SR 95531 binding to the GABAA recognition site Eur J Pharmacol 304 1996 141 146
20. P. Poisbeau, P. Feltz, and R. Schlichter Modulation of GABAA receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model J Physiol (Lond) 500 1997 475 485
21. 2+ in cultured rat hippocampal neurons Neurosci Lett 141 1992 30 34
22. M. Park-Chung, F.S. Wu, R.H. Purdy, A.A. Malayev, T.T. Gibbs, and D.H. Farb Distinct sites for inverse modulation of N-methyl-d-aspartate receptors by sulfated steroids Mol Pharmacol 52 1997 1113 1123
23. C.D. Putnam, D.W. Brann, R.C. Kolbeck, and V.B. Mahesh Inhibition of uterine contractility by progesterone and progesterone metabolites: mediation by progesterone and gamma amino butyric acid A receptor systems Biol Reprod 45 1991 266 272
24. R. Rupprecht, B. Berning, C.A. Hauser, F. Holsboer, and J.M. Reul Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship Eur J Pharmacol 303 1996 227 234
25. L.R. Gerak, M.W. Stevenson, P.J. Winsauer, and J.M. Moerschbaecher Effects of pregnanolone alone and in combination with other positive GABAA modulators on complex behavior in rats Psychopharmacology (Berl) 173 2004 195 202
26. P. Lundgren, J. Stromberg, T. Backstrom, and M. Wang Allopregnanolone- stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha- pregnan-20-one (isoallopregnanolone) Brain Res 982 2003 45 53
27. R.J. Prince, and M.A. Simmonds 5Beta-pregnan-3 beta-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex Neurosci Lett 135 1992 273 275
28. A.D. Barbosa, and G.S. Morato Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol Brain Res Bull 58 2002 99 105
29. A.D. Barbosa, and G.S. Morato Influence of neurosteroids on the development of rapid tolerance to ethanol in mice Eur J Pharmacol 431 2001 179 188
30. A.D. Barbosa, and G.S. Morato Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance to ethanol Pharmacol Biochem Behav 67 2000 459 464
31. I. Cerny, V. Pouzar, M. Budesinsky, M. Bicikova, M. Hill, and R. Hampl Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates Steroids 69 2004 161 171
32. M. Hill, A. Parizek, M. Bicikova, H. Havlikova, J. Klak, and T. Fait Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood: 1. Identification and simultaneous determination of pregnanolone isomers J Steroid Biochem Mol Biol 75 2000 237 244
33. M. Hill, R. Hampl, D. Lukac, O. Lapcik, V. Pouzar, and J. Sulcova Elimination of cross-reactivity by addition of an excess of cross-reactant for radioimmunoassay of 17alpha-hydroxypregnenolone Steroids 64 1999 341 355
34. M. Hill, H. Havlikova, J. Klak, M. Bicikova, V. Pouzar, and R. Hampl Rapid immunoassay for pregnenolone sulfate and its applications in endocrinology Collect Czech Chem Commun 67 2002 140 162
35. L. Langer, J. Veleminsky, R. Hampl, L. Starka, and J. Holan Radioimmunoassay of plasma progesterone Radiochem Radioanal Lett 34 1978 267 272
36. K. Parivar, A. Wessen, M. Widman, and A. Nilsson Pharmacokinetics of eltanolone following bolus injection and constant rate infusion J Pharmacokinet Biopharm 24 1996 535 549
37. W.J. Hering, H. Ihmsen, H. Langer, C. Uhrlau, M. Dinkel, and G. Geisslinger Pharmacokinetic-pharmacodynamic modeling of the new steroid hypnotic eltanolone in healthy volunteers Anesthesiology 85 1996 1290 1299
38. P. Carl, S. Hogskilde, T. Lang-Jensen, V. Bach, J. Jacobsen, and M.B. Sorensen Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans Acta Anaesthesiol Scand 38 1994 734 741
39. M. Bixo, A. Andersson, B. Winblad, R.H. Purdy, and T. Backstrom Progesterone, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-5alpha-pregnane-20- one in specific regions of the human female brain in different endocrine states Brain Res 764 1997 173 178
40. M. Bixo, T. Backstrom, B. Winblad, and A. Andersson Estradiol and testosterone in specific regions of the human female brain in different endocrine states J Steroid Biochem Mol Biol 55 1995 297 303
41. D. Zhu, M.D. Wang, T. Backstrom, and G. Wahlstrom Evaluation and comparison of the pharmacokinetic and pharmacodynamic properties of allopregnanolone and pregnanolone at induction of anaesthesia in the male rat Br J Anaesth 86 2001 403 412
42. M.D. Wang, G. Wahlstrom, and T. Backstrom The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion J Steroid Biochem Mol Biol 62 1997 299 306
43. M.A. Sortino, M. Chisari, S. Merlo, C. Vancheri, M. Caruso, and F. Nicoletti Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death Endocrinology 145 2004 5080 5086
44. C.P. Spencer, I.F. Godsland, and J.C. Stevenson Is there a menopausal metabolic syndrome? Gynecol Endocrinol 11 1997 341 355
45. C. Gianoulakis, X. Dai, and T. Brown Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender Alcohol Clin Exp Res 27 2003 410 423
46. H. Hasselbalch, J. Selmer, L. Sestoft, and H. Kehlet Hypothalamic- pituitary-adrenocortical function in chronic alcoholism Clin Endocrinol (Oxf) 16 1982 73 76
47. E. Vallina Alvarez, P. Villaverde Amieva, J. Rodriguez Sanchez, M. Gallego Villalobos, E. Gonzalez Fernandez, and J.M. Arribas Castrillo Hypophysio-adrenal axis in patients with chronic alcoholism Ann Med Interna 19 2002 626 628
48. L. Dazzi, A. Sanna, E. Cagetti, A. Concas, and G. Biggio Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats Brain Res 710 1996 275 280
49. M. Kajta, B. Budziszewska, and W. Lason Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells Pol J Pharmacol 51 1999 531 534
50. E.M. Lockhart, D.S. Warner, R.D. Pearlstein, D.H. Penning, S. Mehrabani, and R.M. Boustany Allopregnanolone attenuates N-methyl-d-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture Neurosci Lett 328 2002 33 36
51. M. Matsunaga, K. Okuhara, K. Ukena, and K. Tsutsui Identification of 3beta,5beta-tetrahydroprogesterone, a progesterone metabolite, and its stimulatory action on preoptic neurons in the avian brain Brain Res 1007 2004 160 166
52. M.C. Gravielle, A.M. de Novara, and S. Fiszer de Plazas GABA-stimulated chloride uptake during avian CNS development: modulation by neurosteroids Int J Dev Neurosci 16 1998 469 475
53. M.S. Viapiano, and S. Fiszer de Plazas Comparative modulation by 3 alpha,5 alpha and 3 beta,5 beta neurosteroids of GABA binding sites during avian central nervous system development Neurochem Res 23 1998 155 161
54. L. Pignataro, and S. Fiszer de Plazas Epipregnanolone acts as a partial agonist on a common neurosteroid modulatory site of the GABA(A) receptor complex in avian CNS Neurochem Res 22 1997 221 225