Steroid receptor-mediated effects of neuroactive steroids: Characterization of structure-activity relationship

European Journal of Pharmacology

Volumn 303, Issue 3, 1996, Pages 227-234

  Rupprecht, Rainer ^a   Berning, Barbara ^a   Hauser, Charlotte A E ^a   Holsboer, Florian ^a   Reul, Johannes M H M ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

gene expression; neuroactive steroid; neurosteroid; progesterone receptor

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA DIHYDRODEOXYCORTICOSTERONE; 5ALPHA PREGNANE 3,20 DIONE; 5BETA DIHYDROPROGESTERONE; ALFAXALONE; ALLOTETRAHYDRODEOXYCORTICOSTERONE; ANDROGEN RECEPTOR; DEXAMETHASONE; ELTANOLONE; GLUCOCORTICOID RECEPTOR; METRIBOLONE; NEUROACTIVE STEROID; PRASTERONE; PREGNANOLONE SULFATE; PREGNENOLONE; PROGESTERONE; PROGESTERONE RECEPTOR; PROMEGESTONE; RADIOLIGAND; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL METABOLISM; CHICKEN; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENOME; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0029937131     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00036-2     Document Type: Article

References (41)

1. Akwa, Y., J. Young, K. Kabbadj, M.J. Sancho, D. Zucman, C. Vourc'h, I. Jung-Testas, Z.Y. Hu, C. Le Goascogne, D.H. Jo, C. Corpéchot, P. Simon, E.E. Baulieu and P. Robel, 1991, Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain, J. Steroid. Biochem. 40, 71.
2. Araneo, B. and R. Daynes, 1995, Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury, Endocrinology 136, 393.
3. Arriza, J.L., C. Weinberger, G. Cerelli, T.M. Glaser, B.L. Handelin, D.E. Housman and R.M. Evans, 1987, Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor, Science 237, 268.
4. Browne, E.S., J.R. Porter, G. Correa, J. Abadie and F. Svec, 1993, Dehydroepiandrosterone regulation of the hepatic glucocorticoid receptor in the zucker rat. The obesity research program, J. Steroid Biochem. Mol. Biol. 45, 517.
5. 50) of an enzymatic reaction, Biochem. Pharmacol. 22, 3099.
6. Chu, G., H. Hayaka and P. Berg, 1987, Electroporation for the efficient transfection of mammalian cells with DNA, Nucleic Acids Res. 15, 1311.
7. Conneely, O.M., D.M. Kettelberger, M.J. Tsai, W.T. Schrader and B.W. O'Malley, 1989, The chicken progesterone receptor A and B isoforms are products of an alternate translation event, J. Biol. Chem. 264, 14062.
8. Crawley, J.N., J.R. Glowa, M.D. Majewska and S.M. Paul, 1986, Anxiolytic activity of an endogenous adrenal steroid, Brain Res. 398, 382.
9. DeWet, J.R., K.V. Wood, M. DeLuca, D.R. Helsinki and S. Subramani, 1987, Firefly luciferase gene: structure and expression in mammlian cells, Mol. Cell. Biol. 7, 725.
10. Evans, R.M. 1988, The steroid and thyroid hormone receptor superfamily, Science 240, 889.
11. Flood, J.F., G.E. Smith and E. Roberts, 1988, Dehydroepiandrosterone and its sulfate enhance memory retention in mice, Brain Res. 447, 269.
12. Friess, E., L. Trachsel, J. Guldner, T. Schier, A. Steiger and F. Holsboer, 1995, DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range, Am. J. Physiol. 268, E107.
13. Gee, K.W., M.B. Bolger, R.E. Brinton, H. Coirini and B.S. McEwen, 1988, Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependance and mechanism of action, J. Pharmacol. Exp. Ther. 246, 803.
14. A receptors by neuroactive steroids, Eur. J. Pharmacol. Mol. Pharmacol. Section 289, 249.
15. Herbomel, P., B. Bourachot and M. Yanif, 1984, Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma, Cell 39, 653.
16. Hollenberg, S.M. and R.M. Evans, 1988, Multiple and cooperative trans-activation domains of the human glucocorticoid receptor, Cell 55, 899.
17. Hollenberg, S.M., C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, R. Lebo, E.B. Thompson, M.G. Rosenfeld and R.M. Evans, 1985, Primary structure and expression of a functional glucocorticoid receptor cDNA, Nature 318, 635.
18. Kastner, P., M. Bocquel, B.P. Turcotte, J.M. Garnier, K.B. Horwitz, B. Chambon and H. Gronemeyer, 1990, Transient expression of human and chicken progesterone receptors does not support alternative translation initiation from a single mRNA as the mechanism generating two receptor isoforms, J. Biol. Chem. 265, 12163.
19. Krause, J.E. and H.J. Karavolas, 1980, Pituitary 5α-dihydroprogesterone 3α-hydroxysteroid oxidoreductases, J. Biol. Chem. 255, 11807.
20. Kubli-Garfias, C. 1984, Physiological role of 5α- and 5β-progesterone metabolites on the CNS, Trends Pharmacol. Sci. 5, 439.
21. Lan, N.C., K.W. Gee, M.B. Bolger and J.S. Chen, 1991, Differential responses of expressed recombinant human gamma-aminobutyric acid A receptors to neurosteroids, J. Neurochem. 57, 1818.
22. Lancel, M., T.A.M. Crönlein, P. Müller-Preuß and F. Holsboer, 1994, Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat in contrast to midazolam, Brain Res. 646, 85.
23. Majewska, M.D., N.L. Harrison, R.D. Schwartz, J.L. Barker and S.M. Paul, 1986, Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor, Science 232, 1004.
24. Majewska, M.D., J.-M. Mienville and S. Vicini, 1988, Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons, Neurosci. Lett. 90, 279.
25. A receptor, Brain Res. 526, 143.
26. McEwen, B.S. 1991, Non-genomic and genomic effects of steroids on neural activity, Trends Pharmacol. Sci. 12, 141.
27. Morrow, A.L., J.R. Pace, R.H. Purdy and S.M. Paul, 1990, Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites, Mol. Pharmacol. 37, 263.
28. Paul, S.M. and R.H. Purdy, 1992, Neuroactive steroids, FASEB J. 6, 2311.
29. Perrot-Applanat, M., M. Groyer-Picard, F. Lorenzo, A. Jolivet, M.T.V. Hai, C. Pallud, F. Spyratos and E. Milgrom, 1987, Immunocytochemical study with monoclonal antibodies to progesterone receptor in human breast tumors, Cancer Res. 47, 2652.
30. A receptors, Neuron 4, 759.
31. Purdy, R.H., A.L. Morrow, J.R. Blinn and S.M. Paul, 1990, Synthesis, metabolism, and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptosomes, J. Med. Chem. 33, 1572.
32. Rupprecht, R., J.L. Arriza, D. Spengler, J.M.H.M. Reul, R.M. Evans, F. Holsboer and K. Damm, 1993a, Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor, Mol. Endocrinol. 7, 597.
33. Rupprecht, R., J.M.H.M. Reul, T. Trapp, B. van Steensel, C. Wetzel, K. Damm, W. Zieglgänsberger and F. Holsboer, 1993b, Progesterone receptor-mediated effects of neuroactive steroids, Neuron 11, 523.
34. Rupprecht, R., J.M.H.M. Reul, B. van Steensel, D. Spengler, M. Söder, B. Berning, F. Holsboer and K. Damm, 1993c, Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands, Eur. J. Pharmacol. Mol. Pharmacol. Section 247, 145.
35. A-receptor modulation. Brain Res. 615, 267.
36. Tan, J., D.R. Joseph, V.E. Quarmby, D.B. Lubahn, M. Sar, F.S. French and E.M. Wilson, 1988, The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein, Mol. Endocrinol. 12, 1276.
37. Trapp, T., R. Rupprecht, M. Castrén, J.M.H.M. Reul and F. Holsboer, 1994, Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS, Neuron 13, 1457.
38. Vedder, H., F. Parlow, W. Zieglgänsberger and F. Holsboer, 1993, Neurosteroids do not regulate proopiomelanocortin-gene expression in pituitary cells, Exp. Clin. Endocrinol. 101, 161.
39. Wieland, S., J.D. Belluzi, L. Stein and N.C. Lan, 1995, Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents, Psychopharmacology 118, 65.
40. Wu, F.-S., T.T. Gibbs and D.H. Farb, 1990, Inverse modulation of γ-aminobutyric acid- and glycine-induced currents by progesterone, Mol. Pharmacol. 37, 597.
41. Wu, F.-S., T.T. Gibbs and D.H. Farb, 1991, Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor, Mol. Pharmacol. 40, 333.