Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids

Molecular Pharmacology

Volumn 52, Issue 6, 1997, Pages 1113-1123

  Park Chung, Mijeong ^a,c   Wu, Fong Sen ^a,d   Purdy, Robert H ^b   Malayev, Andrew A ^a   Gibbs, Terrell T ^a   Farb, David H ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Institute of Bioscience and Biotechnology   (South Korea)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; DIZOCILPINE; GLYCINE; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROSTEROID; PREGNENOLONE SULFATE; SPERMINE; STEROID;

ANIMAL CELL; ARTICLE; CHICKEN; CONTROLLED STUDY; DRUG SULFATION; GENE EXPRESSION; HIPPOCAMPUS; NERVE CELL CULTURE; NEUROMODULATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SPINAL CORD; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION; XENOPUS LAEVIS;

EID: 0031467726     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.6.1113     Document Type: Article

References (40)

1. Paul, S. M., and R. H. Purdy. Neuroactive steroids. FASEB J. 6:2311-2322 (1992).
2. Farb, D. H., T. T. Gibbs, F.-S. Wu, M. Gyenes, L. Friedman, and S. J. Russek. Steroid modulation of amino acid neurotransmitter receptors, in GABAergic Synaptic Transmission: Molecular, Pharmacological, and Clinical Aspects (G. Biggio, A. Concas, and E. Costa, eds.). Raven Press, New York, 119-131 (1992).
3. Flood, J. F., J. E. Morley, and E. Roberts. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc. Natl. Acad. Sci. USA 92:10806-10810 (1995).
4. Vermeulen, A. Dehydroepiandrosterone sulfate and aging. Ann. N. Y. Acad. Sci. 774:121-7 (1995).
5. Bélanger, A., B. Candas, A. Dupont, L. Cusan, P. Diamond, J. L. Gomez, and F. Labrie. Changes in serum concentrations of conjugated and unconjugated steroids in 40-to 80-year-old men. J. Clin. Endocrinol. Metab. 79:1086-90 (1994).
6. Flood, J. F., and E. Roberts. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res. 448:178-181 (1988).
7. Paganini-Hill, A., and V. Henderson. Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 140:2560-261 (1994).
8. Majewska, M. D., and R. D. Schwartz. Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain? Brain Res. 404:355-360 (1987).
9. A receptor research. Synapse 21:189-274 (1995).
10. Wu, F.-S., T. T. Gibbs, and D. H. Farb. Inverse modulation of γ-aminobutyric acid- and glycine-induced currents by progesterone. Mol. Pharmacol. 37:597-602 (1990).
11. Wu, F.-S., T. T. Gibbs, and D. H. Farb. Pregnenolone sulfate: a positive allosteric modulator at the NMDA receptor. Mol. Pharmacol. 40:333-336 (1991).
12. 2+ in cultured rat hippocampal neurons. Neurosci. Lett. 141:30-34 (1992).
13. ++ responses: structure activity studies. J. Pharmacol. Exp. Ther. 271:677-682 (1994).
14. Maione, S., L. Berrino, S. Vitagliano, J. Leyva, and F. Rossi. Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice. Eur. J. Pharmacol. 219:477-479 (1992).
15. Flood, J. F., J. E. Morley, and E. Roberts. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc. Natl Acad. Sci. USA 89:1567-1571 (1992).
16. Mayo, W., F. Dellu, P. Robel, J. Cherkaoui, M. Le Moal, E. E. Baulieu, and H. Simon. Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat. Brain Res. 607:324-328 (1993).
17. Mathis, C., M. S. Paul, and N. J. Crawley. The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. Psychopharmacology 116:201-206 (1994).
18. Cheney, D. L., D. Uzunov, and A. Guidotti. Pregnenolone sulfate antagonizes dizocilpine amnesia: role for allopregnenolone. Neuroreport 6:1697-1700 (1995).
19. Li, P. K., M. E. Rhodes, S. Jagannathan, and D. A. Johnson. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate. Brain Res. Cogn. Brain Res. 2:251-254 (1995).
20. Park-Chung, M., F.-S. Wu, and D. H. Farb. 3α-Hydroxy-5β-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons. Mol. Pharmacol. 46:146-150 (1994).
21. Sprosen, T. S., and G. N. Woodruff. Polyamines potentiate NMDA induced whole-cell currents in cultured striatal neurons. Eur. J. Pharmacol. 179: 477-478 (1990).
22. Aizenman, E., S. A. Lipton, and R. H. Loring. Selective modulation of NMDA responses by reduction and oxidation. Neuron 2:1257-1263 (1989).
23. Miller, B., M. Sarantis, S. F. Traynelis, and D. Attwell. Potentiation of NMDA receptor currents by arachidonic acid. Nature (Lond.) 355:722-725 (1992).
24. Huettner, J. E., and B. P. Bean. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc. Natl. Acad. Sci. USA 85:1307-1311 (1988).
25. Brewer, G. J., and C. W. Cotman. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res. 494:65-74 (1989).
26. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflueg. Arch. Eur. J. Physiol. 391:85-100 (1981).
27. Dusza, J. P., and J. P. Joseph. Steroids conjugate. IV. The preparation of steroids sulfates with triethylamine-sulfur trioxide. Steroids 12:49-61 (1968).
28. Choi, D. W., and G. D. Fischbach. GABA conductance of chick spinal cord and dorsal root ganglion neurons in cell culture. J. Neurophysiol. 45:605-620 (1981).
29. Chan, C. Y., and D. H. Farb. Modulation of neurotransmitter action: control of the γ-aminobutyric acid response through the benzodiazepine receptor. J. Neurosci. 5:2365-2373 (1985).
30. Yaghoubi, N., A. A. Malayev, T. T. Gibbs, and D. H. Farb. The effects of neuroactive steroids on recombinant NMDA receptors. Soc. Neurosci. Abstr. 22:1280 (1996).
31. Williams, K., A. M. Zappia, D. B. Pritchett, Y. M. Shen, and P. B. Molinoff. Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. Mol. Pharmacol. 45:803-9 (1994).
32. Durand, G. M., M. V. Bennett, and R. S. Zukin. Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc. Natl. Acad. Sci. USA 90:6731-6735 (1993).
33. Bowlby, M. Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. Mol. Pharmacol. 43:813-819 (1993).
34. Wong, M., and R. L. Moss. Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels. J. Neuroendocrinol. 6:347-355 (1994).
35. Petrou, S., W. O. Richard, J. J. Singer, and V. J. Walsh, Jr. A putative fatty acid binding domain of the NMDA receptor. Trends Biochem. Sci. 18:12-13 (1993).
36. Lovinger, D. M., G. White, and F. F. Weight. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science (Washington D. C.) 243:1721-1724 (1989).
37. Corpéchot, C., M. Synguelakis, S. Talha, M. Axelson, J. Sjöval, R. Vihko, E.-E. Baulieu, and P. Robel. Pregnenolone and its sulfate ester in the rat brain. Brain Res. 270:119-125 (1983).
38. Sjövall, K. Gas chromatographic determination of steroid sulfates in plasma during pregnancy. Ann. Clin. Res. 2:393-408 (1970).
39. Globus, M., M. D. Ginsberg, and R. Busto. Excitotoxic index: a biochemical marker of selective vulnerability. Neurosci. Lett. 127:39-42 (1991).
40. Rehncrona, S., E. Westerberg, B. Akesson, and B. K. Siesjo. Brain cortical fatty acids and phospholipids during and following complete and severe incomplete ischemia, J. Neurochem. 38:84-93 (1982).