Steroid inhibition of [3H]SR 95531 binding to the GABA(A) recognition site

European Journal of Pharmacology

Volumn 304, Issue 1-3, 1996, Pages 141-146

  Hawkinson, Jon E ^a   Acosta Burruel, Manuel ^a   Kimbrough, Catherine L ^a   Goodnough, Dayan B ^a,b   Wood, Paul L ^a  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b Enviro Test Laboratories   (Canada)

Author keywords

3 hydroxy 5 pregnan 20 one; GABA(A) receptor; neuroactive steroid; neurosteroid; pregnenolone sulfate; RU 5135; SR 95531

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 3ALPHA HYDROXY 16 IMINO 5BETA 17 AZAANDROSTAN 11 ONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; DIAZEPAM; ELTANOLONE; GABAERGIC RECEPTOR AFFECTING AGENT; NEUROSTEROID; PENTOBARBITAL; PHENOBARBITAL; PRASTERONE SULFATE; PREGNENOLONE SULFATE; RADIOLIGAND; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANDROSTANE DERIVATIVE; AZASTEROID; DEOXYCORTICOSTERONE; DRUG DERIVATIVE; PREGNENOLONE; PYRIDAZINE DERIVATIVE; STEROID; TETRAHYDRODEOXYCORTICOSTERONE;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING SITE; BRAIN CORTEX; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; ANIMAL; CELL MEMBRANE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PROTEIN BINDING; SPRAGUE DAWLEY RAT;

ALLOSTERIC REGULATION; ANDROSTANES; ANIMALS; AZASTEROIDS; CELL MEMBRANE; CEREBRAL CORTEX; DESOXYCORTICOSTERONE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; MALE; PREGNANOLONE; PREGNENOLONE; PROTEIN BINDING; PYRIDAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; STEROIDS;

EID: 0030598578     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00090-8     Document Type: Article

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