Role of insulin and free fatty acids in the regulation of ob gene expression and plasma leptin in normal rats

Obesity Research

Volumn 12, Issue 12, 2004, Pages 2062-2069

  Pagano, Claudio ^a   Dorigo, Alberto ^a   Nisoli, Enzo ^b   Tonello, Cristina ^b   Calcagno, Alessandra ^a   Tami, Valeria ^a   Granzotto, Marnie ^a   Carruba, Michele O ^a   Federspil, Giovanni ^a   Vettor, Roberto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Adipose tissue; Free fatty acids; Insulin; Leptin; Rat

Indexed keywords

RATTUS;

DIAGNOSTIC AGENT; FATTY ACID; INSULIN; LEPTIN; MESSENGER RNA; SOMATOSTATIN;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; CHEMISTRY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; RAT; REGRESSION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZUCKER RAT;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE CLAMP TECHNIQUE; INSULIN; LEPTIN; RATS; RATS, ZUCKER; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SOMATOSTATIN;

EID: 18944394720     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2004.257     Document Type: Article

References (41)

1. Gregoire FM, Smas CM, Sook Sul H. Understanding adipocyte differentiation. Physiol Rev. 1998;78:783-809. (Pubitemid 28340604)
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32. (Pubitemid 24365442)
3. Mantzoros CS, Qu D, Frederich RC, et al. Activation of beta-3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes. 1996;45:909-14. (Pubitemid 26225507)
4. Gettys TW, Harkness PJ, Watson PM. The beta3 adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinology. 1996;137:4054-7. (Pubitemid 26284684)
5. Pagano C, Englaro P, Granzotto M, et al. Insulin induces rapid changes of plasma leptin in lean but not in genetically obese (fa/fa) rats. Int J Obes. 1997;21:614-8. (Pubitemid 27273510)
6. Saladin R, DeVos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake or insulin administration. Nature. 1995;377:527-9.
7. Trayhurn P, Duncan JS, Rayner DV, Hardie LJ. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta3-adrenoceptor agonist BRL 35135A and ZD2079. Biochem Biophys Res Commun. 1996;228:605-10. (Pubitemid 26396117)
8. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese subjects. New Engl J Med. 1996;334:292-5. (Pubitemid 26033933)
9. Maffei M, Haalas J, Ravussen E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1995;1: 1155-61.
10. Zheng D, Wooter MH, Zhou Q, Dohm GL. The effect of exercise on ob gene expression. Biochem Biophys Res Commun. 1996;225:747-50. (Pubitemid 26319177)
11. Pagano C, Marzolo M, Granzotto M, Ricquier D, Federspil G, Vettor R. Acute effects of exercise on circulating leptin in lean and genetically obese fa/fa rats. Biochem Biophys Res Commun. 1999;255:698-702. (Pubitemid 29294861)
12. Rentsch J, Chiesi M. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS lett. 1996;379:55-9. (Pubitemid 26033925)
13. Nisoli E, Vettor R, Tonello C, Macor C, Federspil G, Carruba MO. Nutrient channeling-regulated peroxisome proliferator-activated receptor-gamma-2 (PPARgamma-2) and leptin gene expression in human subcutaneous fat. Diabetologia. 1999;42:495-7. (Pubitemid 29148411)
14. Fabris R, Nisoli E, Lombardi AM, et al. Preferential channeling of energy fuels toward fat rather than muscle during high free fatty acid availability in rats. Diabetes. 2001;50: 601-8. (Pubitemid 32195225)
15. Terrettaz J, Jeanrenaud B. In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology. 1983;112:1346-51.
16. Jeanrenaud B, Rohner-Jeanrenaud F. Effects of neuropeptides and leptin on nutrient partitioning: dysregulations in obesity. Annu Rev Med. 2001;52:339-51. (Pubitemid 32195329)
17. Muoio DM, Dohm GL, Tapscott EB, Coleman RA. Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. Am J Physiol. 1999;276:E913-21. (Pubitemid 29249611)
18. Weigle DS, Selfridge LE, Schwartz MW, et al. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes. 1998;47:298-302. (Pubitemid 28079993)
19. Latruffe N, Malki MC, Nicolas-Frances V, Clemencet MC, Jannin B, Berlot JP. Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases. Biochem Pharmacol. 2000; 60:1027-32.
20. Fruchart JC, Duriez P, Staels B. Peroxisome proliferatoractivated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol. 1999;10:245-57. (Pubitemid 29405915)
21. Dreyer C, Keller H, Mahfoudi A, Laudet V, Krey G, Wahli W. Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol Cell. 1993;77:67-76. (Pubitemid 23135586)
22. Stefan N, Fritsche A, Haring H, Stumvoll M. Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting. Int J Obes. 2001;25:138-42. (Pubitemid 32142396)
23. Worm D, Vinten J, Henriksen JE, Beck-Nielsen H. The nicotinic acid analogue acipimox increases plasma leptin and decreases free fatty acids in type 2 diabetic patients. Eur J Endocr. 2000;143:389-95.
24. Roh C, Thoidis G, Farmer SR, Kandror KV. Identification and characterization of leptin-containing intracellular compartment in rat adipose cells. Am J Physiol. 2000;279:E893-9.
25. Bradley RL, Cheatham B. Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes. 1999;48:272-8. (Pubitemid 29061098)
26. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature. 1998;393:684-8. (Pubitemid 28289657)
27. Flier JS. Leptin expression and action: new experimental paradigm. Proc Natl Acad Sci USA. 1998;94:4242-5.
28. Bai Y, Zhang S, Kim KS, Lee JK, Kim KH. Leptin inhibits acetyl-CoA carboxylase in 3T3 pre-adipocytes. J Biol Chem. 1996;271:13939-42.
29. Fruhbeck G, Aguado M, Martinez JA. In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Comm. 1997;240:590-4. (Pubitemid 28271762)
30. Ceddia RB, William WN Jr, Curi R. The response of skeletal muscle to leptin. Front Biosci. 2001;6:D90-7.
31. Unger RH. Weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology. 2003;144:5159-65. (Pubitemid 37476041)
32. Pagano C, Macor C, Englaro P, et al. Does insulin regulate circulating leptin? Studies in rats and humans. In: Blum WF, Kiess W, Rascher W, eds. Leptin, the Voice of Adipose Tissue. Barth Verlag Edition J&J; Heidelberg, Germany, 1997, pp. 83-92.
33. Fan X, Bradbury MW, Berk PD. Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes. J Nutr. 2003;133:2707-15. (Pubitemid 37099749)
34. Berk PD, Zhou S, Kiang C, Stump DD, Fan X, Bradbury MW. Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J Biol Chem. 1999;274:28626-31.
35. Berk PD, Zhou SL, Kiang CL, Stump D, Bradbury M, Isola LM. Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. J Biol Chem. 1997;272:8830-5. (Pubitemid 27147855)
36. Remesar X, Rafecas I, Fernandez-Lopez JA, Alemany M. Is leptin an insulin counter-regulatory hormone? FEBS Lett. 1997;402:9-11. (Pubitemid 27056013)
37. Torbay N, Bracco EF, Geliebter A, Stewart IM, Hashim SA. Insulin increases body fat despite control of food intake and physical activity. Am J Physiol. 1985;248:R120-4. (Pubitemid 15172502)
38. Fain JN, Kovacev VP, Scow RO. Antilipolytic effect of insulin in isolated fat cells of the rat. Endocrinology. 1966; 78:773-8.
39. William WN Jr., Ceddia RB, Curi R. Leptin controls the fate of fatty acids in isolated rat white adipocytes. J Endocrinol. 2002;175:735-44. (Pubitemid 36061173)
40. Zhou YT, Wang ZW, Higa M, Newgard CB, Unger RH. Reversing adipocyte differentiation: implications for treatment of obesity. Proc Natl Acad Sci USA. 1999;96: 2391-5. (Pubitemid 29117925)
41. Friedman JM. Leptin and the regulation of body weight. Harvey Lect. 1999;95:107-36.