Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine

European Journal of Medicinal Chemistry

Volumn 40, Issue 5, 2005, Pages 452-466

  Venkatachalam, T K ^a   Samuel, P ^a   Qazi, S ^a   Uckun, F M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Distereoisomers; HIV; Hydrolysis; Mechanism; Proteases; Stampidine

Indexed keywords

ANTIVIRUS AGENT; ESTER DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHORUS; PRODRUG; PROTEINASE; STAVUDINE; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG ACTIVATION; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; PROTEINASE INHIBITION; STEREOCHEMISTRY; SUBSTITUTION REACTION; VIRUS INACTIVATION; VIRUS INHIBITION;

AMIDES; BIOTRANSFORMATION; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE HYDROLASES; PHOSPHORIC ACIDS; PRODRUGS; SPECTROPHOTOMETRY, ULTRAVIOLET; STAVUDINE; STEREOISOMERISM; THYMIDINE MONOPHOSPHATE;

EID: 18944371086     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.11.015     Document Type: Article

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