MHC class II molecules traffic into lipid rafts during intracellular transport

Journal of Immunology

Volumn 173, Issue 7, 2004, Pages 4539-4546

  Poloso, Neil J ^a   Muntasell, Aura ^a   Roche, Paul A ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUPEPTIN; LIPID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONENSIN; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; ISOTOPE LABELING; LIPID RAFT; LYSOSOME MEMBRANE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN TRANSPORT; T LYMPHOCYTE ACTIVATION;

EID: 4644294133     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.7.4539     Document Type: Article

References (39)

1. Hording, C. V., and E. R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346:574.
2. Demote, S., H. M. Grey, and A. Sette. 1990. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 249:1028.
3. Reay, P. A., K. Matsui, K. Haase, C. Wulfing, Y. H. Chien, and M. M. Davis. 2000. Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies. J. Immunol. 164:5626.
4. Edidin, M. 2003. The state of lipid rafts: from model membranes to cells. Annu. Rev. Biophys. Biomol. Struct. 32:257.
5. Setterblad, N., S. Becart, D. Charron, and N. Mooney. 2001. Signalling via MHC class II molecules modifies the composition of OEMs in APC. Scand. J. Immunol. 54:87.
6. + T cells engaging class II molecules in cholesterol-rich domains. J. Immunol. 168:1172.
7. Huby, R. D., R. J. Dearman, and I. Kimber. 1999. Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J. Biol. Chem. 274:22591.
8. Goebel, J., K. Forrest, D. Flynn, R. Rao, and T. L. Roszman. 2002. Lipid rafts, major histocompatibility complex molecules, and immune regulation. Hum. Immunol. 63:813.
9. Buatois, V., M. Baillet, S. Becart, N. Mooney, L. Leserman, and P. Machy. 2003. MHC class II-peptide complexes in dendritic cell lipid microdomains initiate the CD4 Th1 phenotype. J. Immunol. 171:5812.
10. Bouillon, M., Y. El Fakhry, J. Girouard, H. Khalil, J. Thibodeau, and W. Mourad. 2003. Lipid raft-dependent and -independent signaling through HLA-DR molecules. J. Biol. Chem. 278:7099.
11. Anderson, H. A., E. M. Hiltbold, and P. A. Roche. 2000. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 1:156.
12. Becart, S., N. Setterblad, S. Ostrand-Rosenberg, S. J. Ono, D. Charron, and N. Mooney. 2003. Intracytoplasmic domains of MHC class II molecules are essential for lipid-raft-dependent signaling. J. Cell Sci. 116:2565.
13. Hiltbold, E. M., N. J. Poloso, and P. A. Roche. 2003. MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J. Immunol. 170:1329.
14. Hiltbold, E. M., and P. A. Roche. 2002. Trafficking of MHC class II molecules in the late secretory pathway. Curr. Opin. Immunol. 14:30.
15. Blum, J. S., and P. Cresswell. 1988. Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc. Natl. Acad. Sci. USA 85:3975.
16. Jensen, P. E., D. A. Weber, W. P. Thayer, L. E. Westerman, and C. T. Dao. 1999. Peptide exchange in MHC molecules. Immunol. Rev. 172:229.
17. Busch, R., R. C. Doebele, N. S. Patil, A. Pashine, and E. D. Mellins. 2000. Accessory molecules for MHC class II peptide loading. Curr. Opin. Immunol. 12:99.
18. Chow, A., D. Toomre, W. Garrett, and I. Mellman. 2002. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 418:988.
19. Boes, M., J. Cerny, R. Massol, M. Op den Brouw, T. Kirchhausen, J. Chen, and H. L. Ploegh. 2002. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418:983.
20. Roche, P. A., C. L. Teletski, E. Stang, O. Bakke, and E. O. Long. 1993. Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization. Proc. Natl. Acad. Sci. USA 90:8581.
21. Anderson, H. A., and P. A. Roche. 1998. Phosphorylation regulates the delivery of MHC class II invariant chain complexes to antigen processing compartments. J. Immunol. 160:4850.
22. Pierre, P., L. K. Denzin, C. Hammond, J. R. Drake, S. Amigorena, P. Cresswell, and I. Mellman. 1996. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments. Immunity 4:229.
23. Machamer, C. E., and P. Cresswell. 1984. Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the α-β chain complex. Proc. Natl. Acad. Sci. USA 81:1287.
24. Setterblad, N., C. Roucard, C. Bocaccio, J. P. Abastado, D. Charron, and N. Mooney. 2003. Composition of MHC class II-enriched lipid microdomains is modified during maturation of primary dendritic cells. J. Leukocyte Biol. 74:40.
25. Warmerdam, P. A., E. O. Long, and P. A. Roche. 1996. Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments. J. Cell Biol. 133:281.
26. Neefjes, J. J., and H. L. Ploegh. 1992. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance αβ heterodimers in endosomes. EMBO J. 11:411.
27. Loss, G. E., Jr., and A. J. Sant. 1993. Invariant chain retains MHC class II molecules in the endocytic pathway. J. Immunol. 150:3187.
28. Newcomb, J. R., and P. Cresswell. 1993. Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated αβ dimers. J. Immunol. 150:499.
29. Jensen, P. E., D. A. Weber, W. P. Thayer, X. Chen. and C. T. Dao. 1999. HLA-DM and the MHC class II antigen presentation pathway, Immunol. Res. 20:195.
30. Kropshofer, H., G. J. Hammerling, and A. B. Vogt. 1999. The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules, Immunol. Rev. 172:267.
31. Brown, D. A., and J. K. Rose. 1992. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68:533.
32. Mobius, W., Y. Ohno-Iwashita, E. G. van Donselaar, V. M. Oorschot, Y. Shimada, T. Fujimoto, H. F. Heijnen, H. J. Geuze, and J. W. Slot. 2002. Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O. J. Histochem. Cytochem. 50:43.
33. Benaroch, P., M. Yilla, G. Raposo, K. Ito, K. Miwa, H. J. Geuze, and H. L. Ploegh. 1995. How MHC class II molecules reach the endocytic pathway, EMBO J. 14:37.
34. + compartments in dendritic cells. J. Immunol. 171:5689.
35. Dolan, B. P., T. P. Phelan, D. Ilkovitch, L. Qi, W. F. Wade, T. M. Laufer, and S. Ostrand-Rosenberg. 2004. Invariant chain and the MHC class II cytoplasmic domains regulate localization of MHC class II molecules to lipid rafts in tumor cell-based vaccines. J. Immunol. 172:907.
36. Pralle, A., P. Keller, E. L. Florin, K. Simons, and J. K. Horber. 2000. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J. Cell Biol. 148:997.
37. Sharma, P., R. Varma, R. C. Sarasij, Ira, K. Gousset, G. Krishnamoorthy, M. Rao, and S. Mayor. 2004. Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. Cell 116:577.
38. + T cell priming by dendritic cells in intact lymph nodes. Nat. Immunol. 4:579.
39. Dustin, M. L., S. K. Bromley, Z. Kan, D. A. Peterson, and E. R. Unanue. 1997. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl. Acad. Sci. USA 94:3909.