Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2

Differentiation

Volumn 73, Issue 1, 2005, Pages 18-27

  Martin, Suzanna E ^a,b   Mu, Xiuqian ^a,b   Klein, William H ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Brn3b POU4f2; POU domain transcription factors; Retinal ganglion cell differentiation; Transcription activation domains

Indexed keywords

LEXA PROTEIN; LUCIFERASE; PLASMID VECTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR POU4F2; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; DNA; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; LEXA PROTEIN, BACTERIA; POU4F1 PROTEIN, MOUSE; POU4F2 PROTEIN, MOUSE; SERINE PROTEINASE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR POU4; TRANSCRIPTION FACTOR POU4F1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE CONTROL; GENE REPRESSION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REPORTER GENE; RETINA GANGLION CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; BINDING SITE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; TRANSACTIVATION;

ANIMALIA;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CELL DIFFERENTIATION; CELLS, CULTURED; CRICETINAE; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HERPES SIMPLEX VIRUS PROTEIN VMW65; HOMEODOMAIN PROTEINS; LUCIFERASES; MICE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RETINAL GANGLION CELLS; SERINE ENDOPEPTIDASES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR BRN-3; TRANSCRIPTION FACTOR BRN-3A; TRANSCRIPTION FACTOR BRN-3B; TRANSCRIPTION FACTORS;

EID: 18844427802     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1111/j.1432-0436.2005.07301004.x     Document Type: Article

References (28)

1. Andersen, B. and Rosenfeld, M.G. (2001) POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocrine Rev 22:2-35.
2. Baumeister, R., Liu, Y. and Ruvkun, G. (1996) Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev 10:395-410.
3. Budhram-Mahadeo, V., Morris, P.J., Lakin, N.D., Theil, T., Ching, G.V., Lillycrop, K.A., Moroy, T., Liem, R.K. and Latchman, D.S. (1995) Activation of the alpha-internexin promoter by the Brn-3a transcription factor is dependent on the N-terminal region of the protein. J Biol Chem 270:2853-2858.
4. Budhram-Mahadeo, V., Ndisang, D., Ward, T., Weber, B.L. and Latchman, D.S. (1999) The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells. Oncogene 18:6684-6691.
5. Erkman, L., McEvilly, R.J., Luo, L., Ryan, A.K., Hooshmand, F., O'Connell, S.M., Keithley, E.M., Rapaport, D.H., Ryan, A.F. and Rosenfeld, M.G. (1996) Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature 381:603-606.
6. Erkman, L., Yates, P.A., McLaughlin, T., McEvilly, R.J., Whisenhunt, T., O'Connell, S.M., Krones, A.I., Kirby, M.A., Rapaport, D.H., Bermingham, J.R., O'Leary, D.D. and Rosenfeld, M.G. (2000) A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron 28:779-792.
7. Gan, L., Wang, S.W., Huang, Z. and Klein, W.H. (1999) POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol 210:469-480.
8. Gan, L., Xiang, M., Zhou, L., Wagner, D.S., Klein, W.H. and Nathans, J. (1996) POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci USA 93:3920-3925.
9. Gottlieb, P.D., Pierce, S.A., Sims, R.J., Yamagishi, H., Weihe, E.K., Harriss, J.V., Maika, S.D., Kuziel, W.A., King, H.L., Olson, E.N., Nakagawa, O. and Srivastava, D. (2002) Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet 31:25-32.
10. Gruber, C.A., Rhee, J.M., Gleiberman, A. and Turner, E.E. (1997) POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution. Mol Cell Biol 17:2391-2400.
11. Lee, T., Bradley, M.E. and Walowitz, J.L. (1998) Influence of promoter potency on the transcriptional effects of YY1, SRF and Msx-1 in transient transfection analysis. Nucleic Acids Res 26:3215-3220.
12. Liu, W., Khare, S.L., Liang, X., Peters, M.A., Liu, X., Cepko, C.L. and Xiang, M. (2000) All Brn3 genes can promote retinal ganglion cell differentiation in the chick. Development 127: 3237-3247.
13. McEvilly, R.J., Erkman, L., Luo, L., Sawchenko, P.E., Ryan, A.F. and Rosenfeld, M.G. (1996) Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384:574-577.
14. Molkentin, J.D., Black, B.L., Martin, J.F. and Olson, E.N. (1995) Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH factors. Cell 83:125-136.
15. Morris, P.J., Lakin, N.D., Dawson, S.J., Ryabinin, A.E., Kilimann, M.W., Wilson, M.C. and Latchman, D.S. (1996) Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. Mol Brain Res 43:279-285.
16. Mu, X., Beremand, P.D., Zhao, S., Pershad, R., Sun, H., Scarpa, A., Liang, S., Thomas, T.L. and Klein, W.H. (2004) Discrete gene sets depend on POU domain transcription factor Brn3b/ Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development 131:1197-1210.
17. Mu, X., Zhao, S., Pershad, R., Hsieh, T.F., Scarpa, A., Wang, S.W., White, R.A., Beremand, P.D., Thomas, T.L., Gan, L. and Klein, W.H. (2001) Gene expression in the developing mouse retina by EST screening and microarray analysis. Nucleic Acids Res 29:4983-4993.
18. Pan, L., Yang, Z., Feng, L. and Gan, L. (2005) Functional equivalence of Brn-3 POU-domain transcription factors in mouse retinal neurogenesis. Development 32:703-712.
19. Pessac, B., Girard, A., Romney, G., Crisanti, P., Lorinet, A.M. and Calothy, G. (1983a) A neuronal clone derived from a Rous sarcoma virus-transformed quail embryo neuroretina established culture. Nature 302:616-618.
20. Pessac, B., Girard, A., Romey, G., Crisanti, P., Wassef, M., Privat, A. and Calothy, G. (1983b) Cells with neuronal properties in permanent cultures of quail embryo neuroretinas infected with Rous sarcoma virus. Brain Res 275:53-59.
21. Plaza, S., Hennemann, H., Moroy, T., Saule, S. and Dozier, C. (1999) Evidence that POU factor Brn-3B regulates expression of Pax-6 in neuroretina cells. J Neurobiol 41:349-358.
22. Rockelein, I., Rohrig, S., Donhauser, R., Eimer, S. and Baumeister, R. (2000) Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC3-DNA ternary complex formation. Mol Cell Biol 20: 4806-4813.
23. Trieu, M., Ma, A., Eng, S.R., Fedtsova, N. and Turner, E.E. (2003) Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a. Development 130:111-121.
24. Trieu, M., Rhee, J.M., Fedtsova, N. and Turner, E.E. (1999) Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus. J Neurosci 19:6549-6558.
25. Wang, S.W., Gan, L., Martin, S.E. and Klein, W.H. (2000) Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b. Mol Cell Neurosci 16:141-156.
26. Wang, S.W., Mu, X., Bowers, W.J., Kim, D.S., Plas, D.J., Crair, M.C., Federoff, H.J., Gan, L. and Klein, W.H. (2002) Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 129:467-477.
27. Xiang, M., Gan, L., Li, D., Zhou, L., Chen, Z.Y., Wagner, D., O'Malley, B.W., Jr., Klein, W. and Nathans, J. (1997) Role of the Brn3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb Symp Quant Biol 62:325-336.
28. Xiang, M., Gao, W.Q., Hasson, T. and Shin, J.J. (1998) Requirement for Brn-3c in maturation and survival, but not fate determination of inner ear hair cells. Development 125: 3935-3946.