Smad1 expression and function during mouse embryonic lung branching morphogenesis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 288, Issue 6 32-6, 2005, Pages

  Chen, Cheng ^a,c   Chen, Hui ^b   Sun, Jianping ^a   Bringas Jr , Pablo ^b   Chen, Yuhua ^c   Warburton, David ^a   Shi, Wei ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Bone morphogenetic protein 4; Lung development

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; CLARA CELL PROTEIN; LIGAND; MESSENGER RNA; MOLECULAR MARKER; SMAD1 PROTEIN; SURFACTANT PROTEIN C;

ANIMAL TISSUE; ARTICLE; BRANCHING MORPHOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOTHELIUM CELL; EPITHELIUM CELL; EXPLANT; IMMUNOHISTOCHEMISTRY; LUNG DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SMOOTH MUSCLE FIBER; UBIQUITINATION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA-BINDING PROTEINS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LUNG; MESODERM; MICE; MORPHOGENESIS; MYOCYTES, SMOOTH MUSCLE; OLIGONUCLEOTIDES, ANTISENSE; PREGNANCY; SMAD PROTEINS; SMAD1 PROTEIN; TRANS-ACTIVATORS;

EID: 18844407494     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00277.2004     Document Type: Article

References (29)

1. Bellusci S, Henderson R, Winnier G, Oikawa T, and Hogan BL. Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122: 1693-1702, 1996.
2. Bragg AD, Moses HL, and Serra R. Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor beta and bone morphogenetic protein 4 on murine embryonic lung development. Mech Dev 109: 13-26, 2001.
3. Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, and Zwijsen A. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126: 1631-1642, 1999.
4. Chang H, Zwijsen A, Vogel H, Huylebroeck D, and Matzuk MM. Smad5 is essential for left-right asymmetry in mice. Dev Biol 219: 71-78, 2000.
5. Derynck R and Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003.
6. Dick A, Risau W, and Drexler H. Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development. Dev Dyn 211: 293-305, 1998.
7. Have-Opbroek AA. Lung development in the mouse embryo. Exp Lung Res 17: 111-130, 1991.
8. Hogan BL. Bone morphogenetic proteins in development. Curr Opin Genet Dev 6: 432-438, 1996.
9. Hogan BL. Morphogenesis. Cell 96: 225-233, 1999.
10. Hogan BL, Grindley J, Bellusci S, Dunn NR, Emoto H, and Itoh N. Branching morphogenesis of the lung: new models for a classical problem. Cold Spring Harb Symp Quant Biol 62: 249-256, 1997.
11. Huang S, Flanders KC, and Roberts AB. Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues. Gene 258: 43-53, 2000.
12. Jaskoll TF, Don-Wheeler G, Johnson R, and Slavkin HC. Embryonic mouse lung morphogenesis and type II cytodifferentiation in serumless, chemically defined medium using prolonged in vitro cultures. Cell Differ 24: 105-117, 1988.
13. Jeffery TK, Upton PD, Trembath RC, and Morrell NW. BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. Am J Physiol Lung Cell Mol Physiol 288: L370-L378, 2005.
14. Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, and Burgess AW. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 284: 31-53, 2003.
15. Lechleider RJ, Ryan JL, Garrett L, Eng C, Deng C, Wynshaw-Boris A, and Roberts AB. Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion. Dev Biol 240: 157-167, 2001.
16. Massague J and Chen YG. Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000.
17. Pera EM, Ikeda A, Eivers E, and De Robertis EM. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev 17: 3023-3028, 2003.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45, 2001.
19. Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, and Roberts AB. Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 276: 19945-19953, 2001.
20. Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG, and Warburton D. TACE is required for fetal murine cardiac development and modeling. Dev Biol 261: 371-380, 2003.
21. Shi W, Chen H, Sun J, Chen C, Zhao J, Wang YL, Anderson KD, and Warburton D. Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol 286: L293-L300, 2004.
22. Shi W, Zhao J, Anderson KD, and Warburton D. Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis. Am J Physiol Lung Cell Mol Physiol 280: L1030-L1039, 2001.
23. Tremblay KD, Dunn NR, and Robertson EJ. Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development 128: 3609-3621, 2001.
24. Warburton D, Bellusci S, Del Moral PM, Kaartinen V, Lee M, Tefft D, and Shi W. Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res 4: 5, 2003.
25. Warburton D, Seth R, Shum L, Horcher PG, Hall FL, Werb Z, and Slavkin HC. Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis. Dev Biol 149: 123-133, 1992.
26. Weaver M, Dunn NR, and Hogan BL. Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development 127: 2695-2704, 2000.
27. Zhang J, O'Shea S, Liu J, and Schuger L. Bronchial smooth muscle hypoplasia in mouse embryonic lungs exposed to a laminin beta1 chain antisense oligonucleotide. Mech Dev 89: 15-23, 1999.
28. Zhao J, Shi W, Chen H, and Warburton D. Smad7 and Smad6 differentially modulate transforming growth factor beta-induced inhibition of embryonic lung morphogenesis. J Biol Chem 275: 23992-23997, 2000.
29. Zhu H, Kavsak P, Abdollah S, Wrana JL, and Thomsen GH. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400: 687-693, 1999.