Mechanical unfolding of a titin Ig domain: Structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering

Journal of Molecular Biology

Volumn 322, Issue 4, 2002, Pages 841-849

  Fowler, Susan B ^a   Best, Robert B ^a   Toca Herrera, José L ^a   Rutherford, Trevor J ^a   Steward, Annette ^a   Paci, Emanuele ^b   Karplus, Martin ^b,c   Clarke, Jane ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Fibronectin type III; Force microscopy; Immunoglobulin; Protein folding; Titin

Indexed keywords

CONNECTIN; IMMUNOGLOBULIN; MUTANT PROTEIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; COMPARATIVE STUDY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STABILITY; SIMULATION; WILD TYPE;

EID: 0036389817     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00805-7     Document Type: Article

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