Determinants of antagonist binding at the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, gluR-D: Role of the conserved arginine 507 and glutamate 727 residues

European Journal of Biochemistry

Volumn 269, Issue 24, 2002, Pages 6261-6270

  Jouppila, Annukka ^a   Pentikäinen, Olli T ^b   Settimo, Luca ^b   Nyrönen, Tommi ^c   Haapalahti, Jukka Pekka ^a   Lampinen, Milla ^a   Mottershead, David G ^a   Johnson, Mark S ^b   Keinänen, Kari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c IT Center for Science   (Finland)

Author keywords

AMPA; Ionotropic glutamate receptor; Molecular modelling; Radioligand binding; Ro 48 8587

Indexed keywords

7,7 DINITROQUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR; QUINOXALINE DERIVATIVE; RADIOLIGAND; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; ELECTRICITY; HYDROGEN BOND; LIGAND BINDING; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION;

ANIMALS; ARGININE; BINDING SITES; BLOTTING, WESTERN; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; IMIDAZOLES; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; RATS; RECEPTORS, GLUTAMATE;

ANIMALIA;

EID: 18744394305     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03345.x     Document Type: Article

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