Arginine-481 mutation abolishes ligand-binding of the AMPA-selective glutamate receptor channel α1-subunit

Molecular Brain Research

Volumn 47, Issue 1-2, 1997, Pages 339-344

  Kawamoto, Susumu ^a   Uchino, Shigeo ^b   Xin, Ke Qin ^a   Hattori, Satoshi ^a   Hamajima, Kenji ^a   Fukushima, Jun ^a   Mishina, Masayoshi ^c   Okuda, Kenji ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

1 subunit; Agonist binding site; AMPA receptor; Baculovirus; Glutamate receptor channel; Insect cell; Ion channel; Site directed mutagenesis

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; ARGININE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLUTAMINE; ION CHANNEL; LYSINE; MEMBRANE PROTEIN; RECEPTOR SUBUNIT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BACULOVIRUS; BINDING SITE; CONTROLLED STUDY; GENE MUTATION; IMMUNOBLOTTING; ISOTOPE LABELING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ARGININE; BASE SEQUENCE; ION CHANNELS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; RADIOLIGAND ASSAY; RECEPTORS, GLUTAMATE;

INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 0030787872     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00103-4     Document Type: Article

References (29)

1. K. Araki, H. Meguro, E. Kushiya, C. Takayama, Y. Inoue, M. Mishina, Selective expression of the glutamate receptor channel δ2 subunit in cerebellar Purkinje cells, Biochem. Biophys. Res. Commun. 197 (1993) 1267-1276.
2. M. Arvola, K. Keinänen, Characterization of the ligand-binding domains of glutamate receptor (GluR)-B and GluR-D subunits expressed in Escherichia coli as periplasmic proteins, J. Biol. Chem. 271 (1996) 15527-15532.
3. B. Bettler, J. Egebjerg, G. Sharma, G. Pecht, I. Hermans-Borgmeyer, C. Moll, C.F. Stevens, S. Heinemann, Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit, Neuron 8 (1992) 257-265.
4. B. Bettler, C. Mulle, AMPA and kainate receptors, Neuropharmacology 34 (1995) 123-139.
5. A.M. Ciabarra, J.M. Sullivan, L.G. Gahn, G. Pecht, S. Heinemann, K.A. Sevarino, Cloning and characterization of χ-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family, J. Neurosci. 15 (1995) 6498-6508.
6. R.M. Duvoisin, C. Zhang, K. Ramonell, A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb, J. Neurosci. 15 (1995) 3075-3083.
7. S. Hattori, K. Okuda, K. Hamajima, K. Sakimura, M. Mishina, S. Kawamoto, Expression and characterization of the α2 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptor channel in a baculovirus system, Brain Res. 666 (1994) 43-52.
8. H. Hirai, J. Kirsch, B. Laube, H. Betz, J. Kuhse, The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region, Proc. Natl. Acad. Sci. USA 93 (1996) 6031-6036.
9. S. Kawamoto, H. Onishi, S. Hattori, Y. Miyagi, Y. Amaya, M. Mishina, K. Okuda, Functional expression of the α1 subunit of the AMPA-selective glutamate receptor channel, using a baculovirus system, Biochem. Biophys. Res. Commun. 181 (1991) 756-763.
10. S. Kawamoto, S. Hattori, I. Oiji, A. Ueda, J. Fukushima, K. Sakimura, M. Mishina, K. Okuda, Expression of the α1 and α2 subunits of the AMPA-selective glutamate receptor channel in insect cells using a baculovirus vector, Ann. NY Acad. Sci. 707 (1993) 460-462.
11. S. Kawamoto, S. Hattori, I. Oiji, K. Hamajima, M. Mishina, K. Okuda, Ligand-binding properties and N-glycosylation of α1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)-selective glutamate receptor channel expressed in a baculovirus system, Eur. J. Biochem. 223 (1994) 665-673.
12. S. Kawamoto, S. Hattori, K. Sakimura, M. Mishina, K. Okuda, N-Linked glycosylation of the α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-selective glutamate receptor channel α2 subunit is essential for the acquisition of ligand-binding activity, J. Neurochem. 64 (1995) 1258-1266.
13. S. Kawamoto, S. Uchino, S. Hattori, K. Hamajima, M. Mishina, S. Nakajima-Iijima, K. Okuda, Expression and characterization of the ζ1 subunit of the N-methyl-D-aspartate (NMDA) receptor channel in a baculovirus system, Mol. Brain. Res. 30 (1995) 137-148.
14. S.J. Kendrick, D.R. Lynch, D.B. Pritchett, Characterization of glutamate binding sites in receptors assembled from transfected NMDA receptor subunits, J. Neurochem. 67 (1996) 608-616.
15. A. Kuusinen, M. Arvola, K. Keinänen, Molecular dissection of the agonist binding site of an AMPA receptor, EMBO J. 14 (1995) 6327-6332.
16. F. Li, N. Owens, T.A. Verdoorn, Functional effects of mutations in the putative agonist binding region of recombinant α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, Mol. Pharmacol. 47 (1995) 148-154.
17. I. Mano, Y. Lamed, V.I. Teichberg, A venus flytrap mechanism for activation and desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors, J. Biol. Chem. 271 (1996) 15299-15302.
18. R.A.J. McIlhinney, E. Molnár, Characterization, cell-surface expression and ligand-binding properties of different truncated N-terminal extracellular domains of the ionotropic glutamate receptor subunit GluR1, Biochem. J. 315 (1996) 217-225.
19. H. Mori, M. Mishina, Structure and function of the NMDA receptor channel, Neuropharmacology 34 (1995) 1219-1237.
20. B.-H. Oh, J. Pandit, C.-H. Kang, K. Nikaido, S. Gokcen, G.F.-L. Ames, S.-H. Kim, Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand, J. Biol. Chem. 268 (1993) 11348-11355.
21. P.J. O'Hara, P.O. Sheppard, H. Thøgersen, D. Venezia, B.A. Haldeman, V. McGrane, K.M. Houamed, C. Thomsen, T.L. Gilbert, E.R. Mulvihill, The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins, Neuron 11 (1993) 41-52.
22. J.-P. Pin, R. Duvoisin, The metabotropic glutamate receptors: structure and functions, Neuropharmacology 34 (1995) 1-26.
23. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism, Cell 75 (1993) 1297-1303.
24. Y. Stern-Bach, B. Bettler, M. Hartley, P.O. Sheppard, P.J. O'Hara, S.F. Heinemann, Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins, Neuron 13 (1994) 1345-1357.
25. N.J. Sucher, S. Akbarian, C.L. Chi, C.L. Leclerc, M. Awobuluyi, D.L. Deitcher, M.K. Wu, J.P. Yuan, E.G. Jones, S.A. Lipton, Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain, J. Neurosci. 15 (1995) 6509-6520.
26. M.J. Sutcliffe, Z.G. Wo, R.E. Oswald, Three-dimensional models of non-NMDA glutamate receptors, Biophys. J. 70 (1996) 1575-1589.
27. S. Uchino, K. Sakimura, K. Nagahari, M. Mishina, Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel, FEBS Lett. 308 (1992) 253-257.
28. S. Uchino, S. Nakajima-Iijima, K. Okuda, M. Mishina, S. Kawamoto, Analysis of the glycine binding domain of the NMDA receptor channel ζ1 subunit, NeuroReport 8 (1997) 445-450.
29. K.A. Wafford, M. Kathoria, C.J. Bain, G. Marshall, B. Le Bourdellès, J.A. Kemp, P.J. Whiting, Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site, Mol. Pharmacol. 47 (1995) 374-380.