Discrimination between agonists and antagonists by the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor: A mutation analysis of the ligand-binding domain of GluR-D subunit

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 41940-41947

  Lampinen, Milla ^a   Settimo, Luca ^b   Pentikäinen, Olli T ^b   Jouppila, Annukka ^c   Mottershead, David G ^b   Johnson, Mark S ^b   Keinänen, Kari ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOASSAY; CELLS; CRYSTAL STRUCTURE; MUTAGENESIS; ORGANIC ACIDS;

AGONIST COMPLEXES;

ENZYMES;

6,7 DINITRO 2,3 QUINOXALINEDIONE; 9 IMIDAZOL 1 YL 8 NITRO 2,3,5,6 TETRAHYDRO[1,2,4]TRIAZOLO[1,5 C]QUINAZOLINE 2,5 DIONE; ALANINE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; AMPA RECEPTOR ANTAGONIST; GLUTAMATE RECEPTOR; LIGAND; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SUBUNIT; INSECT CELL; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MOLECULAR STABILITY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR BLOCKING; SITE DIRECTED MUTAGENESIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; BACULOVIRIDAE; BINDING SITES; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; IMIDAZOLES; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; QUINAZOLINES; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP;

INSECTA;

EID: 0036830592     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205242200     Document Type: Article

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