Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 8, 1996, Pages 1682-1691

  Madsen, Ulf ^a   Bang Andersen, Benny ^b   Brehm, Lotte ^a   Christensen, Inge T ^a   Ebert, Bjarke ^a   Kristoffersen, Inge T S ^a   Lang, Yolande ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 [3 (CARBOXYMETHOXY) 5 METHYL 4 ISOXAZOLYL]PROPIONIC ACID; 2 AMINO 3 [5 TERT BUTYL 3 (CARBOXYMETHOXY) 4 ISOXAZOLYL]PROPIONIC ACID; 2 AMINO 3 [5 TERT BUTYL 3 (PHOSPHONOMETHOXY) 4 ISOXAZOLYL]PROPIONIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; CARBOXYLIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; NERVE DEGENERATION; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; ISOXAZOLES; RATS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029863920     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950826p     Document Type: Article

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