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Volumn 71, Issue 4, 2005, Pages 287-294

Dietary phytoestrogens: Potential selective estrogen enzyme modulators?

Author keywords

Aromatase; Endocrine disrupters; Hydroxysteroid dehydrogenases; Phytoestrogens; Sulfatase; Sulfotransferases

Indexed keywords

APIGENIN; AROMATASE; AURANTIIN; BIOCHANIN A; CATECHIN; CHRYSIN; COUMESTROL; DAIDZEIN; DAIDZEIN 4' O SULFATE; DAIDZEIN 4',7 DI O SULFATE; DAIDZEIN 7 O SULFATE; ENTERODIOL; ENTEROLACTONE; ENZYME INHIBITOR; EQUOL; ERIODICTYOL; ERODICTYOL; FLAVONOID; FORMONONETIN; GALLOCATECHIN; GENISTEIN; GENISTEIN 7 O SULFATE; HESPERETIN; ISOFLAVONOID; KAEMPFEROL; LIGNAN DERIVATIVE; LUTEOLIN; NARINGENIN; PHYTOESTROGEN; QUERCETIN; RESVERATROL; SELECTIVE ESTROGEN ENZYME MODULATOR; STEROID; SULFATASE; SULFOTRANSFERASE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

EID: 18744389481     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-864092     Document Type: Review
Times cited : (50)

References (89)
  • 1
    • 0032994684 scopus 로고    scopus 로고
    • Phytoestrogens: The "natural" selective estrogen receptor modulators?
    • Brzezinski A, Debi A. Phytoestrogens: the "natural" selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol 1999; 85: 47-51
    • (1999) Eur J Obstet Gynecol Reprod Biol , vol.85 , pp. 47-51
    • Brzezinski, A.1    Debi, A.2
  • 2
    • 4444267529 scopus 로고    scopus 로고
    • Local biosynthesis and metabolism of estrogens in the human breast
    • Thijssen JHH. Local biosynthesis and metabolism of estrogens in the human breast. Maturitas 2004; 49: 25-33
    • (2004) Maturitas , vol.49 , pp. 25-33
    • Thijssen, J.H.H.1
  • 3
    • 0034982135 scopus 로고    scopus 로고
    • The selective estrogen enzyme modulator (SEEM) in breast cancer
    • Chetrite GS, Pasqualini JR. The selective estrogen enzyme modulator (SEEM) in breast cancer. J Steroid Biochem Molec Biol 2001; 76: 95-104
    • (2001) J Steroid Biochem Molec Biol , vol.76 , pp. 95-104
    • Chetrite, G.S.1    Pasqualini, J.R.2
  • 4
    • 2542492928 scopus 로고    scopus 로고
    • The selective estrogen enzyme modulators in breast cancer: A review
    • Pasqualini JR. The selective estrogen enzyme modulators in breast cancer: a review. Biochim Biophys Acta 2004; 1654: 123-43
    • (2004) Biochim Biophys Acta , vol.1654 , pp. 123-143
    • Pasqualini, J.R.1
  • 5
    • 0033047550 scopus 로고    scopus 로고
    • In vitro systems for the evaluation of the estrogenic activity of natural products
    • Diel P, Smolnikar K, Michna H. In vitro systems for the evaluation of the estrogenic activity of natural products. Planta Medica 1999; 65: 197-203
    • (1999) Planta Medica , vol.65 , pp. 197-203
    • Diel, P.1    Smolnikar, K.2    Michna, H.3
  • 6
    • 0141829776 scopus 로고    scopus 로고
    • Phytoestrogens: A review of the present state of research
    • Ososki AL, Kenelly EJ. Phytoestrogens: a review of the present state of research. Phytother Res 2003; 17: 845-69
    • (2003) Phytother Res , vol.17 , pp. 845-869
    • Ososki, A.L.1    Kenelly, E.J.2
  • 8
    • 0028959192 scopus 로고
    • Estrogenic flavonoids: Structural requirements for biological activity
    • Miksicek RJ. Estrogenic flavonoids: structural requirements for biological activity. Proc Soc Exp Biol Med 1995; 208: 44-50
    • (1995) Proc Soc Exp Biol Med , vol.208 , pp. 44-50
    • Miksicek, R.J.1
  • 12
    • 0036274089 scopus 로고    scopus 로고
    • Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)-naringenin and 8-prenylnaringenin
    • Zierau O, Gester S, Schwab P, Metz P, Kolba S, Wulf M, Vollmer G. Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)- naringenin and 8-prenylnaringenin. Planta Medica 2002; 68: 449-51
    • (2002) Planta Medica , vol.68 , pp. 449-451
    • Zierau, O.1    Gester, S.2    Schwab, P.3    Metz, P.4    Kolba, S.5    Wulf, M.6    Vollmer, G.7
  • 14
    • 0031444281 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
    • Gehm BD, McAndrews JM, Chien PY, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA 1997; 94: 14138-43
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14138-14143
    • Gehm, B.D.1    McAndrews, J.M.2    Chien, P.Y.3    Jameson, J.L.4
  • 16
    • 0037174158 scopus 로고    scopus 로고
    • Mammalian phytoestrogens: Enterodiol and enterolactone
    • Wang LQ. Mammalian phytoestrogens: enterodiol and enterolactone. J Chromatogr B 2002; 777: 289-309
    • (2002) J Chromatogr B , vol.777 , pp. 289-309
    • Wang, L.Q.1
  • 19
    • 0031589170 scopus 로고    scopus 로고
    • Daidzein sulfoconjugates are potent inhibitors of sterol sulfatase (EC 3.1.6.2)
    • Wong CK, Keung WM. Daidzein sulfoconjugates are potent inhibitors of sterol sulfatase (EC 3.1.6.2). Biochem Biophys Res Commun 1997; 233: 579-83
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 579-583
    • Wong, C.K.1    Keung, W.M.2
  • 21
    • 0031457707 scopus 로고    scopus 로고
    • Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids
    • Huang Z, Fasco MJ, Kaminsky LS. Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids. J Steroid Biochem Molec Biol 1997; 63: 9-15
    • (1997) J Steroid Biochem Molec Biol , vol.63 , pp. 9-15
    • Huang, Z.1    Fasco, M.J.2    Kaminsky, L.S.3
  • 22
    • 2342518791 scopus 로고    scopus 로고
    • The role of 17-beta-hydroxysteroid dehydrogenases
    • Mindich R, Möller G, Adamski J. The role of 17-beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 2004; 218: 7-20
    • (2004) Mol Cell Endocrinol , vol.218 , pp. 7-20
    • Mindich, R.1    Möller, G.2    Adamski, J.3
  • 23
    • 0033661942 scopus 로고    scopus 로고
    • 17-Beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma. A new development in intracrinology
    • Sasano H, Suzuki T, Takeyama J, Utsunomiya H, Ito K, Ariga N, Moriya T. 17-beta-hydroxysteroid dehydrogenase in human breast and endometrial carcinoma. A new development in intracrinology. Oncology 2000; 59: 5-12
    • (2000) Oncology , vol.59 , pp. 5-12
    • Sasano, H.1    Suzuki, T.2    Takeyama, J.3    Utsunomiya, H.4    Ito, K.5    Ariga, N.6    Moriya, T.7
  • 27
    • 0034712219 scopus 로고    scopus 로고
    • Effects of phytoestrogens on aromatase, 3β-hydroxysteroid dehydrogenase Δ5/Δ4 isomerase, 17β-hydroxysteroid dehydrogenase activities and human breast cancer cells
    • Le Bail JC, Champavier Y, Chulia A, Habrioux G. Effects of phytoestrogens on aromatase, 3β-hydroxysteroid dehydrogenase Δ5/Δ4 isomerase, 17β-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci 2000; 66: 1281-91
    • (2000) Life Sci , vol.66 , pp. 1281-1291
    • Le Bail, J.C.1    Champavier, Y.2    Chulia, A.3    Habrioux, G.4
  • 28
    • 0035808202 scopus 로고    scopus 로고
    • Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities
    • Le Bail JC, Pouget C, Fagnere C, Basly JP, Chulia AJ, Habrioux G. Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities. Life Sci 2001; 68: 751-61
    • (2001) Life Sci , vol.68 , pp. 751-761
    • Le Bail, J.C.1    Pouget, C.2    Fagnere, C.3    Basly, J.P.4    Chulia, A.J.5    Habrioux, G.6
  • 29
    • 0035690492 scopus 로고    scopus 로고
    • Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis
    • Vinh TK, Nicholls PJ, Kirby AJ, Simons C. Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis. J Enz Inhib 2001; 16: 417-24
    • (2001) J Enz Inhib , vol.16 , pp. 417-424
    • Vinh, T.K.1    Nicholls, P.J.2    Kirby, A.J.3    Simons, C.4
  • 30
    • 18744376170 scopus 로고    scopus 로고
    • note
    • Type 1 17β-HSD catalyses the conversion of androstenedione to testosterone but is mainly expressed in the testes and consequently is outside the scope of this review.
  • 31
    • 0035931322 scopus 로고    scopus 로고
    • Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5
    • Krazeisen A, Breitling R, Möller G, Adamski J. Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5. Mol Cell Endocrinol 2001; 171: 151-62
    • (2001) Mol Cell Endocrinol , vol.171 , pp. 151-162
    • Krazeisen, A.1    Breitling, R.2    Möller, G.3    Adamski, J.4
  • 32
    • 0035990916 scopus 로고    scopus 로고
    • Human 17beta-hydroxysteroid dehydrogenase type 5 is inhibited by dietary flavonoids
    • Krazeisen A, Breitling R, Möller G, Adamski J. Human 17beta-hydroxysteroid dehydrogenase type 5 is inhibited by dietary flavonoids. Adv Exp Med Biol 2002; 505: 151-61
    • (2002) Adv Exp Med Biol , vol.505 , pp. 151-161
    • Krazeisen, A.1    Breitling, R.2    Möller, G.3    Adamski, J.4
  • 33
    • 0032718655 scopus 로고    scopus 로고
    • Aromatase and intracrinology of estrogen in hormone-dependent tumors
    • Harada N. Aromatase and intracrinology of estrogen in hormone-dependent tumors. Oncology 1999; 57: 7-16
    • (1999) Oncology , vol.57 , pp. 7-16
    • Harada, N.1
  • 34
    • 0034016224 scopus 로고    scopus 로고
    • Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues
    • Chetrite GS, Corto-Prieto J, Philippe JC, Wright F. Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J Steroid Biochem Molec Biol 2000; 72: 23-7
    • (2000) J Steroid Biochem Molec Biol , vol.72 , pp. 23-27
    • Chetrite, G.S.1    Corto-Prieto, J.2    Philippe, J.C.3    Wright, F.4
  • 35
    • 0020073188 scopus 로고
    • Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
    • Akhtar M, Calder MR, Corina DL, Wright JN. Mechanistic studies on C-19 demethylation in oestrogen biosynthesis. Biochem J 1982; 201: 569-80
    • (1982) Biochem J , vol.201 , pp. 569-580
    • Akhtar, M.1    Calder, M.R.2    Corina, D.L.3    Wright, J.N.4
  • 36
    • 0021271612 scopus 로고
    • Inhibition of human estrogen synthetase (aromatase) by flavones
    • Kellis JT, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science 1984; 225: 1032-4
    • (1984) Science , vol.225 , pp. 1032-1034
    • Kellis, J.T.1    Vickery, L.E.2
  • 37
    • 0023794242 scopus 로고
    • Spectral perturbation of human microsomal cytochrome P-450 by flavonoid binding
    • Moochhala SM, Loke KH, Das NP. Spectral perturbation of human microsomal cytochrome P-450 by flavonoid binding. Biochem J 1988; 17: 755-62
    • (1988) Biochem J , vol.17 , pp. 755-762
    • Moochhala, S.M.1    Loke, K.H.2    Das, N.P.3
  • 41
    • 8444243681 scopus 로고    scopus 로고
    • Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells
    • Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci 2004; 82: 70-9
    • (2004) Toxicol Sci , vol.82 , pp. 70-79
    • Sanderson, J.T.1    Hordijk, J.2    Denison, M.S.3    Springsteel, M.F.4    Nantz, M.H.5    Van Den Berg, M.6
  • 42
    • 0031915796 scopus 로고    scopus 로고
    • Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study
    • Kao YC, Zhou CB, Sherman M, Laughton CA, Chen S. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Persp 1998; 106: 85-92
    • (1998) Environ Health Persp , vol.106 , pp. 85-92
    • Kao, Y.C.1    Zhou, C.B.2    Sherman, M.3    Laughton, C.A.4    Chen, S.5
  • 44
    • 0027365576 scopus 로고
    • Flavonoid inhibition of aromatase enzyme activity in human preadipocytes
    • Campbell DR, Kurzer MS. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Molec Biol 1993; 46: 381-88
    • (1993) J Steroid Biochem Molec Biol , vol.46 , pp. 381-388
    • Campbell, D.R.1    Kurzer, M.S.2
  • 45
    • 0036285967 scopus 로고    scopus 로고
    • Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats
    • Satoh K, Sakamoto Y, Ogata A, Nagai F, Mikuriya H, Numazawa M, Yamada K, Aoki N. Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. Food Chem Toxicol 2002; 40: 925-33
    • (2002) Food Chem Toxicol , vol.40 , pp. 925-933
    • Satoh, K.1    Sakamoto, Y.2    Ogata, A.3    Nagai, F.4    Mikuriya, H.5    Numazawa, M.6    Yamada, K.7    Aoki, N.8
  • 46
    • 0032994282 scopus 로고    scopus 로고
    • Screening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assay
    • White EL, Ross LJ, Steele VE, Kelloff GJ, Hill DL. Screening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assay. Anticancer Res 1999; 19: 1017-20
    • (1999) Anticancer Res , vol.19 , pp. 1017-1020
    • White, E.L.1    Ross, L.J.2    Steele, V.E.3    Kelloff, G.J.4    Hill, D.L.5
  • 51
    • 0036796816 scopus 로고    scopus 로고
    • Sulfonation and molecular action
    • Strott CA. Sulfonation and molecular action. Endocrin Rev 2002; 23: 703-732
    • (2002) Endocrin Rev , vol.23 , pp. 703-732
    • Strott, C.A.1
  • 52
    • 0033750995 scopus 로고    scopus 로고
    • Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells
    • Otake Y, Nolan AL, Walle K, Walle T. Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells. J Steroid Biochem Molec Biol 2000; 73: 265-70
    • (2000) J Steroid Biochem Molec Biol , vol.73 , pp. 265-270
    • Otake, Y.1    Nolan, A.L.2    Walle, K.3    Walle, T.4
  • 53
    • 0029916538 scopus 로고    scopus 로고
    • Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines
    • Falany JL, Falany CN. Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines. Cancer Res 1996; 56: 1551-5
    • (1996) Cancer Res , vol.56 , pp. 1551-1555
    • Falany, J.L.1    Falany, C.N.2
  • 55
    • 0030022005 scopus 로고    scopus 로고
    • Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention
    • Eaton EA, Walle UK, Lewis AJ, Hudson T, Wilson AA, Walle T. Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention. Drug Metab Dispos 1996; 24: 232-7
    • (1996) Drug Metab Dispos , vol.24 , pp. 232-237
    • Eaton, E.A.1    Walle, U.K.2    Lewis, A.J.3    Hudson, T.4    Wilson, A.A.5    Walle, T.6
  • 56
    • 0033543682 scopus 로고    scopus 로고
    • The effects of flavonoids on human phenolsulphotransferases: Potential in drug metabolism and chemoprevention
    • Ghazali RA, Waring RH. The effects of flavonoids on human phenolsulphotransferases: potential in drug metabolism and chemoprevention. Life Sci 1999; 65: 1625-32
    • (1999) Life Sci , vol.65 , pp. 1625-1632
    • Ghazali, R.A.1    Waring, R.H.2
  • 57
    • 0034950435 scopus 로고    scopus 로고
    • Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens?
    • Kirk CJ, Harris RM, Wood DM, Waring RH, Hughes PJ. Do dietary phytoestrogens influence susceptibility to hormone-dependent cancer by disrupting the metabolism of endogenous oestrogens? Biochem Soc Trans 2001; 29: 209-16
    • (2001) Biochem Soc Trans , vol.29 , pp. 209-216
    • Kirk, C.J.1    Harris, R.M.2    Wood, D.M.3    Waring, R.H.4    Hughes, P.J.5
  • 59
    • 0034083836 scopus 로고    scopus 로고
    • Oral absorption and bioavailability of tea catechins
    • Zhu M, Chen Y, Li RC. Oral absorption and bioavailability of tea catechins. Planta Medica 2000; 66: 444-7
    • (2000) Planta Medica , vol.66 , pp. 444-447
    • Zhu, M.1    Chen, Y.2    Li, R.C.3
  • 61
    • 1042290475 scopus 로고    scopus 로고
    • Cellular uptake and metabolism of flavonoids and their metabolites: Implication for their bioavailability
    • Spencer JPE, Abd El Mohsen M, Rice-Evans C. Cellular uptake and metabolism of flavonoids and their metabolites: implication for their bioavailability. Arch Biochem Biophys 2004; 423: 148-61
    • (2004) Arch Biochem Biophys , vol.423 , pp. 148-161
    • Spencer, J.P.E.1    Abd El Mohsen, M.2    Rice-Evans, C.3
  • 62
    • 18744390661 scopus 로고    scopus 로고
    • Compositions and methods of adjusting steroid hormone metabolism through facilitated absorption of hydrophobic dietary compounds. US Patent 6,086,915, 2000
    • Zeligs MA, Jacobs IC. Compositions and methods of adjusting steroid hormone metabolism through facilitated absorption of hydrophobic dietary compounds. US Patent 6,086,915, 2000.
    • Zeligs, M.A.1    Jacobs, I.C.2
  • 63
    • 0031011193 scopus 로고    scopus 로고
    • Exposure of infants to phyto-oestrogens from soy-based infant formula
    • Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 1997; 350: 23-7
    • (1997) Lancet , vol.350 , pp. 23-27
    • Setchell, K.D.1    Zimmer-Nechemias, L.2    Cai, J.3    Heubi, J.E.4
  • 64
    • 0035755189 scopus 로고    scopus 로고
    • Natural modulators of estrogen biosynthesis and function as chemopreventive agents
    • Bhat KPL, Pezzuto JM. Natural modulators of estrogen biosynthesis and function as chemopreventive agents. Arch Pharm Res 2001; 24: 73-84
    • (2001) Arch Pharm Res , vol.24 , pp. 73-84
    • Bhat, K.P.L.1    Pezzuto, J.M.2
  • 66
    • 0034684250 scopus 로고    scopus 로고
    • Natural products-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
    • Nicolaou KC, Pfefferkorn JA, Roecker AJ, Cao GQ, Barluenga S, Mitchell HJ. Natural products-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans. J Am Chem Soc 2000; 122: 9939-53
    • (2000) J Am Chem Soc , vol.122 , pp. 9939-9953
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Roecker, A.J.3    Cao, G.Q.4    Barluenga, S.5    Mitchell, H.J.6
  • 67
    • 18744374039 scopus 로고    scopus 로고
    • Compounds with a sulfamate group. WO 9732872, 1997
    • Reed JM, Potter BVL. Compounds with a sulfamate group. WO 9732872, 1997
    • Reed, J.M.1    Potter, B.V.L.2
  • 68
    • 18744405564 scopus 로고    scopus 로고
    • Preparation of flavone, isoflavone and flavanone sulfamates as estrone sulfatase and/or aromatase inhibitors for treatment of breast and endometrial cancers. US Patent 6,187,766, 2003
    • Reed JM, Potter BVL. Preparation of flavone, isoflavone and flavanone sulfamates as estrone sulfatase and/or aromatase inhibitors for treatment of breast and endometrial cancers. US Patent 6,187,766, 2003
    • Reed, J.M.1    Potter, B.V.L.2
  • 69
    • 18744405263 scopus 로고    scopus 로고
    • Preparation of novel benzofuranone derivatives as remedies for hormone-dependent diseases. WO 9830556, 1998
    • Yoshihama M, Nakakoshi M, Nakamura J, Nakayama S. Preparation of novel benzofuranone derivatives as remedies for hormone-dependent diseases. WO 9830556, 1998
    • Yoshihama, M.1    Nakakoshi, M.2    Nakamura, J.3    Nakayama, S.4
  • 70
    • 0035002051 scopus 로고    scopus 로고
    • Structure-based focusing using pharmacophores derived from the active site of 17β-hydroxysteroid dehydrogenase
    • Hoffren AM, Murray CM, Hoffmann RD. Structure-based focusing using pharmacophores derived from the active site of 17β-hydroxysteroid dehydrogenase. Curr Pharm Des 2001; 7: 547-66
    • (2001) Curr Pharm Des , vol.7 , pp. 547-566
    • Hoffren, A.M.1    Murray, C.M.2    Hoffmann, R.D.3
  • 71
    • 3042647052 scopus 로고    scopus 로고
    • Cinnamic acid esters as potent inhibitors of fungal 17β- hydroxysteroid dehydrogenase - A model enzyme of the short-chain dehydrogenase/reductase superfamily
    • Gobec S, Sova M, Kristan K, Rizner TL. Cinnamic acid esters as potent inhibitors of fungal 17β-hydroxysteroid dehydrogenase - a model enzyme of the short-chain dehydrogenase/reductase superfamily. Bioorg Med Chem Lett 2004; 14: 3933-6
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 3933-3936
    • Gobec, S.1    Sova, M.2    Kristan, K.3    Rizner, T.L.4
  • 72
    • 18744404129 scopus 로고    scopus 로고
    • Preparation of novel tetralone and benzopyranone derivatives as 17β-HSD inhibitors. WO 9832724, 1998
    • Yoshihama M, Nakakoshi M, Nakamura J, Nakayama S. Preparation of novel tetralone and benzopyranone derivatives as 17β-HSD inhibitors. WO 9832724, 1998
    • Yoshihama, M.1    Nakakoshi, M.2    Nakamura, J.3    Nakayama, S.4
  • 74
    • 0037152461 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition
    • Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ. Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. Bioorg Med Chem Lett. 2002; 12: 2859-61
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 2859-2861
    • Pouget, C.1    Fagnere, C.2    Basly, J.P.3    Habrioux, G.4    Chulia, A.J.5
  • 75
    • 0037041192 scopus 로고    scopus 로고
    • New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives
    • Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ. New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives. Bioorg Med Chem Lett 2002; 12: 1059-61
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 1059-1061
    • Pouget, C.1    Fagnere, C.2    Basly, J.P.3    Habrioux, G.4    Chulia, A.J.5
  • 76
    • 3242794236 scopus 로고    scopus 로고
    • Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones
    • Kim YW, Hackett JC, Brueggemeier RW. Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. J Med Chem 2004; 47: 4032-40
    • (2004) J Med Chem , vol.47 , pp. 4032-4040
    • Kim, Y.W.1    Hackett, J.C.2    Brueggemeier, R.W.3
  • 77
    • 0031830517 scopus 로고    scopus 로고
    • Prenylflavonoids: A new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship
    • Kitaoka M, Kadokawa H, Sugano M, Ichikawa K, Taki M, Takaishi S, Iijima Y, Tsutsumi S, Boriboon M, Akiyama T. Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship. Planta Medica 1998; 64: 511-5
    • (1998) Planta Medica , vol.64 , pp. 511-515
    • Kitaoka, M.1    Kadokawa, H.2    Sugano, M.3    Ichikawa, K.4    Taki, M.5    Takaishi, S.6    Iijima, Y.7    Tsutsumi, S.8    Boriboon, M.9    Akiyama, T.10
  • 78
    • 0031858870 scopus 로고    scopus 로고
    • Prenylflavonoids: A new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism
    • Miyamoto M, Matsushita Y, Kiyokawa A, Fukuda C, Iijima Y, Sugano M, Akiyama T. Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism. Planta Medica 1998; 64: 516-9
    • (1998) Planta Medica , vol.64 , pp. 516-519
    • Miyamoto, M.1    Matsushita, Y.2    Kiyokawa, A.3    Fukuda, C.4    Iijima, Y.5    Sugano, M.6    Akiyama, T.7
  • 79
    • 0021886262 scopus 로고
    • The endocrine effects of constituents of Cimicifuga racemosa. 2. In vitro binding of constituents to estrogen receptors
    • Jarry H, Harnischfeger G, Duker E. The endocrine effects of constituents of Cimicifuga racemosa. 2. In vitro binding of constituents to estrogen receptors. Planta Medica 1985; 51: 316-9
    • (1985) Planta Medica , vol.51 , pp. 316-319
    • Jarry, H.1    Harnischfeger, G.2    Duker, E.3
  • 80
    • 0033767071 scopus 로고    scopus 로고
    • Direct analysis and identification of triterpene glycosides by LC/MS in black cohosh, Cimicifuga racemosa, and in several commercially available black cohosh products
    • He K, Zheng B, Kim CH, Rogers L, Zheng Q. Direct analysis and identification of triterpene glycosides by LC/MS in black cohosh, Cimicifuga racemosa, and in several commercially available black cohosh products. Planta Medica 2000;66:635-40
    • (2000) Planta Medica , vol.66 , pp. 635-640
    • He, K.1    Zheng, B.2    Kim, C.H.3    Rogers, L.4    Zheng, Q.5
  • 83
    • 0036257506 scopus 로고    scopus 로고
    • Protodioscin (NSC-698 796): Its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel
    • Hu K, Yao X. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Medica 2002; 68: 297-301
    • (2002) Planta Medica , vol.68 , pp. 297-301
    • Hu, K.1    Yao, X.2
  • 84
    • 3843088349 scopus 로고    scopus 로고
    • Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry
    • Lu GH, Chan K, Chan CL, Leung K, Jiang ZH, Zhao ZZ. Quantification Of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometry. J Chromatogr A 2004; 1046: 101-7
    • (2004) J Chromatogr A , vol.1046 , pp. 101-107
    • Lu, G.H.1    Chan, K.2    Chan, C.L.3    Leung, K.4    Jiang, Z.H.5    Zhao, Z.Z.6
  • 85
    • 0028966126 scopus 로고
    • Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens
    • Makela S, Poutanen M, Lehtimaeki J, Kostian ML, Santti R, Vihko R. Estrogen-specific 17 beta-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens. Proc Soc Exp Biol Med 1995; 208: 51-9
    • (1995) Proc Soc Exp Biol Med , vol.208 , pp. 51-59
    • Makela, S.1    Poutanen, M.2    Lehtimaeki, J.3    Kostian, M.L.4    Santti, R.5    Vihko, R.6
  • 86
    • 0034753762 scopus 로고    scopus 로고
    • Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement
    • Coldham NG, Sauer MJ. Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement. Food Chem Toxicol 2001; 39: 1211-24
    • (2001) Food Chem Toxicol , vol.39 , pp. 1211-1224
    • Coldham, N.G.1    Sauer, M.J.2
  • 87
  • 89
    • 18744410544 scopus 로고    scopus 로고
    • Inhibiting aromatase with specific dietary supplements. US Patent 2004156926, 2004
    • Anderson ML. Inhibiting aromatase with specific dietary supplements. US Patent 2004156926, 2004
    • Anderson, M.L.1


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