Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2859-2861

  Pouget, Christelle ^a   Fagnere, Catherine ^a   Basly, Jean Philippe ^a   Habrioux, G ^a   Chulia, A J ^a  

^a UNIVERSITÉ DE LIMOGES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 IMIDAZOLYL 7 METHOXYFLAVAN; 7 HYDROXY 4 IMIDAZOLYLFLAVAN; AMINOGLUTETHIMIDE; AROMATASE; CARBON; FLAVAN DERIVATIVE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

AROMATASE; AROMATASE INHIBITORS; DRUG DESIGN; ENZYME INHIBITORS; FEMALE; FLAVONOIDS; HUMANS; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; PLACENTA; PREGNANCY; PROTONS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037152461     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00565-6     Document Type: Article

References (9)

1. Brodie A.M.H., Njar V.C.O. Steroids. 65:2000;171.
2. Goss P.E., Strasser K. J. Clin. Oncol. 19:2001;881.
3. Kellis J.T., Vickery L.E. Science. 225:1984;1032.
4. Ibrahim A.R., Abul-Hajj Y.J. J. Steroid Biochem. Mol. Biol. 37:1990;257.
5. Le Bail J.C., Laroche T., Marre-Fournier F., Habrioux G. Cancer Lett. 133:1998;101.
6. Jeong H.J., Shin Y.G., Kim I.H., Pezzuto J.M. Arch. Pharm. Res. 22:1999;309.
7. Pouget C., Fagnere C., Basly J.P., Leveque H., Chulia A.J. Tetrahedron. 56:2000;6047.
8. Clark-Lewis J.W. Aust. J. Chem. 21:1968;2059.
9. Bolger B.J., Hirwe A., Marathe K.G., Philbin E.M., Vickars M.A. Tetrahedron. 22:1966;621.