Muscle assembly: A titanic achievement?

Current Opinion in Cell Biology

Volumn 11, Issue 1, 1999, Pages 18-25

  Gregorio, Carol C ^a   Granzier, Henk ^b   Sorimachi, Hiroyuki ^c   Labeit, Siegfried ^d  

^a UNIVERSITY OF ARIZONA   (United States)

^b Pharmacology and Physiology   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIN; MUSCLE PROTEIN; NEBULIN;

CHEMICAL STRUCTURE; EUKARYOTIC CELL; MUSCLE; MUSCLE FIBRIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SARCOMERE; SKELETAL MUSCLE;

EUKARYOTA;

EID: 0033004087     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(99)80003-9     Document Type: Article

References (54)

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21. ••].
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24. •].
25. •].
26. •]. Therefore, this part of I-band titin is predicted to interact with actin.
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39. ••].
40. ••].
41. ••] are pioneering studies in which single titin molecules were manipulated and titin's force-extension properties were characterized at the molecular level. The results obtained reveal that titin behaves as an entropic spring. Unfolding takes place at high force during stretching of the molecule, and refolding at low force during release of the molecule.
42. ••].
43. ••] use novel epitope-mapped antibodies to monitor the mechanical behavior of central I-band titin during myofibrillar stretch. They prove that the PEVK (in the single letter code for amino acids) region of titin acts as a highly extensible spring element which is responsible for the passive tension response of the titin filament.
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