-
1
-
-
0003685242
-
-
B. Hames, & D. Glover. New York: Oxford University Press
-
Krainer A. Hames B., Glover D. Eukaryotic mRNA Processing. 1997;Oxford University Press, New York.
-
(1997)
Eukaryotic mRNA Processing
-
-
Krainer, A.1
-
2
-
-
0033812002
-
Heterocyclic modifications of oligonucleotides and antisense technology
-
Herdewijn P. Heterocyclic modifications of oligonucleotides and antisense technology. Antisense Nucleic Acid Drug Dev. 10:2000;297-310.
-
(2000)
Antisense Nucleic Acid Drug Dev
, vol.10
, pp. 297-310
-
-
Herdewijn, P.1
-
3
-
-
0034951870
-
Backbone modification of nucleic acids: Synthesis, structure and therapeutic applications
-
Micklefield J. Backbone modification of nucleic acids: synthesis, structure and therapeutic applications. Curr Med Chem. 8:2001;1157-1179.
-
(2001)
Curr Med Chem
, vol.8
, pp. 1157-1179
-
-
Micklefield, J.1
-
4
-
-
0035502474
-
Modification of alternative splicing pathways as a potential chemotherapy for cancer and other diseases
-
Mercatante D., Sazani P., Kole R. Modification of alternative splicing pathways as a potential chemotherapy for cancer and other diseases. Curr Cancer Drug Targets. 1:2001;211-230.
-
(2001)
Curr Cancer Drug Targets
, vol.1
, pp. 211-230
-
-
Mercatante, D.1
Sazani, P.2
Kole, R.3
-
5
-
-
0032750621
-
2′-Carbohydrate modifications in antisense oligonucleotide therapy: Importance of conformation, configuration and conjugation
-
Manoharan M. 2′-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochim Biophys Acta. 1489:1999;117-130.
-
(1999)
Biochim Biophys Acta
, vol.1489
, pp. 117-130
-
-
Manoharan, M.1
-
6
-
-
0034945672
-
Antisense effects in the cell nucleus: Modification of splicing
-
Kole R., Sazani P. Antisense effects in the cell nucleus: modification of splicing. Curr Opin Mol Ther. 3:2001;229-234.
-
(2001)
Curr Opin Mol Ther
, vol.3
, pp. 229-234
-
-
Kole, R.1
Sazani, P.2
-
7
-
-
0032700356
-
Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides
-
Agrawal S. Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochim Biophys Acta. 1489:1999;53-68.
-
(1999)
Biochim Biophys Acta
, vol.1489
, pp. 53-68
-
-
Agrawal, S.1
-
8
-
-
0034744290
-
2′-O,4′-C-Methylene bridged nucleic acid (2′,4′-BNA): Synthesis and triplex-forming properties
-
Obika S., Uneda T., Sugimoto T., Nanbu D., Minami T., Doi T., Imanishi T. 2′-O,4′-C-Methylene bridged nucleic acid (2′,4′-BNA): synthesis and triplex-forming properties. Bioorg Med Chem. 9:2001;1001-1011.
-
(2001)
Bioorg Med Chem
, vol.9
, pp. 1001-1011
-
-
Obika, S.1
Uneda, T.2
Sugimoto, T.3
Nanbu, D.4
Minami, T.5
Doi, T.6
Imanishi, T.7
-
9
-
-
0035951767
-
2′-O,4′-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH. Thermodynamic and kinetic studies
-
Torigoe H., Hari Y., Sekiguchi M., Obika S., Imanishi T. 2′-O,4′-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH. Thermodynamic and kinetic studies. J Biol Chem. 276:2001;2354-2360.
-
(2001)
J Biol Chem
, vol.276
, pp. 2354-2360
-
-
Torigoe, H.1
Hari, Y.2
Sekiguchi, M.3
Obika, S.4
Imanishi, T.5
-
10
-
-
0037033135
-
2′-O,4′-C-ethylene-bridged nucleic acids (ENA): Highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug
-
Morita K., Hasegawa C., Kaneko M., Tsutsumi S., Sone J., Ishikawa T., Imanishi T., Koizumi M. 2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug. Bioorg Med Chem Lett. 12:2002;73-76.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 73-76
-
-
Morita, K.1
Hasegawa, C.2
Kaneko, M.3
Tsutsumi, S.4
Sone, J.5
Ishikawa, T.6
Imanishi, T.7
Koizumi, M.8
-
11
-
-
0033544603
-
Oligonucleotide N3′→P5′ phosphoramidates as potential therapeutic agents
-
Gryaznov S.M. Oligonucleotide N3′→P5′ phosphoramidates as potential therapeutic agents. Biochim Biophys Acta. 1489:1999;131-140.
-
(1999)
Biochim Biophys Acta
, vol.1489
, pp. 131-140
-
-
Gryaznov, S.M.1
-
12
-
-
0032699477
-
Morpholino antisense oligomers: The case for an RNase H-independent structural type
-
Summerton J. Morpholino antisense oligomers: the case for an RNase H-independent structural type. Biochim Biophys Acta. 1489:1999;141-158.
-
(1999)
Biochim Biophys Acta
, vol.1489
, pp. 141-158
-
-
Summerton, J.1
-
13
-
-
0035048016
-
Application of PNA and LNA oligomers to chemotherapy
-
Elayadi A.N., Corey D.R. Application of PNA and LNA oligomers to chemotherapy. Curr Opin Investig Drugs. 2:2001;558-561.
-
(2001)
Curr Opin Investig Drugs
, vol.2
, pp. 558-561
-
-
Elayadi, A.N.1
Corey, D.R.2
-
14
-
-
0037065662
-
Crystal structure of double helical hexitol nucleic acids
-
Declercq R., Van Aerschot A., Read R.J., Herdewijn P., Van Meervelt L. Crystal structure of double helical hexitol nucleic acids. J Am Chem Soc. 124:2002;928-933.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 928-933
-
-
Declercq, R.1
Van Aerschot, A.2
Read, R.J.3
Herdewijn, P.4
Van Meervelt, L.5
-
15
-
-
0034945672
-
Antisense effects in the cell nucleus: Modification of splicing
-
Kole R., Sazani P. Antisense effects in the cell nucleus: modification of splicing. Curr Opin Mol Ther. 3:2001;229-234.
-
(2001)
Curr Opin Mol Ther
, vol.3
, pp. 229-234
-
-
Kole, R.1
Sazani, P.2
-
16
-
-
0004270772
-
-
R. Hoffman, E. Benz, S. Shattil, B. Furie, H. Cohen, L. Silberstein, & P. McGlave. New York: Churchill Livingston
-
Schwartz E., Benz E. Hoffman R., Benz E., Shattil S., Furie B., Cohen H., Silberstein L., McGlave P. Thalassemia Syndromes. 1995;Churchill Livingston, New York.
-
(1995)
Thalassemia Syndromes
-
-
Schwartz, E.1
Benz, E.2
-
17
-
-
0034662881
-
Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients
-
Morpholino antisense oligonucleotides corrected aberrant splicing of β-globin pre-mRNA in hematopoietic progenitor cells from thalassemic patients and increased production of functional hemoglobin.
-
Lacerra G., Sierakowska H., Carestia C., Fucharoen S., Summerton J., Weller D., Kole R. Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients. Proc Natl Acad Sci USA. 97:2000;9591-9596. Morpholino antisense oligonucleotides corrected aberrant splicing of β-globin pre-mRNA in hematopoietic progenitor cells from thalassemic patients and increased production of functional hemoglobin.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9591-9596
-
-
Lacerra, G.1
Sierakowska, H.2
Carestia, C.3
Fucharoen, S.4
Summerton, J.5
Weller, D.6
Kole, R.7
-
18
-
-
0035844238
-
Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. Analysis of apoptosis and cell death
-
Antisense oligonucleotides that shift splicing of bcl-x pre-mRNA from the anti- to the pro-apoptotic splice variant induced apoptosis in a prostate cancer cell line.
-
Mercatante D.R., Bortner C.D., Cidlowski J.A., Kole R. Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. Analysis of apoptosis and cell death. J Biol Chem. 276:2001;16411-16417. Antisense oligonucleotides that shift splicing of bcl-x pre-mRNA from the anti- to the pro-apoptotic splice variant induced apoptosis in a prostate cancer cell line.
-
(2001)
J Biol Chem
, vol.276
, pp. 16411-16417
-
-
Mercatante, D.R.1
Bortner, C.D.2
Cidlowski, J.A.3
Kole, R.4
-
19
-
-
0035900725
-
Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17
-
Kalbfuss B., Mabon S.A., Misteli T. Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17. J Biol Chem. 276:2001;42986-42993.
-
(2001)
J Biol Chem
, vol.276
, pp. 42986-42993
-
-
Kalbfuss, B.1
Mabon, S.A.2
Misteli, T.3
-
20
-
-
0035976992
-
Modulation of survival motor neuron pre-mRNA splicing by inhibition of alternative 3′ splice site pairing
-
Lim S.R., Hertel K.J. Modulation of survival motor neuron pre-mRNA splicing by inhibition of alternative 3′ splice site pairing. J Biol Chem. 276:2001;45476-45483.
-
(2001)
J Biol Chem
, vol.276
, pp. 45476-45483
-
-
Lim, S.R.1
Hertel, K.J.2
-
21
-
-
0035477551
-
Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs
-
Sazani P., Kang S.H., Maier M.A., Wei C., Dillman J., Summerton J., Manoharan M., Kole R. Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs. Nucleic Acids Res. 29:2001;3965-3974.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 3965-3974
-
-
Sazani, P.1
Kang, S.H.2
Maier, M.A.3
Wei, C.4
Dillman, J.5
Summerton, J.6
Manoharan, M.7
Kole, R.8
-
22
-
-
0034746953
-
Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo
-
Faria M., Spiller D.G., Dubertret C., Nelson J.S., White M.R., Scherman D., Helene C., Giovannangeli C. Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo. Nat Biotechnol. 19:2001;40-44.
-
(2001)
Nat Biotechnol
, vol.19
, pp. 40-44
-
-
Faria, M.1
Spiller, D.G.2
Dubertret, C.3
Nelson, J.S.4
White, M.R.5
Scherman, D.6
Helene, C.7
Giovannangeli, C.8
-
23
-
-
0037086052
-
Morpholino oligos: Making sense of antisense?
-
Heasman J. Morpholino oligos: making sense of antisense? Dev Biol. 243:2002;209-214.
-
(2002)
Dev Biol
, vol.243
, pp. 209-214
-
-
Heasman, J.1
-
24
-
-
0035829517
-
Gridlock signalling pathway fashions the first embryonic artery
-
Zhong T.P., Childs S., Leu J.P., Fishman M.C. Gridlock signalling pathway fashions the first embryonic artery. Nature. 414:2001;216-220.
-
(2001)
Nature
, vol.414
, pp. 216-220
-
-
Zhong, T.P.1
Childs, S.2
Leu, J.P.3
Fishman, M.C.4
-
25
-
-
0036548741
-
Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms
-
Wang H., Wang S., Nan L., Yu D., Agrawal S., Zhang R. Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: in vivo activity and mechanisms. Int J Oncol. 20:2002;745-752.
-
(2002)
Int J Oncol
, vol.20
, pp. 745-752
-
-
Wang, H.1
Wang, S.2
Nan, L.3
Yu, D.4
Agrawal, S.5
Zhang, R.6
-
26
-
-
85031347329
-
-
Isis Pharmaceuticals on World Wide Web URL: http://www.isispharmaceuticals.com/pipeline.htm .
-
-
-
-
27
-
-
0035807863
-
Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2′-O-methyl/LNA oligoribonucleotides
-
Arzumanov A., Walsh A.P., Rajwanshi V.K., Kumar R., Wengel J., Gait M.J. Inhibition of HIV-1 Tat-dependent trans activation by steric block chimeric 2′-O-methyl/LNA oligoribonucleotides. Biochemistry. 40:2001;14645-14654.
-
(2001)
Biochemistry
, vol.40
, pp. 14645-14654
-
-
Arzumanov, A.1
Walsh, A.P.2
Rajwanshi, V.K.3
Kumar, R.4
Wengel, J.5
Gait, M.J.6
-
28
-
-
0034680771
-
Restoration of correct splicing of thalassemic beta-globin pre-mRNA by modified U1 snRNAs
-
Gorman L., Mercatante D.R., Kole R. Restoration of correct splicing of thalassemic beta-globin pre-mRNA by modified U1 snRNAs. J Biol Chem. 275:2000;35914-35919.
-
(2000)
J Biol Chem
, vol.275
, pp. 35914-35919
-
-
Gorman, L.1
Mercatante, D.R.2
Kole, R.3
-
29
-
-
0036137663
-
Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing
-
Reprogramming splicing of pre-mRNA by spliceosome-mediated RNA trans-splicing corrected endogenous mutant CFTR pre-mRNA in cystic fibrosis airway epithelia and partially restored CFTR-mediated chloride transport.
-
Liu X., Jiang Q., Mansfield S.G., Puttaraju M., Zhang Y., Zhou W., Cohn J.A., Garcia-Blanco M.A., Mitchell L.G., Engelhardt J.F. Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nat Biotechnol. 20:2002;47-52. Reprogramming splicing of pre-mRNA by spliceosome-mediated RNA trans-splicing corrected endogenous mutant CFTR pre-mRNA in cystic fibrosis airway epithelia and partially restored CFTR-mediated chloride transport.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 47-52
-
-
Liu, X.1
Jiang, Q.2
Mansfield, S.G.3
Puttaraju, M.4
Zhang, Y.5
Zhou, W.6
Cohn, J.A.7
Garcia-Blanco, M.A.8
Mitchell, L.G.9
Engelhardt, J.F.10
-
30
-
-
0036365052
-
In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
-
Abounader R., Lal B., Luddy C., Koe G., Davidson B., Rosen E.M., Laterra J. In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J. 16:2002;108-110.
-
(2002)
FASEB J
, vol.16
, pp. 108-110
-
-
Abounader, R.1
Lal, B.2
Luddy, C.3
Koe, G.4
Davidson, B.5
Rosen, E.M.6
Laterra, J.7
-
31
-
-
0035214161
-
Effect of deletion and the site of insertion in double copy anti-tat retroviral vectors: Viral titres and production of anti-tat mRNA
-
Carr J.M., Calvert J.K., Kumar R., Burrel C.J., Li P. Effect of deletion and the site of insertion in double copy anti-tat retroviral vectors: viral titres and production of anti-tat mRNA. Arch Virol. 146:2001;2191-2200.
-
(2001)
Arch Virol
, vol.146
, pp. 2191-2200
-
-
Carr, J.M.1
Calvert, J.K.2
Kumar, R.3
Burrel, C.J.4
Li, P.5
-
32
-
-
85047698397
-
Inhibition of HIV-1 replication by novel lentiviral vectors expressing transdominant Rev and HIV-1 env antisense
-
Mautino M.R., Morgan R.A. Inhibition of HIV-1 replication by novel lentiviral vectors expressing transdominant Rev and HIV-1 env antisense. Gene Ther. 9:2002;421-431.
-
(2002)
Gene Ther
, vol.9
, pp. 421-431
-
-
Mautino, M.R.1
Morgan, R.A.2
-
33
-
-
0035698533
-
Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury
-
Fahmy R.G., Khachigian L.M. Antisense Egr-1 RNA driven by the CMV promoter is an inhibitor of vascular smooth muscle cell proliferation and regrowth after injury. J Cell Biochem. 84:2002;575-582.
-
(2002)
J Cell Biochem
, vol.84
, pp. 575-582
-
-
Fahmy, R.G.1
Khachigian, L.M.2
-
34
-
-
0035918465
-
In vivo control of NMDA receptor transcript level in motoneurons by viral transduction of a short antisense gene
-
Finegold A.A., Perez F.M., Iadarola M.J. In vivo control of NMDA receptor transcript level in motoneurons by viral transduction of a short antisense gene. Brain Res Mol Brain Res. 90:2001;17-25.
-
(2001)
Brain Res Mol Brain Res
, vol.90
, pp. 17-25
-
-
Finegold, A.A.1
Perez, F.M.2
Iadarola, M.J.3
-
35
-
-
0035834012
-
Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs
-
Quan S., Yang L., Abraham N.G., Kappas A. Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs. Proc Natl Acad Sci USA. 98:2001;12203-12208.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12203-12208
-
-
Quan, S.1
Yang, L.2
Abraham, N.G.3
Kappas, A.4
-
36
-
-
0035195965
-
Inhibition of carcinoma cell growth and metastasis by a vesicular stomatitis virus G-pseudotyped retrovector expressing type I insulin-like growth factor receptor antisense
-
Samani A.A., Fallavollita L., Jaalouk D.E., Galipeau J., Brodt P. Inhibition of carcinoma cell growth and metastasis by a vesicular stomatitis virus G-pseudotyped retrovector expressing type I insulin-like growth factor receptor antisense. Hum Gene Ther. 12:2001;1969-1977.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1969-1977
-
-
Samani, A.A.1
Fallavollita, L.2
Jaalouk, D.E.3
Galipeau, J.4
Brodt, P.5
-
37
-
-
0035090127
-
The future of hypertension therapy: Sense, antisense, or nonsense?
-
Pachori A.S., Huentelman M.J., Francis S.C., Gelband C.H., Katovich M.J., Raizada M.K. The future of hypertension therapy: sense, antisense, or nonsense? Hypertension. 37:2001;357-364.
-
(2001)
Hypertension
, vol.37
, pp. 357-364
-
-
Pachori, A.S.1
Huentelman, M.J.2
Francis, S.C.3
Gelband, C.H.4
Katovich, M.J.5
Raizada, M.K.6
-
38
-
-
0036110088
-
Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy
-
This study demonstrates that a single intracardiac administration of a retroviral vector containing angiotensin II type I receptor antisense in the neonatal rat resulted in long-term expression of the antisense transgene in various cardiovascular tissues, causing a significant attenuation of cardiac hypertrophy.
-
Pachori A.S., Numan M.T., Ferrario C.M., Diz D.M., Raizada M.K., Katovich M.J. Blood pressure-independent attenuation of cardiac hypertrophy by AT(1)R-AS gene therapy. Hypertension. 39:2002;969-975. This study demonstrates that a single intracardiac administration of a retroviral vector containing angiotensin II type I receptor antisense in the neonatal rat resulted in long-term expression of the antisense transgene in various cardiovascular tissues, causing a significant attenuation of cardiac hypertrophy.
-
(2002)
Hypertension
, vol.39
, pp. 969-975
-
-
Pachori, A.S.1
Numan, M.T.2
Ferrario, C.M.3
Diz, D.M.4
Raizada, M.K.5
Katovich, M.J.6
-
39
-
-
0003305490
-
High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA
-
in press
-
Vacek MM, Ma H, Gemignani F, Lacerra G, Kafri T, Kole R: High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA. Blood 2002, in press.
-
(2002)
Blood
-
-
Vacek, M.M.1
Ma, H.2
Gemignani, F.3
Lacerra, G.4
Kafri, T.5
Kole, R.6
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